Association between glucose metabolism disorder and prevalence of thyroid nodule in the elderly in iodine-adequate area

Wang Xiaowei; He Dian; Zhang Mengjie; Ni Wenjing; Sun Yu; Fan Kuanlu; Liu Chao; Xu Shuhang

doi:10.13406/j.cnki.cyxb.003127

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Association between glucose metabolism disorder and prevalence of thyroid nodule in the elderly in iodine-adequate area

Thyroiddiseasein the elderly | 更新时间：2025-10-21

- Association between glucose metabolism disorder and prevalence of thyroid nodule in the elderly in iodine-adequate area
- Journal of Chongqing Medical University Vol. 47, Issue 11, Pages: 1300-1304(2022)
- 作者机构：
  
  1.南京中医药大学附属中西医结合医院内分泌科，南京 210028
  2.扬州大学建湖临床医学院内分泌科，盐城 224700
  3.徐州医科大学附属宿迁医院内分泌科，宿迁 223800
  4.徐州医科大学第二附属医院内分泌科，徐州 221006
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003127
  CLC： R581
- Received：21 June 2022，
  
  Published：28 November 2022
- 稿件说明：
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王晓玮,何殿,张梦杰,等.适碘地区老年人群糖代谢紊乱与甲状腺结节患病率的相关性[J].重庆医科大学学报,2022,47(11):1300-1304.

Wang Xiaowei,He Dian,Zhang Mengjie,et al.Association between glucose metabolism disorder and prevalence of thyroid nodule in the elderly in iodine-adequate area[J].Journal of Chongqing Medical University,2022,47(11):1300-1304.
王晓玮,何殿,张梦杰,等.适碘地区老年人群糖代谢紊乱与甲状腺结节患病率的相关性[J].重庆医科大学学报,2022,47(11):1300-1304. DOI： 10.13406/j.cnki.cyxb.003127.

Wang Xiaowei,He Dian,Zhang Mengjie,et al.Association between glucose metabolism disorder and prevalence of thyroid nodule in the elderly in iodine-adequate area[J].Journal of Chongqing Medical University,2022,47(11):1300-1304. DOI： 10.13406/j.cnki.cyxb.003127.

摘要

目的

调查适碘地区老年人群甲状腺结节的患病率，探讨老年人群糖代谢指标与甲状腺结节的相关性。

方法

选取江苏省宿迁市和徐州市共2 037例老年人（男1 045例，51.3%）进行体格检查、生化检测及甲状腺超声检查。采用logistic回归分析糖代谢指标与甲状腺结节患病、结节个数、结节大小、结节良性和可疑恶性之间的关系。

结果

适碘老年人群甲状腺结节的患病率为35.1%，其中42.4%为多发结节，33.9%的结节≥1 cm。有甲状腺结节组与无甲状腺结节组、单个结节组和多个结节组以及结节

1 cm组和结节≥1 cm组相比，性别、腰围、空腹胰岛素、胰岛素抵抗指数水平差异有统计学意义（均

0.05）。logistic回归模型校正混杂因素后，空腹血糖、糖化血红蛋白、胰岛素抵抗指数与甲状腺结节患病、甲状腺结节大小相关。

结论

适碘地区老年人甲状腺结节的患病率较高。糖代谢紊乱与甲状腺结节患病、结节大小密切相关。

Abstract

Objective

To investigate the prevalence of thyroid nodules in the elderly in iodine-adequate area， and to explore the correlation between glucose metabolism disorders and thyroid nodules in the elderly.

Methods

A total of 2 037 elderly people（1 045 males， 51.3%） were enrolled from Suqian and Xuzhou in Jiangsu Province. All the participants underwent physical examination，biochemical test，and thyroid ultrasonography. Logistic regression was used to analyze the relationship between glucose metabolism and thyroid nodule prevalence，thyroid nodule number，thyroid nodule size，benign thyroid nodules and suspected malignant nodules.

Results

The prevalence of thyroid nodules in the elderly in iodine-adequate area was 35.1%，of which 42.4% were multiple nodules and 33.9% were nodules ≥1 cm. There were significant differences in sex，waist circumference，fasting insulin level and insulin resistance index between the groups with and without thyroid nodules，single thyroid nodule group and multiple thyroid nodule group and nodule

1 cm group and nodule ≥1 cm group（all

0.05）. After the confounding factors were adjusted by the logistic regression model，results showed that fasting blood glucose，glycosylated hemoglobin and insulin resistance index were associated with the risk of thyroid nodule occurrence and the size of thyroid nodules.

Conclusion

Thyroid nodules is prevalent in the elderly in iodine-adequate area. Glucose metabolism disorder is significantly related to the prevalence and size of thyroid nodules.

关键词

Keywords

references

Haugen BR ， Alexander EK ， Bible KC ， et al . 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer：the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer [J ] . Thyroid ， 2016 ， 26 （ 1 ）： 1 - 133 .

Guth S ， Theune U ， Aberle J ， et al . Very high prevalence of thyroid nodules detected by high frequency（13 MHz） ultrasound examination [J ] . Eur J Clin Invest ， 2009 ， 39 （ 8 ）： 699 - 706 .

中华医学会糖尿病学分会 . 中国2型糖尿病防治指南（2020年版） [J ] . 国际内分泌代谢杂志， 2021 ， 41 （ 5 ）： 482 - 548 .

Diabetes Society of Chinese Medical Association . Guideline for the prevention and treatment of type 2 diabetes mellitus in China（2020 edition） [J ] . Int J Endocrinol Metab ， 2021 ， 41 （ 5 ）： 482 - 548 .

Sinclair A ， Saeedi P ， Kaundal A ， et al . Diabetes and global ageing among 65-99-year-old adults：findings from the International Diabetes Federation Diabetes Atlas，9 th edition [J ] . Diabetes Res Clin Pract ， 2020 ， 162 ： 108078 .

Li YZ ， Teng D ， Shi XG ， et al . Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association：national cross sectional study [J ] . BMJ ， 2020 ， 369 ： m997 .

Anil C ， Akkurt A ， Ayturk S ， et al . Impaired glucose metabolism is a risk factor for increased thyroid volume and nodule prevalence in a mild-to-moderate iodine deficient area [J ] . Metabolism ， 2013 ， 62 （ 7 ）： 970 - 975 .

Tessler FN ， Middleton WD ， Grant EG ， et al . Re：ACR thyroid imaging，reporting and data system （TI-RADS）：white paper of the ACR TI-RADS committee [J ] . J Am Coll Radiol ， 2018 ， 15 （ 3 Pt A ）： 381 - 382 .

Ayturk S ， Gursoy A ， Kut A ， et al . Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area [J ] . Eur J Endocrinol ， 2009 ， 161 （ 4 ）： 599 - 605 .

Rezzonico J ， Rezzonico M ， Pusiol E ， et al . Introducing the thyroid gland as another victim of the insulin resistance syndrome [J ] . Thyroid ， 2008 ， 18 （ 4 ）： 461 - 464 .

Zhang HM ， Feng QW ， Niu YX ， et al . Thyroid nodules in type 2 diabetes mellitus [J ] . Curr Med Sci ， 2019 ， 39 （ 4 ）： 576 - 581 .

Feng SY ， Zhang ZW ， Xu SH ， et al . The prevalence of thyroid nodules and their association with metabolic syndrome risk factors in a moderate iodine intake area [J ] . Metab Syndr Relat Disord ， 2017 ， 15 （ 2 ）： 93 - 97 .

Wang K ， Yang Y ， Wu Y ， et al . The association between insulin resistance and vascularization of thyroid nodules [J ] . J Clin Endocrinol Metab ， 2015 ， 100 （ 1 ）： 184 - 192 .

Ospina NS ， Papaleontiou M . Thyroid nodule evaluation and management in older adults：a review of practical considerations for clinical endocrinologists [J ] . Endocr Pract ， 2021 ， 27 （ 3 ）： 261 - 268 .

Aschebrook-Kilfoy B ， Sabra MM ， Brenner A ， et al . Diabetes and thyroid cancer risk in the national institutes of health-AARP diet and health study [J ] . Thyroid ， 2011 ， 21 （ 9 ）： 957 - 963 .

曾　幸，刘慧霞，萧梅芳，等 . 甲状腺癌在2型糖尿病患者中患病情况及相关因素分析 [J ] . 中国普通外科杂志， 2019 ， 28 （ 5 ）： 558 - 564 .

Zeng X ， Liu HX ， Xiao MF ， et al . Analysis of prevalence of thyroid cancer in patients with type 2 diabetes mellitus and the relevant factors [J ] . Chin J Gen Surg ， 2019 ， 28 （ 5 ）： 558 - 564 .

Luo JH ， Phillips L ， Liu SM ， et al . Diabetes，diabetes treatment，and risk of thyroid cancer [J ] . J Clin Endocrinol Metab ， 2016 ， 101 （ 3 ）： 1243 - 1248 .

Guo SD . Insulin signaling，resistance，and the metabolic syndrome：insights from mouse models into disease mechanisms [J ] . J Endocrinol ， 2014 ， 220 （ 2 ）： T1 - T23 .

Dumont JE ， Lamy F ， Roger P ， et al . Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors [J ] . Physiol Rev ， 1992 ， 72 （ 3 ）： 667 - 697 .

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