Correlation between the ascending aortic elasticity evaluated by speckle tracking imaging and the coronary artery lesion of patients with coronary heart disease

Chen Yue; Liu Rong; Zhou Jun; Zhou Chang; Dong Zhizhi; Liu Zulin; Shi Douzi

doi:10.13406/j.cnki.cyxb.003047

您当前的位置：

首页 >

文章列表页 >

Correlation between the ascending aortic elasticity evaluated by speckle tracking imaging and the coronary artery lesion of patients with coronary heart disease

Clinical study | 更新时间：2025-10-21

- Correlation between the ascending aortic elasticity evaluated by speckle tracking imaging and the coronary artery lesion of patients with coronary heart disease
- Journal of Chongqing Medical University Vol. 48, Issue 2, Pages: 210-214(2023)
- 作者机构：
  
  三峡大学第一临床医学院宜昌市中心人民医院超声科，宜昌 443000
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003047
  CLC： R541.4
- Received：22 September 2021，
  
  Revised：2022-05-05，
  
  Accepted：23 May 2022，
  
  Published：28 February 2023
- 稿件说明：
移动端阅览
陈悦,刘蓉,周军,等.斑点追踪技术评估升主动脉弹性与冠心病患者冠脉病变的相关性研究[J].重庆医科大学学报,2023,48(2):210-214.

Chen Yue,Liu Rong,Zhou Jun,et al.Correlation between the ascending aortic elasticity evaluated by speckle tracking imaging and the coronary artery lesion of patients with coronary heart disease[J].Journal of Chongqing Medical University,2023,48(2):210-214.
陈悦,刘蓉,周军,等.斑点追踪技术评估升主动脉弹性与冠心病患者冠脉病变的相关性研究[J].重庆医科大学学报,2023,48(2):210-214. DOI： 10.13406/j.cnki.cyxb.003047.

Chen Yue,Liu Rong,Zhou Jun,et al.Correlation between the ascending aortic elasticity evaluated by speckle tracking imaging and the coronary artery lesion of patients with coronary heart disease[J].Journal of Chongqing Medical University,2023,48(2):210-214. DOI： 10.13406/j.cnki.cyxb.003047.

摘要

目的

使用二维斑点追踪技术（two-dimensional speckle tracking imaging，2D-STI）评估冠心病患者升主动脉弹性功能，并探讨其与冠脉病变程度的相关性。

方法

纳入三峡大学第一临床医学院宜昌市中心人民医院2020年1月至2021年3月因胸闷、胸痛住院的疑似冠心病患者206例。均行超声心动图检查，计算升主动脉扩张性（aortic distensibility，AoDIS）、升主动脉僵硬指数（aortic stiffness index，AoSI）及升主动脉应变值等常规动脉僵硬度指标。使用2D-STI测量整体周向升主动脉应变峰值（global circumferential acscending aortic peak strain，GCAAS）及周向升主动脉峰值应变率（crcumferential acscending aortic peak strain rate，CAASR）。依据冠脉造影结果及Gensini积分（Gensini score，GS）分为冠心病组（轻度组、中度组及重度组）和对照组。

结果

①冠心病组AoDIS、升主动脉应变值、GCAAS、CAASR均低于对照组，AoSI高于对照组（均

0.05）。②单因素logistic回归分析显示，男性、糖尿病、高血压、左室射血分数（left ventricular ejection fraction，LVEF）、AoDIS、GCAAS、CAASR均是冠心病的危险因素（均

0.05）。经多因素分析后，GCAAS仍是冠心病的独立危险因素（

0.001）。③冠心病组中，GCAAS及CAASR随着冠脉病变严重程度增加而减少（

0.003，

0.015）。与轻度组相比，重度组GCAAS、CAASR明显更低（

0.001，

0.012）。Spearman相关分析表明，GCAAS与GS呈中度相关（

=-0.411，

0.001），CAASR与GS呈弱相关（

=-0.228，

0.027）。

结论

斑点追踪技术升主动脉应变优于常规超声，能够反映冠心病患者升主动脉弹性的早期改变，整体周向升主动脉应变与冠心病的发生及冠脉病变严重程度密切相关。

Abstract

Objective

To evaluate the elastic function of ascending aortic in patients with coronary heart disease（CHD） by two-dimensional speckle tracking imaging（2D-STI），and to explore its correlation with the degree of coronary artery lesion.

Methods

A total of 206 patients with suspected CHD who were admitted to our hospital due to chest tiredness or chest pain from January 2020 to March 2021 were enrolled in the study. All subjects underwent echocardiography，and routine arterial stiffness indexes such as the ascending aortic distensibility（AoDIS），ascending aortic stiffness index（AoSI） and ascending aortic strain values were calculated. Then 2D-STI was used to measure the global circumferential ascending aortic peak strain（GCAAS） and circumferential ascending aortic peak strain rate（CAASR）. According to the results of coronary angiography and Gensini score（GS），they were divided into CAD group（mild group，moderate group and severe group） and control group.

Results

①AoDIS，ascending aortic strain value，GCAAS and CAASR in the CHD group were lower than those in the control group，and AoSI in the CHD group was higher than that in the control group（all

0.05）. ②Univariate logistic regression analysis showed that man，diabetes，hypertension，left ventricular ejection fraction （LVEF），AoDIS，GCAAS and CAASR were all risk factors for CHD（all

0.05）. After multivariate analysis，GCAAS was still a risk factor for CHD（

0.001）. ③In the CHD group，GCAAS and CAASR decreased as the severity of coronary artery lesion increased（

0.003，

0.015）. GCAAS and CAASR in the severe group were significantly lower than those in the mild group（

=0.001，

=0.012）. Spearman correlation analysis showed that GCAAS was moderately correlated with GS（

=-0.411，

0.001），while CAASR was weakly correlated with GS（

=-0.228，

=0.027）.

Conclusion

The ascending aortic strain of 2D-STI is superior to conventional ultrasound technology in reflecting the early changes in the elasticity of the ascending aortic in patients with CHD. The global circumferential ascending aortic strain is closely related to the occurrence and progression of CHD and the severity of coronary artery lesion.

关键词

Keywords

references

World Health Organization . Cardiovascular diseases (CVDs) [EB/OL ] . ( 2017-05-17 ) [ 2021-08-01 ] . http://www.who.int/mediacentre/factsheets/fs317/en/ http://www.who.int/mediacentre/factsheets/fs317/en/ .

Duprez DA . Arterial stiffness and endothelial function：key players in vascular health [J ] . Hypertension ， 2010 ， 55 （ 3 ）： 612 - 613 .

Bonarjee VVS . Arterial stiffness：a prognostic marker in coronary heart disease. Available methods and clinical application [J ] . Front Cardiovasc Med ， 2018 ， 5 ： 64 .

Ahmadi N ， Nabavi V ， Hajsadeghi F ， et al . Impaired aortic distensibility measured by computed tomography is associated with the severity of coronary artery disease [J ] . Int J Cardiovasc Imaging ， 2011 ， 27 （ 3 ）： 459 - 469 .

Oishi Y ， Mizuguchi Y ， Miyoshi H ， et al . A novel approach to assess aortic stiffness related to changes in aging using a two-dimensional strain imaging [J ] . Echocardiography ， 2008 ， 25 （ 9 ）： 941 - 945 .

Recommendations for cardiac chamber quantification by echocardiography in adults：an update from the American society of echocardiography and the European association of，cardiovascular imaging [J ] . Eur Heart J Cardiovasc Imaging ， 2016 ， 17 （ 4 ）： 412 .

Santarpia G ， Scognamiglio G ， di Salvo G ， et al . Aortic and left ventricular remodeling in patients with bicuspid aortic valve without significant valvular dysfunction：a prospective study [J ] . Int J Cardiol ， 2012 ， 158 （ 3 ）： 347 - 352 .

Nistri S ， Grande-Allen J ， Noale M ， et al . Aortic elasticity and size in bicuspid aortic valve syndrome [J ] . Eur Heart J ， 2007 ， 29 （ 4 ）： 472 - 479 .

Rampidis GP ， Benetos G ， Benz DC ， et al . A Guide for Gensini Score calculation [J ] . Atherosclerosis ， 2019 ， 287 ： 181 - 183 .

Cheng KS ， Baker CR ， Hamilton G ， et al . Arterial elastic properties and cardiovascular risk/event [J ] . Eur J Vasc Endovascular Surg ， 2002 ， 24 （ 5 ）： 383 - 397 .

Sethi S ， Rivera O ， Oliveros R ， et al . Aortic stiffness：pathophysiology，clinical implications，and approach to treatment [J ] . Integr Blood Press Control ， 2014 ， 7 ： 29 - 34 .

Hiebert JB ， Vacek J ， Shah Z ， et al . Use of speckle tracking to assess heart failure with preserved ejection fraction [J ] . J Cardiol ， 2019 ， 74 （ 5 ）： 397 - 402 .

Longobardo L ， Carerj S ， Bitto A ， et al . Bicuspid aortic valve and aortopathy：novel prognostic predictors for the identification of high-risk patients [J ] . Eur Heart J Cardiovasc Imaging ， 2020 ， 22 （ 7 ）： 808 - 816 .

Stefanadis C ， Wooley CF ， Bush CA ， et al . Aortic distensibility abnormalities in coronary artery disease [J ] . Am J Cardiol ， 1987 ， 59 （ 15 ）： 1300 - 1304 .

Chirinos JA ， Segers P ， Hughes T ， et al . Large-artery stiffness in health and disease [J ] . J Am Coll Cardiol ， 2019 ， 74 （ 9 ）： 1237 - 1263 .

Bu ZH ， Ma J ， Fan YB ， et al . Ascending aortic strain analysis using 2-dimensional speckle tracking echocardiography improves the diagnostics for coronary artery stenosis in patients with suspected stable angina pectoris [J ] . J Am Heart Assoc ， 2018 ， 7 （ 14 ）： e008802 .

Waheed N ， Elias-Smale S ， Malas W ， et al . Sex differences in non-obstructive coronary artery disease [J ] . Cardiovasc Res ， 2020 ， 116 （ 4 ）： 829 - 840 .

Ferrannini G ， Manca ML ， Magnoni M ， et al . Coronary artery disease and type 2 diabetes：a proteomic study [J ] . Dia Care ， 2021 ， 44 （ 4 ）： 1071 .

Kringeland E ， Tell GS ， Midtbø H ， et al . Stage 1 hypertension，sex，and acute coronary syndromes during midlife：the Hordaland Health Study [J ] . Eur J Prev Cardiol ， 2022 ， 29 （ 1 ）： 147 - 154 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Correlation of soluble growth stimulation expressed gene 2 and galectin-3 with myocardial fibrosis in patients with coronary artery disease

Correlation between coronary heart disease and intestinal flora

Association of ADAMTS1 gene single nucleotide polymorphisms with coronary heart disease in Chinese Han population

Relationship between serum uric acid level and coronary heart disease

Effects of percutaneous transluminal coronary angioplasty on p wave dispersion

Related Author

Deng Wei

Zhang Yulian

Zheng Fang

Chen Shiyu

Wang Yunhui

Jin Xingfang

Fang Lang

Xie Lingzhi

Related Institution

Department of General Medicine，The Second Affiliated Hospital of Chongqing Medical University

Department of Geriatrics，The Affiliated Yan’an Hospital of Kunming Medical University

Department of Clinical Research Center,The First Affiliated Hospital of Chongqing Medical University

重庆医科大学临床学院心内科

Department of Cardiology,College of Clinical Medicine,Chongqing Medical University

⁰