Predictive value of serum HDAC1 and PSGL-1 for pulmonary infection after thoracoscopic radical resection of lung cancer

DING Jia-bao; ZHANG Qian; WANG Zi-xiao; LIANG Hua-gang

doi:10.11659/jjssx.12E025098

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Predictive value of serum HDAC1 and PSGL-1 for pulmonary infection after thoracoscopic radical resection of lung cancer

Clinical Research | 更新时间：2026-07-24

- Predictive value of serum HDAC1 and PSGL-1 for pulmonary infection after thoracoscopic radical resection of lung cancer
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 35, Issue 7, Pages: 619-624(2026)
- 作者机构：
  
  1.秦皇岛市第一医院胸外科，河北秦皇岛 066000
  2.秦皇岛市第一医院风湿免疫科，河北秦皇岛 066000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.12E025098
  CLC： R734.2;R619.3
- Received：18 December 2025，
  
  Online First：24 July 2026，
  
  Published：25 July 2026
- 稿件说明：
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丁家宝,张倩,王梓骁等.血清HDAC1、PSGL-1对胸腔镜肺癌根治术后肺部感染的预测价值[J].局解手术学杂志,2026,35(07):619-624.

DING Jia-bao,ZHANG Qian,WANG Zi-xiao,et al.Predictive value of serum HDAC1 and PSGL-1 for pulmonary infection after thoracoscopic radical resection of lung cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(07):619-624.
丁家宝,张倩,王梓骁等.血清HDAC1、PSGL-1对胸腔镜肺癌根治术后肺部感染的预测价值[J].局解手术学杂志,2026,35(07):619-624. DOI： 10.11659/jjssx.12E025098.

DING Jia-bao,ZHANG Qian,WANG Zi-xiao,et al.Predictive value of serum HDAC1 and PSGL-1 for pulmonary infection after thoracoscopic radical resection of lung cancer[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(07):619-624. DOI： 10.11659/jjssx.12E025098.

摘要

目的

探究血清组蛋白去乙酰化酶1（HDAC1）、P-选择素糖蛋白配体1（PSGL-1）对胸腔镜肺癌根治术后肺部感染的预测价值。

方法

选取2023年6月至2025年6月于我院接受胸腔镜肺癌根治术治疗的100例患者为研究对象，根据术后72 h内肺部感染情况分为感染组（

=20）和未感染组（

=80）。检测引起肺部感染的病原菌；酶联免疫吸附法检测2组患者术前及术后6 h血清HDAC1、PSGL-1水平，并分析术后肺部感染的影响因素。受试者工作特征（

ROC

）曲线和决策曲线分析（

DCA

）评估血清HDAC1、PSGL-1水平对术后肺部感染的预测价值。

结果

20例感染患者共检测出33株病原菌，以革兰阴性菌为主。感染组患者术后血清HDAC1、PSGL-1水平显著高于未感染组（

0.05）。感染组患者合并肺部基础疾病、病理分期为ⅢA期、术前第1秒用力呼气量占预计值的百分比

80%、联合肺叶切除、术后入ICU占比及C反应蛋白、可溶性髓系细胞触发受体-1、高迁移率族蛋白B1水平高于未感染组（

0.05）。多因素

Logistic

回归分析结果显示，血清HDAC1和PSGL-1水平升高是肺癌患者术后肺部感染的独立危险因素（

0.05）。

ROC

曲线分析结果显示，HDAC1、PSGL-1联合预测肺癌患者术后肺部感染的曲线下面积（

AUC

）达0.908（95%

CI：

0.835~0.980）；

DCA

结果显示，HDAC1和PSGL-1水平联合预测模型在高风险阈值为0.20~0.88时净获益率高于单独预测。

结论

胸腔镜肺癌根治术后肺部感染患者血清HDAC1、PSGL-1水平升高，术后早期检测二者水平能够辅助预测肺部感染发生。

Abstract

Objective

To explore the predictive value of serum histone deacetylase 1 （HDAC1） and P-selectin glycoprotein ligand 1 （PSGL-1） for pulmonary infection after thoracoscopic radical resection of lung cancer.

Methods

A total of 100 patients who underwent thoracoscopic radical resection of lung cancer at our hospital from June 2023 to June 2025 were selected as the study subjects. They were divided into the infected group （

=20） and the uninfected group （

=80） according to the occurrence of pulmonary infection within 72 hours after surgery. The pathogenic bacteria causing pulmonary infection were detected. Enzyme-linked immunosorbent assay was used to detect serum HDAC1 and PSGL-1 levels of patients in the two groups before surgery and 6 hours after surgery. The influencing factors of postoperative pulmonary infection were analyzed.

Receiver operating characteristic

（

ROC

） curve and

decision curve analysis

（

DCA

） were used to evaluate the predictive value of serum HDAC1 and PSGL-1 levels for postoperative pulmonary infection.

Results

A total of 33 strains of pathogenic bacteria were detected in 20 infected patients， with Gram-negative bacteria being the predominant organisms. The postoperative serum HDAC1 and PSGL-1 levels in the infected group were significantly higher than those in the uninfected group （

0.05）. The infected group showed significantly higher proportions of patients with underlying pulmonary diseases， pathological stage ⅢA， preoperative percentage of predicted forced expiratory volume in the first second

80%， combined lobectomy， postoperative ICU admission， and higher levels of C-reactive protein， soluble triggering receptor expressed on myeloid cells-1， and high mobility group box 1 protein than the uninfected group （

0.05）. The results of multivariate

Logistic

regression analysis showed that elevated levels of serum HDAC

1 and PSGL-1 were independent risk factors for postoperative pulmonary infection in lung cancer patients （

0.05）. The

ROC

curve results showed that

area under the curve

（

AUC

） of HDAC1 and PSGL-1 combined prediction for postoperative pulmonary infection in lung cancer patients reached 0.908 （95%

： 0.835 to 0.980）.

DCA

demonstrated that the combined prediction model of HDAC1 and PSGL‑1 yielded superior net benefit compared with single prediction within the high‑risk threshold range of 0.20 to 0.88.

Conclusion

Serum HDAC1 and PSGL-1 levels are elevated in patients with pulmonary infection after thoracoscopic radical resection of lung cancer. Early detection of these levels after surgery can assist in predicting the occurrence of pulmonary infection.

关键词

Keywords

references

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