Application of ultrasound-guided methylene blue dye localization in high-risk non-palpable breast nodules

SHI Dai-wei; PENG Kun; SANG Sai-long; YAO Bao-zhong; LI Hong-lin; CHEN Hong-cun

doi:10.11659/jjssx.12E025012

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Application of ultrasound-guided methylene blue dye localization in high-risk non-palpable breast nodules

Precise Diagnosis and Treatment of Breast and Thyroid Diseases | 更新时间：2026-07-31

- Application of ultrasound-guided methylene blue dye localization in high-risk non-palpable breast nodules
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 35, Issue 8, Pages: 670-673(2026)
- 作者机构：
  
  合肥市第二人民医院甲乳外科，安徽合肥 230000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.12E025012
  CLC： R655.8
- Received：02 December 2025，
  
  Online First：31 July 2026，
  
  Published：25 August 2026
- 稿件说明：
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石代伟,彭琨,桑赛龙等.超声引导下亚甲蓝定位染色在触诊阴性乳腺高危结节中的应用[J].局解手术学杂志,2026,35(08):670-673.

SHI Dai-wei,PENG Kun,SANG Sai-long,et al.Application of ultrasound-guided methylene blue dye localization in high-risk non-palpable breast nodules[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(08):670-673.
石代伟,彭琨,桑赛龙等.超声引导下亚甲蓝定位染色在触诊阴性乳腺高危结节中的应用[J].局解手术学杂志,2026,35(08):670-673. DOI： 10.11659/jjssx.12E025012.

SHI Dai-wei,PENG Kun,SANG Sai-long,et al.Application of ultrasound-guided methylene blue dye localization in high-risk non-palpable breast nodules[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(08):670-673. DOI： 10.11659/jjssx.12E025012.

摘要

目的

研究超声平面内法引导下亚甲蓝定位染色在触诊阴性乳腺高危结节活检中的应用。

方法

回顾性分析2023年6月至2024年6月我院收治的42例触诊阴性乳腺高危结节（BI-RADS 4b类及以上）患者资料。采用超声平面内法引导下亚甲蓝定位染色对触诊阴性乳腺高危结节进行定位，并行活检手术。统计术中病理和术后病理结果。记录患者术后染色剂相关的副反应及术后并发症情况。观察患者皮肤表面染剂残留情况。评估患者术后切口愈合情况及局部病灶的残留、复发情况。

结果

42例患者共有45个触诊阴性高危结节病灶，均顺利完成活检。术后均取得明确的病理诊断。恶性病变患者均在我科行进一步手术治疗，病理证实术中切除病灶包膜均完整，扩大标本无肿瘤残留。术后随访发现良性病变患者均无局部病灶的残留及复发，切口愈合良好，乳腺外观较术前无明显改变。

结论

超声平面内法引导下亚甲蓝定位染色技术在触诊阴性的乳腺高危结节活检中，具有定位准确、可视化强、活检成功率高的特点，且价格低廉，有重要临床应用价值。

Abstract

Objective

To explore the application of ultrasound-guided methylene blue dye localization in the biopsy of high-risk non-palpable breast nodules.

Methods

The data of 42 patients with high-risk non-palpable breast nodules （BI-RADS category 4b or above） admitted to our hospital from June 2023 to June 2024 was retrospectively analyzed. The location of high-risk non-palpable breast nodules was determined by methylene blue site-specific staining guided by the intravitreal ultrasound method， and biopsy surgery was performed. The intraoperative and postoperative pathological results were statistically analyzed. The side effects related to staining agents and postoperative complications of the patients after the operation were recorded.The residue of dye on the patient's skin surface was observed.The postoperative incision healing condition， the residual of local lesions and recurrence of the patients were evaluated.

Results

Among the 42 patients， there were a total of 45 high-risk non-palpable nodular lesions，and biopsy was successfully completed for all of them. All patients received clear pathological diagnosis after the operation. Patients with malignant lesions underwent further surgical treatment in our department. Pathology confirmed that the lesion capsules removed during the operation were all intact， and there was no tumor residue in the enlarged specimens.Postoperative follow-up revealed that patients with benign lesions had no residual or recurrent local lesions，the incisions healed well，and there was no significant change in the appearance of the breast compared with that before the operation.

Conclusion

The application of ultrasound-guided methylene blue dye localization technique in the biopsy of high-risk non-palpable breast nodules has the characteristics of accurate localization， strong visualization， high biopsy success rate， and low cost， which has important clinical application value.

关键词

Keywords

references

雷少元，郑荣寿，张思维，等 . 乳腺癌发病率和死亡率的全球模式：一项基于人群的2000—2020年肿瘤登记数据分析研究［J］. 癌症， 2022 ， 41 （ 7 ）： 324 - 335 . doi： 10.3321/j.issn.1000-467X.2022.7.ez202207003 http://dx.doi.org/10.3321/j.issn.1000-467X.2022.7.ez202207003 .

王凤，马子堂 . 不可触及乳腺癌的乳腺X射线摄影表现及其临床病理特征分析［J］. 影像研究与医学应用， 2023 ， 7 （ 11 ）： 103 - 105 . doi： 10.3969/j.issn.2096-3807.2023.11.034 http://dx.doi.org/10.3969/j.issn.2096-3807.2023.11.034 .

甘家兵，姜丽琴，余丽娜 . 超声置针定位与麦默通手术在临床触诊阴性但超声可见乳腺结节中的应用与分析［J］. 中国当代医药， 2025 ， 32 （ 5 ）： 84 - 87 . doi： 10.3969/j.issn.1674-4721.2025.05.18 http://dx.doi.org/10.3969/j.issn.1674-4721.2025.05.18 .

王茂盛，袁育韬，王本忠 . 不可触及乳腺病变的临床分析［J］. 安徽医专学报， 2022 ， 4 ： 111 - 112 . doi： 10.3969/j.issn.2097-0196（2022）04-0111-03 http://dx.doi.org/10.3969/j.issn.2097-0196（2022）04-0111-03 .

朱涛，徐杰，田甜 . 超声引导下不同标记法对不可触及乳腺肿物病灶切除准确率及切除组织量的影响［J］. 分子诊断与治疗杂志， 2023 ， 15 （ 12 ）： 2083 - 2087 . doi： 10.3969/j.issn.1674-6929. 2023.12.012 http://dx.doi.org/10.3969/j.issn.1674-6929.2023.12.012 .

付强，王志强，王凤 . 超声引导下导丝定位在不可触及乳腺病灶切除中的应用意义［J］. 中国医疗器械信息， 2023 ， 29 （ 20 ）： 52 - 54 . doi ： 10.3969/j.issn.1006-6586.2023.20.017 http://dx.doi.org/10.3969/j.issn.1006-6586.2023.20.017 .

周瑞，吴高松，侯晋轩 . 乳腺X线三维立体定位真空辅助乳腺活检在乳腺X线可疑钙化诊断中的价值［J］. 中国微创外科杂志， 2022 ， 22 （ 9 ）： 700 - 704 . doi： 10.3969/j.issn.1009-6604.2022. 09.003 http://dx.doi.org/10.3969/j.issn.1009-6604.2022.09.003 .

李晓博，吴志粉，陈阵仁 . ICG荧光示踪法联合亚甲蓝染色在乳腺癌患者前哨淋巴结活检中的应用价值［J］. 实用癌症杂志， 2024 ， 39 （ 12 ）： 2064 - 2067 . doi： 10.3969/j.issn.1001-5930.2024.12.034 http://dx.doi.org/10.3969/j.issn.1001-5930.2024.12.034 .

Czarnecki DJ ， Feider HK ， Splittgerber GF . Toluidine blue dye as a breast localizationmarker ［J］. AJR Am J Roentgenol ， 1989 ， 153 （ 2 ）： 261 - 263 . doi： 10.2214/ajr.153.2.261 http://dx.doi.org/10.2214/ajr.153.2.261 .

李开富，康骅 . 乳腺癌外科治疗的历史演变［J］. 中国医刊， 2024 ， 59 （ 5 ）： 465 - 471 . doi： 10.3969/j.issn.1008-1070.2024. 05.001 http://dx.doi.org/10.3969/j.issn.1008-1070.2024.05.001 .

Luo WQ ， Huang QX ， Huang XW ， et al . Predicting breast cancer in breast imaging reporting and data system （BI-RADS） Ultrasound category 4 or 5 lesions： a nomogram combining radiomics and BI-RADS ［J］. Sci Rep ， 2019 ， 9 （ 1 ）： 11921 . doi： 10.1038/s41598-019-48488-4 http://dx.doi.org/10.1038/s41598-019-48488-4 .

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