Correlation between serum ferritin and response rate and prognosis of lung cancer immunotherapy

JIANG Li; HUANG Xiao; FU Yu; LU Xing; LIAO Su-ying; JIANG Jian

doi:10.11659/jjssx.12E024080

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Correlation between serum ferritin and response rate and prognosis of lung cancer immunotherapy

Clinical Research | 更新时间：2025-07-31

- Correlation between serum ferritin and response rate and prognosis of lung cancer immunotherapy
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 8, Pages: 711-714(2025)
- 作者机构：
  
  陆军军医大学第一附属医院检验科，重庆 400038
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.12E024080
  CLC： R734.2
- Received：13 December 2024，
  
  Published：25 August 2025
- 稿件说明：
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蒋梨,黄晓,傅余等.血清铁蛋白与肺癌免疫治疗反应率及预后的相关性研究[J].局解手术学杂志,2025,34(08):711-714.

JIANG Li,HUANG Xiao,FU Yu,et al.Correlation between serum ferritin and response rate and prognosis of lung cancer immunotherapy[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(08):711-714.
蒋梨,黄晓,傅余等.血清铁蛋白与肺癌免疫治疗反应率及预后的相关性研究[J].局解手术学杂志,2025,34(08):711-714. DOI： 10.11659/jjssx.12E024080.

JIANG Li,HUANG Xiao,FU Yu,et al.Correlation between serum ferritin and response rate and prognosis of lung cancer immunotherapy[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(08):711-714. DOI： 10.11659/jjssx.12E024080.

摘要

目的

研究肺癌患者血清铁蛋白水平与病理分型、肿瘤分期、PD-L1表达、疾病控制率（DCR）和生存期的相关性。

方法

选取我院2020年2月至2021年2月收治的85例肺癌患者为研究对象。所有患者均接受免疫治疗，检测患者免疫治疗前后的血清铁蛋白水平。同时根据免疫治疗前后血清铁蛋白水平差值将患者分为升高组（31例）和降低组（54例）。分析患者血清铁蛋白水平与病理分型、肿瘤分期和PD-L1表达水平的相关性，同时比较治疗前血清铁蛋白水平≥300 ng/mL和

300 ng/mL患者以及升高组和降低组患者的DCR和生存期。

Kaplan

Meier

方法分析各组患者的生存曲线。

结果

肿瘤分期Ⅰ~Ⅲ期患者的血清铁蛋白水平明显低于Ⅳ期患者(

0.05)。血清铁蛋白水平≥300 ng/mL的患者DCR、3年生存率和无进展生存期（PFS）均明显低/短于血清铁蛋白水平

300 ng/mL的患者(

0.05)；升高组患者的DCR、3年生存率和PFS均明显低/短于降低组(

0.05)。

结论

肺癌患者治疗前血清铁蛋白水平升高及治疗后水平进一步升高与免疫治疗效果降低、生存期缩短显著相关，结合治疗前血清铁蛋白基线水平与治疗后动态变化，有望作为预测免疫治疗效果的临床标志物组合。

Abstract

Objective

To study the correlation between the serum ferritin level and the pathological classification， tumor stage，PD-L1 expression， disease control rate （DCR）， and survival period of patients with lung cancer.

Methods

A total of 85 patients with lung cancer

admitted to our hospital from February 2020 to February 2021 were selected as the research subjects. All patients received immunotherapy， and the serum ferritin levels of patients before and after immunotherapy were detected. Meanwhile， according to the difference in serum ferritin levels before and after immunotherapy， the patients were divided into the increased group （31 cases） and the decreased group （54 cases）. The correlation between the serum ferritin level and the pathological classification， tumor stage and PD-L1 expression level of patients was analyzed， and the DCRs and survival periods of patients with serum ferritin level ≥300 ng/mL and

300 ng/mL before treatment were compared， as well as the increased group and the decreased group. The survival curve of patients in each group was analyzed by the

Kaplan

Meier

Results

Patients with tumor stage Ⅰ to Ⅲ showed significantly lower serum ferritin levels than patients with tumor stage Ⅳ （

0.05）.The DCR，3-year survival rate and progression-free survival （PFS） of patients with serum ferritin level ≥300 ng/mL were significantly lower/shorter than those of patients with serum ferritin level

300 ng/mL （

0.05）. The DCR， 3-year survival rate and PFS of patients in the increased group were significantly lower/shorter than those in the decreased group （

0.05）.

Conclusion

The increased serum ferritin level in lung cancer patients before treatment and the further increase after treatment are significantly associated with the reduced efficacy of immunotherapy and the shortened survival period. The combination of baseline serum ferritin levels before treatment and dynamic changes after treatment may serve as a clinical biomarker panel for predicting immunotherapy outcomes.

关键词

Keywords

references

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