Analysis of influencing factors of diabetes insipidus after pituitary tumor surgery

HE Mao-lin; ZHOU Chang-long

doi:10.11659/jjssx.11E024061

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Analysis of influencing factors of diabetes insipidus after pituitary tumor surgery

Clinical Research | 更新时间：2025-05-26

- Analysis of influencing factors of diabetes insipidus after pituitary tumor surgery
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 5, Pages: 405-407(2025)
- 作者机构：
  
  重庆医科大学附属永川医院神经外科，重庆 402160
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.11E024061
  CLC： R651.1+3
- Received：13 November 2024，
  
  Published：25 May 2025
- 稿件说明：
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何茂林,周昌龙.垂体瘤术后发生尿崩症的影响因素分析[J].局解手术学杂志,2025,34(05):405-407.

HE Mao-lin,ZHOU Chang-long.Analysis of influencing factors of diabetes insipidus after pituitary tumor surgery[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(05):405-407.
何茂林,周昌龙.垂体瘤术后发生尿崩症的影响因素分析[J].局解手术学杂志,2025,34(05):405-407. DOI： 10.11659/jjssx.11E024061.

HE Mao-lin,ZHOU Chang-long.Analysis of influencing factors of diabetes insipidus after pituitary tumor surgery[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(05):405-407. DOI： 10.11659/jjssx.11E024061.

摘要

目的

分析垂体瘤术后尿崩症的影响因素，为加强垂体瘤术后管理和预防垂体瘤术后尿崩症提供参考依据。

方法

回顾性分析我院2014年1月至2024年10月行垂体瘤手术的患者临床资料，通过单因素分析探讨各变量与术后发生尿崩症的关系，采用多因素回归分析识别术后发生尿崩症的独立危险因素。

结果

单因素分析显示，垂体瘤术后尿崩症的发生与肿瘤侵袭性、肿瘤生长方向、手术切除程度、手术时间及手术方式等相关（

0.05）。

Logistic

回归分析显示，手术时间

4 h（

=0.001）及肿瘤突破鞍膈生长（

=0.004）均是患者术后并发尿崩症的独立危险因素。

结论

手术时间及肿瘤生长方向与垂体瘤术后并发尿崩症密切相关，术前应充分做好评估，明确肿瘤生长方向；术中尽可能采取微创术式，提高手术医生技能以缩短手术时间；术后密切观察，以降低垂体瘤术后尿崩症的发生率。

Abstract

Objective

To analyze the influencing factors of diabetes insipidus after pituitary tumor surgery，thereby providing evidence for enhancing perioperative management of pituitary tumor surgery and preventing diabetes insipidus after pituitary tumor surgery.

Methods

The clinical data of patients who underwent pituitary tumor surgery in our hospital from January 2014 to December 2024 were retrospectively analyzed. The relationship between each variable and postoperative diabetes insipidus was explored through univariate analysis，and multivariate regression analysis was used to identify the independent risk factors for the occurrence of postoperative diabetes insipidus.

Results

Univariate analysis showed that the occurrence of diabetes insipidus after pituitary tumor surgery was related to tumor invasiveness，tumor growth direction，surgical resection degree，surgical time and surgical method （

0.05）.

Logistic

regression analysis showed that the surgical time

4 hours （

=0.001） and tumor growth breaking through diaphragma sellae （

=0.004） were independent risk factors for the occurrence of postoperative diabetes insipidus.

Conclusion

The surgical time and tumor growth direction are closely related to diabetes insipidus after pituitary tumor surgery； therefore，in order to reduce the incidence of diabetes insipidus after pituitary tumor surgery，a thorough evaluation should be conducted preoperatively to clarify the direction of tumor growth；minimally invasive surgery should be adopted as much as possible during the operation and the skills of surgeons should be improved to shorten the surgical time；and close observation should performed after surgery.

关键词

Keywords

references

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