Clinical efficacy and safety analysis of microsurgery combined with fluorescence navigation in the treatment of skull base meningiomas

DONG Hai-jun; GUO Jun-xia; LIANG Sheng

doi:10.11659/jjssx.10E025109

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Clinical efficacy and safety analysis of microsurgery combined with fluorescence navigation in the treatment of skull base meningiomas

Clinical Research | 更新时间：2026-06-16

- Clinical efficacy and safety analysis of microsurgery combined with fluorescence navigation in the treatment of skull base meningiomas
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 35, Issue 6, Pages: 528-533(2026)
- 作者机构：
  
  1.邯郸市中西医结合医院神经外科，河北邯郸 056000
  2.邯郸市第一医院血液内科，河北邯郸 056002
  3.沧州市中心医院药房，河北沧州 061012
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.10E025109
  CLC： R739.45;R739.41
- Received：30 October 2025，
  
  Published：25 June 2026
- 稿件说明：
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董海军,郭俊霞,梁盛.显微手术联合荧光导航治疗颅底脑膜瘤的临床疗效及安全性分析[J].局解手术学杂志,2026,35(06):528-533.

DONG Hai-jun,GUO Jun-xia,LIANG Sheng.Clinical efficacy and safety analysis of microsurgery combined with fluorescence navigation in the treatment of skull base meningiomas[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(06):528-533.
董海军,郭俊霞,梁盛.显微手术联合荧光导航治疗颅底脑膜瘤的临床疗效及安全性分析[J].局解手术学杂志,2026,35(06):528-533. DOI： 10.11659/jjssx.10E025109.

DONG Hai-jun,GUO Jun-xia,LIANG Sheng.Clinical efficacy and safety analysis of microsurgery combined with fluorescence navigation in the treatment of skull base meningiomas[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(06):528-533. DOI： 10.11659/jjssx.10E025109.

摘要

目的

评估显微手术联合荧光导航治疗颅底脑膜瘤的临床疗效及安全性。

方法

选择2023年6月至2025年3月在沧州市中心医院接受显微外科手术治疗的196例颅底脑膜瘤患者为研究对象，随机分为导航组和对照组，各98例。导航组患者接受荧光引导联合神经导航辅助下的显微外科手术治疗，对照组患者仅接受显微外科手术治疗。对比2组患者手术情况、临床疗效，评估术前及术后3个月2组患者神经功能评分、生活质量，统计2组患者并发症发生情况。

结果

导航组患者手术时间短于对照组，术中出血量少于对照组，全切除比例高于对照组，差异均具有统计学意义（

0.05）。2组患者总有效率比较，差异无统计学意义（

0.05）。术后3个月，2组患者格拉斯哥昏迷量表（GCS）评分、Karnofsky功能状态（KPS）评分均高于术前，且导航组高于对照组，差异均具有统计学意义（

0.05）。术后3个月，2组患者生理功能、躯体疼痛、一般健康情况、精神健康评分及简明健康状况调查问卷（SF-36）总评分均显著高于术前（

0.05），且导航组高于对照组（

0.05）；2组患者术后3个月生理职能、精力、社会功能、情感职能评分比较，差异均无统计学意义（

0.05）。2组患者术后3个月内并发症总发生率比较，差异无统计学意义（

0.05）。

结论

荧光引导联合神经导航辅助显微外科手术治疗颅底脑膜瘤安全有效。与单纯显微外科手术相比，该联合技术可显著缩短手术时间，减少术中出血量，提高肿瘤全切除率，更有效地促进患者术后神经功能恢复，并改善其生理功能、躯体疼痛、一般健康状况及精神健康维度的生活质量。

Abstract

Objective

To evaluate the clinical efficacy and safety of microsurgery combined with fluorescence navigation in the treatment of skull base meningiomas.

Methods

A total of 196 patients with skull base meningiomas who underwent microsurgical treatment in Cangzhou Central Hospital from June 2023 to March 2025 were selected and randomly divided into the navigation group and the control group，with 98 cases in each group.Patients in the navigation group received microsurgical treatment assisted by fluorescence guidance and neuronavigation，while patients in the control group received only microsurgical treatment. The surgical conditions and clinical efficacy of patients in the two groups were compared. The neurological function scores and quality of life of patients in the two groups before surgery and 3 months after surgery were evaluated. The occurrence of complications in the two groups of patients was statistically analyzed.

Results

The operation time of patients in the navigation group was shorter than that in the control group， the intraoperative blood loss was less than that in the control group， and the proportion of total resection was higher than that in the control group，the differences were all statistically significant （

0.05）.There was no statistically significant difference in the total effective rate between the two groups of patients（

0.05）. At 3 months after surgery，the Glasgow coma scale（GCS） score and Karnofsky performance status（KPS） score of both groups were higher than those before surgery， and the above scores of the navigation group were higher than those of the control group，the differences were statistically significant （

0.05）. At 3 months after surgery，the scores of physiological function， bodily pain， general health， mental health and the total score of the short-form-36 health survey questionnaire （SF-36） in both groups were significantly higher than those before surgery （

0.05）， and the above scores of the navigation group were higher than those of the control group （

0.05），but no statistically significant difference was observed in the scores of role-physical，vitality， social function and role-emotional of patients between the two groups 3 months after surgery （

0.05）. There was no statistically significant difference in the total incidence of complications within 3 months after surgery between the two groups of patients （

0.05）.

Conclusion

Fluorescence-guided combined with neuronavigation assisted microsurgical treatment for skull base meningiomas is safe and effective. Compared with simple microsurgery， this combined technique can significantly shorten the operation time， reduce intraoperative blood loss， increase the total tumor resection rate， more effectively promote the postoperative neurological function recovery of patients， and improve their quality of life in terms of physiological function， bodily pain， general health and mental health dimensions.

关键词

Keywords

references

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