Effects of anxiety or depression on the outcomes of laparoscopic bariatric surgery in obese patients

CHENG Xiao; SHEN Ting-yu; LI Min; CAO Guan-yi; LIU Guo-dong; CHENG Juan

doi:10.11659/jjssx.10E025065

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Effects of anxiety or depression on the outcomes of laparoscopic bariatric surgery in obese patients

Clinical Research | 更新时间：2026-05-25

- Effects of anxiety or depression on the outcomes of laparoscopic bariatric surgery in obese patients
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 35, Issue 5, Pages: 457-460(2026)
- 作者机构：
  
  1.江苏省人民医院宿迁医院健康管理中心，江苏宿迁 223800
  2.江苏省人民医院宿迁医院胃肠外科，江苏宿迁 223800
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.10E025065
  CLC： R656.6
- Received：22 October 2025，
  
  Published：25 May 2026
- 稿件说明：
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程肖,沈庭宇,李敏等.焦虑或抑郁情绪对肥胖患者腹腔镜下减重手术效果的影响[J].局解手术学杂志,2026,35(05):457-460.

CHENG Xiao,SHEN Ting-yu,LI Min,et al.Effects of anxiety or depression on the outcomes of laparoscopic bariatric surgery in obese patients[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(05):457-460.
程肖,沈庭宇,李敏等.焦虑或抑郁情绪对肥胖患者腹腔镜下减重手术效果的影响[J].局解手术学杂志,2026,35(05):457-460. DOI： 10.11659/jjssx.10E025065.

CHENG Xiao,SHEN Ting-yu,LI Min,et al.Effects of anxiety or depression on the outcomes of laparoscopic bariatric surgery in obese patients[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(05):457-460. DOI： 10.11659/jjssx.10E025065.

摘要

目的

探讨焦虑或抑郁情绪对肥胖患者腹腔镜下减重手术效果的影响。

方法

选取行腹腔镜下袖状胃切除减重手术治疗的112例肥胖患者为研究对象，根据术前3 d焦虑和抑郁情绪评分将患者分为焦虑或抑郁组（

=43）及正常情绪组（

=69）。对2组患者术前3 d、术后6个月和术后24个月的体质量指数（BMI）、腰臀比、血压、总胆固醇（TC）、三酰甘油（TG）、C反应蛋白（CRP）及白细胞介素-6（IL-6）进行比较。比较2组患者术后6个月和术后24个月的体质量反弹情况。

结果

2组患者在术前3 d和术后6个月的BMI、腰臀比、收缩压、舒张压及TC、TG、CRP和IL-6水平比较，差异均无统计学意义（

0.05）；术后24个月，焦虑或抑郁组患者的BMI、腰臀比、收缩压、舒张压及TC、TG、CRP和IL-6水平均显著大/高于正常情绪组（

0.05）。术后6个月，2组患者的体质量反弹率比较差异无显著统计学意义（

0.05）；而在术后24个月，焦虑或抑郁组患者的体质量反弹率显著高于正常情绪组（

0.05）。

结论

焦虑或抑郁情绪对肥胖患者腹腔镜下减重手术后短期减重效果影响小，而对术后较长时间减重效果影响显著。

Abstract

Objective

To investigate the effects of anxiety or depression on the outcomes of laparoscopic bariatric surgery in obese patients.

Methods

A total of 112 obese patients who underwent laparoscopic sleeve gastrectomy for weight loss were enrolled as research subjects. According to the anxiety and depression scores 3 days before surgery， patients were divided into the anxiety or depression group （

=43） and the normal mood group （

=69）. The body mass index （BMI）， waist-hip ratio， blood pressure， total cholesterol （TC）， triacylglycerol （TG）， C-reactive protein （CRP）， and interleukin-6 （IL-6） were compared between the two groups at 3 days preoperatively， 6 months postoperatively， and 24 months postoperatively. The body weight rebound at 6 months and 24 months postoperatively was compared between the two groups.

Results

There was no significant difference in BMI， waist-hip ratio， systolic blood pressure， diastolic blood pressure，or levels of TC， TG， CRP， and IL-6 between the two groups at 3 days preoperatively and 6 months postoperatively （

0.05）. At 24 months postoperatively， the anxiety or depression group had significantly higher BMI， waist-hip ratio， systolic blood pressure， diastolic blood pressure，and levels of TC， TG， CRP， and IL-6 than the normal mood group （

0.05）. No significant difference in body weight rebound rate was observed between the two groups at 6 months postoperatively （

0.05）， whereas the body weight rebound rate in the anxiety or depression group was significantly higher than that in the normal mood group at 24 months postoperatively （

0.05）.

Conclusion

Anxiety or depression has little impact on the short-term weight loss outcome of laparoscopic bariatric surgery in obese patients， while exerts a significant effect on the long-term weight loss outcome.

关键词

Keywords

references

中国营养学会肥胖防控分会专家组，王友发，田向阳，等 . 中国居民健康体重管理之减重行动20条：基于科学循证的专家建议共识［J］. 中国预防医学杂志， 2023 ， 24 （ 11 ）： 1137 - 1144 . doi： 10.16506/j.1009-6639.2023.11.001 http://dx.doi.org/10.16506/j.1009-6639.2023.11.001 .

Shi Q ， Wang Y ， Hao Q ， et al . Pharmacotherapy for adults with overweight and obesity：a systematic review and network meta-analysis of randomised controlled trials ［J］. Lancet ， 2024 ， 403 （ 10434 ）： e21 - e31 . doi： 10.1016/S0140-6736（24）00351-9 http://dx.doi.org/10.1016/S0140-6736（24）00351-9 .

Aronne LJ ， Sattar N ， Horn DB ， et al . Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity：the SURMOUNT-4 randomized clinical trial ［J］. JAMA ， 2024 ， 331 （ 1 ）： 38 - 48 . doi： 10.1001/jama.2023.24945 http://dx.doi.org/10.1001/jama.2023.24945 .

彭成娟，黄洁，周启阳，等 . 腹腔镜单吻合口胃旁路术治疗肥胖与代谢综合征的近期疗效［J］. 中华普通外科杂志， 2024 ， 39 （ 4 ）： 263 - 267 . doi： 10.3760/cma.j.cn113855-20231105-00308 http://dx.doi.org/10.3760/cma.j.cn113855-20231105-00308 .

Juca RH ， Bregion PB ， de Oliveira-Filho JR ， et al . Comparative analysis of renal function outcomes following sleeve gastrectomy and Roux-en-Y gastric bypass：a systematic review and meta-analysis ［J］. Obes Surg ， 2025 ， 35 （ 2 ）： 587 - 601 . doi： 10.1007/s11695-025-07669-z http://dx.doi.org/10.1007/s11695-025-07669-z .

许艳，窦翊愷，王敏，等 . 肥胖患者情绪异常与减重手术效果的相关性［J］. 四川精神卫生， 2024 ， 37 （ 1 ）： 46 - 51 . doi： 10.11886/scjsws20231220002 http://dx.doi.org/10.11886/scjsws20231220002 .

Jacobs A ， Monpellier VM ， Torensma B ， et al . Influence of mental and behavioral factors on weight loss after bariatric surgery：a systematic review and meta-analysis ［J］. Obes Rev ， 2024 ， 25 （ 6 ）： e13729 . doi： 10.1111/obr.13729 http://dx.doi.org/10.1111/obr.13729 .

Woods R ， Moga AM ， Ribeiro PAB ， et al . Evolution of depressive symptoms from before to 24 months after bariatric surgery：a systematic review and meta-analysis ［J］. Obes Rev ， 2023 ， 24 （ 5 ）： e13557 . doi： 10.1111/obr.13557 http://dx.doi.org/10.1111/obr.13557 .

中华医学会外科学分会甲状腺及代谢外科学组，中国医师协会外科医师分会肥胖和糖尿病外科医师委员会 . 中国肥胖及2型糖尿病外科治疗指南（2019版）［J］. 中国实用外科杂志， 2019 ， 39 （ 4 ）： 301 - 306 . doi： 10.19538/j.cjps.issn1005-2208.2019.04.01 http://dx.doi.org/10.19538/j.cjps.issn1005-2208.2019.04.01 .

Pereira AM ， Pereira SS ， Monteiro MP ， et al . Is single anastomosis duodenoileal bypass （SADI） an effective option for conversional surgery following sleeve gastrectomy？ A comprehensive review and revised scope of current literature ［J］. Obes Res Clin Pract ， 2025 ， 19 （ 1 ）： 1 - 10 . doi： 10.1016/j.orcp.2025.01.005 http://dx.doi.org/10.1016/j.orcp.2025.01.005 .

何杰，蔺原，周军，等 . 腹腔镜下袖状胃切除术治疗肥胖合并2型糖尿病的临床疗效［J］. 中国现代普通外科进展， 2025 ， 28 （ 1 ）： 59 - 61 . doi： 10.3969/j.issn.1009-9905.2025.01.012 http://dx.doi.org/10.3969/j.issn.1009-9905.2025.01.012 .

Sánchez-Pernaute A ， Rubio Herrera MA ， Pérez-Aguirre E ， et al . Proximal duodenal-ileal end-to-side bypass with sleeve gastrectomy：proposed technique ［J］. Obes Surg ， 2007 ， 17 （ 12 ）： 1614 - 1618 . doi： 10.1007/s11695-007-9287-8 http://dx.doi.org/10.1007/s11695-007-9287-8 .

Gong M ， Fang Y ， Yang K ， et al . The WFS1-ZnT3-Zn 2+ axis regulates the vicious cycle of obesity and depression ［J］. Adv Sci （Weinh）， 2024 ， 11 （ 41 ）： e2403405 . doi： 10.1002/advs.202403405 http://dx.doi.org/10.1002/advs.202403405 .

刘美玲，程志强，刘渌如，等 . 中青年肥胖患者减重心理痛苦现状及影响因素研究［J］. 医药导报， 2025 ， 44 （ 12 ）： 1922 - 1926 . doi： 10.3870/j.issn.1004-0781.2025.12.007 http://dx.doi.org/10.3870/j.issn.1004-0781.2025.12.007 .

Bali A ， Jaggi AS . An integrative review on role and mechanisms of ghrelin in stress，anxiety and depression ［J］. Curr Drug Targets ， 2016 ， 17 （ 5 ）： 495 - 507 . doi： 10.2174/1389450116666150518095650 http://dx.doi.org/10.2174/1389450116666150518095650 .

Lawson EA ， Miller KK ， Blum JI ， et al . Leptin levels are associated with decreased depressive symptoms in women across the weight spectrum，independent of body fat ［J］. Clin Endocrinol （Oxf）， 2012 ， 76 （ 4 ）： 520 - 525 . doi： 10.1111/j.1365-2265.2011.04182.x http://dx.doi.org/10.1111/j.1365-2265.2011.04182.x .

Deuschle M ， Gilles M . Hypercortisolemic depressed women：lean but viscerally obese？［J］. Neuroendocrinology ， 2016 ， 103 （ 3/4 ）： 263 - 268 . doi： 10.1159/000437168 http://dx.doi.org/10.1159/000437168 .

Kuckuck S ， Lengton R ， Meeusen REH ， et al . Perceived stress，hair cortisol，and hair cortisone in relation to appetite-regulating hormones in patients with obesity ［J］. Obes Facts ， 2025 ， 18 （ 2 ）： 206 - 214 . doi： 10.1159/000542079 http://dx.doi.org/10.1159/000542079 .

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