Effect of remifentanil infusion at different speed on propofol injection pain

LIU Han; QIN Qin; OUYANG Xin-cheng; CUI Jing-wei

doi:10.11659/jjssx.10E024021

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Effect of remifentanil infusion at different speed on propofol injection pain

Clinical Research | 更新时间：2025-07-31

- Effect of remifentanil infusion at different speed on propofol injection pain
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 8, Pages: 715-718(2025)
- 作者机构：
  
  广州市中西医结合医院麻醉科，广东广州 510800
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.10E024021
  CLC： R614.2
- Received：10 October 2024，
  
  Published：25 August 2025
- 稿件说明：
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刘晗,秦勤,欧阳锌澄等.不同速度输注瑞芬太尼对丙泊酚注射痛的影响[J].局解手术学杂志,2025,34(08):715-718.

LIU Han,QIN Qin,OUYANG Xin-cheng,et al.Effect of remifentanil infusion at different speed on propofol injection pain[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(08):715-718.
刘晗,秦勤,欧阳锌澄等.不同速度输注瑞芬太尼对丙泊酚注射痛的影响[J].局解手术学杂志,2025,34(08):715-718. DOI： 10.11659/jjssx.10E024021.

LIU Han,QIN Qin,OUYANG Xin-cheng,et al.Effect of remifentanil infusion at different speed on propofol injection pain[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(08):715-718. DOI： 10.11659/jjssx.10E024021.

摘要

目的

探讨不同速度输注瑞芬太尼对丙泊酚注射痛的影响。

方法

选择我院200例行全身麻醉气管插管下择期手术患者，采用随机数字表法分为C组、R2组、R3组、R4组和R5组，每组40例，分别按0 μg·kg

-1

·min

-1

、0.2 μg·kg

-1

·min

-1

、0.3 μg·kg

-1

·min

-1

、0.4 μg·kg

-1

·min

-1

、0.5 μg·kg

-1

·min

-1

输注瑞芬太尼，在输注瑞芬太尼2 min后，开始靶控输注效应室浓度为2.5 μg/mL的丙泊酚。比较5组患者丙泊酚注射痛发生率、注射痛程度、输注瑞芬太尼前及气管插管前心率和平均动脉压；记录患者低血压、心动过缓、胸壁僵硬等并发症发生情况。

结果

R2组、R3组、R4组和R5组患者丙泊酚注射痛发生率及注射痛程度低于C组（

0.05）；R4组丙泊酚注射痛发生率显著低于R2组、R3组，注射痛程度低于R2组（

0.05）；R5组患者丙泊酚注射痛发生率及注射痛程度低于R2组、R3组（

0.05）。然而，R2组和R3组间、R4组和R5组间的注射痛发生率及注射痛程度差异均无统计学意义（

0.05）。各组患者均未出现需要药物治疗的低血压、心动过缓、脉搏氧饱和度下降、胸壁僵硬等并发症，亦无患者术后24 h内出现注射部位疼痛、水肿和红肿等不良反应。

结论

在丙泊酚用药前2 min开始匀速输注0.4 μg·kg

-1

·min

-1

、0.5 μg·kg

-1

·min

-1

的瑞芬太尼对减少丙泊酚注射痛效果良好，且不会引起严重并发症。

Abstract

Objective

To investigate the influence of remifentanil infusion at different speed on propofol injection pain.

Methods

Totally 200 patients who accepted elective surgery under general anesthesia with tracheal intubation were selected. The patients were divided into C group，R2 group，R3 group， R4 group and R5 group by random number table method， with 40 patients in each group，and they were injected with remifentanil at a constant rate of 0 μg·kg

-1

·min

-1

，0.2 μg·kg

-1

·min

-1

， 0.3 μg·kg

-1

·min

-1

， 0.4 μg·kg

-1

·min

-1

， and 0.5 μg·kg

-1

·min

-1

， respectively.After 2 minutes of remifentanil infusion， a target controlled infusion of propofol at an effect-site concentration of 2.5 μg/mL was initiated. The incidence of propofol injection pain，the severity of injection pain， heart rate and mean arterial pressure before remifentanil infusion and before tracheal intubation were compared among the 5 groups.The incidence of complications such as hypotension， bradycardia and chest wall stiffness of patients was recorded.

Results

The incidence and the severity of propofol injection pain of patients in R2 group， R3 group， R4 group and R5 group were significantly lower than those in C group （

0.05）.The incidence of propofol injection pain of patients in R4 group was significantly lower than those in R2 group and R3 group， and the severity of propofol injection pain of patients in R4 group was significantly lower than that in R2 group （

0.05）.The incidence and the severity of propofol injection pain of patients in R5 group was significantly lower than those in R2 group and R3 group （

0.05）.However， there were no statistically significant differences in the incidence or severity of injection pain between R2 group and R3 group， and between R4 group and R5 group（

0.05）.None of the patients in each group had complications such as hypotension， bradycardia， decreased pulse oxygen saturation， and chest wall stiffness that required drug treatment. And there was no adverse reactions such as pain， edema， redness at the injection site occurred within 24 hours after operation.

Conclusion

Remifentanil infused at a constant rate of 0.4 μg·kg

-1

·min

-1

and 0.5 μg·kg

-1

·min

-1

starting at 2 minutes before propofol administration is effective in reducing propofol injection pain without causing serious complications.

关键词

Keywords

references

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