Efficacy of multiple-point thoracic drainage combined with urokinase injection in the treatment of complicated pleural effusion

WU Bo; HU Jian; TANG Xing-song; BAI Mao-shu

doi:10.11659/jjssx.09E025017

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Efficacy of multiple-point thoracic drainage combined with urokinase injection in the treatment of complicated pleural effusion

Clinical Research | 更新时间：2026-05-25

- Efficacy of multiple-point thoracic drainage combined with urokinase injection in the treatment of complicated pleural effusion
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 35, Issue 5, Pages: 445-448(2026)
- 作者机构：
  
  达州市中西医结合医院胸外科，四川达州 635000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.09E025017
  CLC： R561
- Received：05 September 2025，
  
  Published：25 May 2026
- 稿件说明：
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吴博,胡健,汤兴松等.多点位胸腔引流联合尿激酶注射治疗复杂性胸腔积液的疗效观察[J].局解手术学杂志,2026,35(05):445-448.

WU Bo,HU Jian,TANG Xing-song,et al.Efficacy of multiple-point thoracic drainage combined with urokinase injection in the treatment of complicated pleural effusion[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(05):445-448.
吴博,胡健,汤兴松等.多点位胸腔引流联合尿激酶注射治疗复杂性胸腔积液的疗效观察[J].局解手术学杂志,2026,35(05):445-448. DOI： 10.11659/jjssx.09E025017.

WU Bo,HU Jian,TANG Xing-song,et al.Efficacy of multiple-point thoracic drainage combined with urokinase injection in the treatment of complicated pleural effusion[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(05):445-448. DOI： 10.11659/jjssx.09E025017.

摘要

目的

探讨多点位胸腔引流并胸腔内注入尿激酶治疗复杂性胸腔积液的疗效。

方法

选取我院2024年3－12月收治的135例复杂性胸腔积液患者，按照引流方法不同分为多点位引流组、单点位引流+尿激酶组、多点位引流+尿激酶组，每组45例。多点位引流组患者采用多点位胸腔引流，单点位引流+尿激酶组患者采用单点位胸腔引流并胸腔内注入尿激酶，多点位引流+尿激酶组患者采用多点位胸腔引流加胸腔内注入尿激酶。比较各组患者胸腔积液吸收时间、气促缓解时间、住院时间、炎症指标及出院后2个月胸膜厚度。

结果

各组患者胸腔积液吸收时间、气促缓解时间及住院时间对比差异有统计学意义（

0.05），其中多点位引流+尿激酶组患者胸腔积液吸收时间、气促缓解时间及住院时间短于多点位引流组和单点位引流+尿激酶组（

0.05）。各组患者治疗后红细胞沉降率、C反应蛋白水平对比差异有统计学意义（

0.05），其中多点位引流+尿激酶组患者治疗后上述炎症指标水平低于多点位引流组和单点位引流+尿激酶组（

0.05）。各组患者出院后2个月胸膜厚度对比差异有统计学意义（

0.05），其中多点位引流+尿激酶组患者出院后2个月胸膜厚度小于多点位引流组和单点位引流+尿激酶组（

0.05）。

结论

多点位胸腔引流联合尿激酶注射的方案在复杂性胸腔积液的治疗中能够加快胸腔积液的吸收和引流，显著改善胸膜厚度及炎症水平，为胸膜病变的治疗提供了新的思路和方法。

Abstract

Objective

To investigate the efficacy of multiple-point thoracic drainage combined with intrapleural injection of urokinase in the treatment of complicated pleural effusion.

Methods

A total of 135 patients with complicated pleural effusion admitted to our hospital from March to December 2024 were selected and divided into the multiple-point drainage group， single-point drainage+urokinase group， and multiple-point drainage+urokinase group based on drainage methods，with 45 cases in each group. Patients in the multiple-point drainage group received multiple-point thoracic drainage alone； those in the single-point drainage+urokinase group received single-point thoracic drainage combined with intrapleural injection of urokinase； and those in the multiple-point drainage+urokinase group received multiple-point thoracic drainage plus intrapleural injection of urokinase. The pleural effusion absorption time， time to relief of shortness of breath， hospital stay，inflammatory indicators，and pleural thickness 2 months after discharge were compared in each group.

Results

Statistically significant differences were found in the pleural effusion absorption time， time to relief of shortness of breath，and hospital stay among groups （

0.05）； among them， the multiple-point drainage+urokinase group exhibited shorter pleural effusion absorption time，time to relief of shortness of breath，and hospital stay compared to the multiple-point drainage group and the single-point drainage+urokinase group （

0.05）. There were statistically significant differences in the erythrocyte sedimentation rate and level of C-reactive protein after treatment among groups （

0.05）； among them，the multiple-point drainage+urokinase group showed lower levels of these inflammatory indicators after treatment compared to the multiple-point drainage group and the single-point drainage+urokinase group （

0.05）. There was a statistically significant difference in pleural thickness 2 months after discharge among groups （

0.05）； among them， the multiple-point drainage+urokinase group had reduced pleural thickness 2 months after discharge compared to the multiple-point drainage group and the single-point drainage+urokinase group （

0.05）.

Conclusion

The regimen of multiple-point pleural drainage combined with urokinase injection can accelerate the absorption and drainage of pleural effusion in the treatment of complicated pleural effusion. It can also significantly reduce the pleural thickness and alleviate inflammation，providing a new approach and method for the treatment of pleural lesions.

关键词

Keywords

references

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