Prognostic value of mitochondrial MT-ND family genes in cancer based on a pan-cancer analysis
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 5, Pages: 395-400(2025)
- 作者机构：
吉林大学白求恩第一医院普通外科中心结直肠肛门外科，吉林 长春 130021
- 作者简介：
- 基金信息：
DOI：10.11659/jjssx.09E024138
CLC： Q786;R730Received：26 September 2024，
Published：25 May 2025
- 稿件说明：
移动端阅览
张海佳,陈思,常程等.基于泛癌分析的线粒体MT-ND家族基因在癌症中的预后价值[J].局解手术学杂志,2025,34(05):395-400.
ZHANG Hai-jia,CHEN Si,CHANG Cheng,et al.Prognostic value of mitochondrial MT-ND family genes in cancer based on a pan-cancer analysis[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(05):395-400.
张海佳,陈思,常程等.基于泛癌分析的线粒体MT-ND家族基因在癌症中的预后价值[J].局解手术学杂志,2025,34(05):395-400. DOI： 10.11659/jjssx.09E024138.
ZHANG Hai-jia,CHEN Si,CHANG Cheng,et al.Prognostic value of mitochondrial MT-ND family genes in cancer based on a pan-cancer analysis[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(05):395-400. DOI： 10.11659/jjssx.09E024138.
摘要
目的
2
探讨MT-ND家族在泛癌中的异常表达及其预后价值。
方法
2
从TCGA数据库下载33种癌症类型的转录组表达和临床信息数据，分析不同癌症类型中MT-ND家族在癌组织与正常组织中的表达差异。采用单因素
Cox
回归分析和
Kaplan
-
Meier
生存分析探讨MT-ND家族在泛癌中的预后作用。
结果
2
MT-ND家族在肾嫌色细胞癌、急性髓性白血病和胸腺瘤中表达上调，在其余肿瘤中表达下调。MT-ND家族的表达与不同癌症类型的总生存率有关。此外，MT-ND家族成员均与免疫侵袭亚型显著相关，并与基质细胞侵袭和肿瘤细胞干性有不同程度的相关性。在低级别脑胶质瘤中，MT-ND4表达下调，且是预后的保护因子；而MT-ND4在胸腺癌中表达上调，是预后的危险因子。
结论
2
经过泛癌分析证实，MT-ND家族可预测肿瘤预后，为癌症的精准治疗和预后管理提供了新的思路和策略。
Abstract
Objective
2
To explore the abnormal expression of the MT-ND family in pan-cancers and its prognostic value.
Methods
2
Transcriptome expression and clinical data of 33 cancers were downloaded from the TCGA database，thereby analyzing the expression differences of the MT-ND family in tissuesof different types of cancers and normal tissues. The prognostic role of the MT-ND family in pan-cancers was explored by univariate
Cox
regression analysis and
Kaplan
-
Meier
survival analysis.
Results
2
The expression of the MT-ND family was upregulated in the kidney chromophobe，acute myeloid leukemia and thymoma，and downregulated in the remaining tumors. The expression of the MT-ND family was associated with the overall survival rate of different types of cancers. In addition，the MT-ND family were significantly correlated with the immune invasion subtypes，and were correlated with stromal cell invasion and tumor cell stemness to varying degrees. The expression of MT-ND4 was downregulated in brain lower grade glioma，which was a protective factor for prognosis； while the expression of MT-ND4 in thymoma was upregulated，which was a risk factor for prognosis.
Conclusion
2
Pan-cancer analysis has confirmed that the MT-ND family can predict the tumor prognosis，which provides new ideas and strategies for the precision treatment and prognostic management of cancer.
关键词
Keywords
references
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