Analysis on influencing factors of secondary epidural fluid collection after cranioplasty

DENG Qian; ZHANG Qian; ZHANG Zhan-wei; YI Qin; LI Huan

doi:10.11659/jjssx.08E025029

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Analysis on influencing factors of secondary epidural fluid collection after cranioplasty

Clinical Research | 更新时间：2026-05-25

- Analysis on influencing factors of secondary epidural fluid collection after cranioplasty
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 35, Issue 5, Pages: 449-452(2026)
- 作者机构：
  
  湖南中医药大学第一附属医院神经外科，湖南长沙 410000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.08E025029
  CLC： R651.1
- Received：06 August 2025，
  
  Published：25 May 2026
- 稿件说明：
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邓茜,张茜,张占伟等.颅骨修补术后继发硬脑膜外积液的影响因素分析[J].局解手术学杂志,2026,35(05):449-452.

DENG Qian,ZHANG Qian,ZHANG Zhan-wei,et al.Analysis on influencing factors of secondary epidural fluid collection after cranioplasty[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(05):449-452.
邓茜,张茜,张占伟等.颅骨修补术后继发硬脑膜外积液的影响因素分析[J].局解手术学杂志,2026,35(05):449-452. DOI： 10.11659/jjssx.08E025029.

DENG Qian,ZHANG Qian,ZHANG Zhan-wei,et al.Analysis on influencing factors of secondary epidural fluid collection after cranioplasty[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(05):449-452. DOI： 10.11659/jjssx.08E025029.

摘要

目的

探讨颅骨修补术后继发硬脑膜外积液（EFC）的影响因素。

方法

回顾性分析2022年6月至2024年6月我院收治的96例使用钛网行颅骨修补术后继发EFC患者的临床资料。根据术后6个月是否继发EFC，将患者分成继发EFC组（30例）和未继发EFC组（66例）。采用单因素分析和多因素

Logistic

回归分析颅骨修补术后继发EFC的影响因素。

结果

与未继发EFC组相比，继发EFC组患者手术时间延长，术中出血量、缺损面积、骨窗凹陷深度、潜在无效腔体积增加，硬脑膜破损、硬脑膜外钙化占比升高，差异均有统计学意义（

0.05）。多因素

Logistic

回归分析显示，手术时间长（

=1.931，95%

：1.204~3.268），术中出血量（

=1.972，95%

：1.089~3.430）、缺损面积（

=1.956，95

%CI

：1.215~3.085）、骨窗凹陷深度（

=2.020，95%

CI：

1.208~4.750）、潜在无效腔体积（

=2.962，95%

：1.161~7.556）增加，合并硬脑膜破损（

=1.976，95%

：1.227~2.852）及硬脑膜外钙化（

=1.910，95%

：1.120~3.005）均是颅骨修补术后继发EFC的独立危险因素（

0.05）。

结论

颅骨修补术后EFC的形成可能与手术创伤反应及局部解剖结构适配性相关，手术时间、术中出血量、硬脑膜破损在早期EFC发生中起主导作用，而缺损面积、骨窗凹陷深度、潜在无效腔体积对迟发性EFC的影响更为显著。

Abstract

Objective

To explore the influencing factors of secondary epidural fluid collection （EFC） after cranioplasty.

Methods

A retrospective analysis was conducted on the clinical data of 96 patients

who developed secondary EFC following cranioplasty with titanium mesh in our hospital from June 2022 to June 2024. Based on whether there was secondary EFC 6 months after surgery，the patients were divided into the secondary EFC group（

=30） and the non-secondary EFC group（

=66）.Univariate analysis and multivariate

Logistic

regression analysis were used to analyze the influencing factors of secondary EFC after cranioplasty.

Results

Compared with the non-secondary EFC group，the operation time of patients in the secondary EFC group was prolonged， the intraoperative blood loss， defect area，depth of bone window depression，potential dead space volume were increased，and the proportions of dural defects and epidural calcification were elevated，the differences were statistically significant （

0.05）. Multivariate

Logistic

regression analysis showed that the longer operation time （

=1.931，95%

：1.204 to 3.268），more intraoperative blood loss （

=1.972，95%

：1.089 to 3.430），large defect area （

=1.956，95%

：1.215 to 3.085），the increased depth of bone window depression （

=2.020，95%

：1.208 to 4.750），the large potential dead space volume （

=2.962， 95%

： 1.161 to 7.556），and presence of dural defects （

=1.976， 95%

：1.227 to 2.852） and epidural calcification （

=1.910，95%

：1.120 to 3.005） were the independent risk factors for secondary EFC after cranioplasty （

0.05）.

Conclusion

The development of EFC following cranioplasty appears to be associated with both surgical trauma response and local anatomical compatibility. The operation time， intraoperative blood loss and dural defects play a leading role in the occurrence of early EFC， while the defect area， the depth of bone window depression and the potential dead space volume have a more significant impact on delayed EFC.

关键词

Keywords

references

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