Effects of different CO₂ pneumoperitoneum pressures on clinical outcomes of laparoscopic bariatric surgery in obese patients

LU Xuan; XU Xu; XU Huan-xi; LI Xian-rui; GU Xiao-hui; WU Hao

doi:10.11659/jjssx.08E025003

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Effects of different CO₂ pneumoperitoneum pressures on clinical outcomes of laparoscopic bariatric surgery in obese patients

Clinical Research | 更新时间：2026-05-25

- Effects of different CO₂ pneumoperitoneum pressures on clinical outcomes of laparoscopic bariatric surgery in obese patients
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 35, Issue 5, Pages: 441-444(2026)
- 作者机构：
  
  江苏省人民医院宿迁医院麻醉与围术期医学科，江苏宿迁 223800
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.08E025003
  CLC： R614.2
- Received：03 August 2025，
  
  Published：25 May 2026
- 稿件说明：
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陆璇,许旭,徐幻浠等.不同CO₂气腹压力对肥胖患者腹腔镜下减重手术效果的影响[J].局解手术学杂志,2026,35(05):441-444. DOI: 10.11659/jjssx.08E025003.

LU Xuan,XU Xu,XU Huan-xi,et al.Effects of different CO₂ pneumoperitoneum pressures on clinical outcomes of laparoscopic bariatric surgery in obese patients[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(05):441-444.
陆璇,许旭,徐幻浠等.不同CO₂气腹压力对肥胖患者腹腔镜下减重手术效果的影响[J].局解手术学杂志,2026,35(05):441-444. DOI: 10.11659/jjssx.08E025003. DOI：

LU Xuan,XU Xu,XU Huan-xi,et al.Effects of different CO₂ pneumoperitoneum pressures on clinical outcomes of laparoscopic bariatric surgery in obese patients[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(05):441-444. DOI： 10.11659/jjssx.08E025003.

摘要

目的

评价不同CO

气腹压力对肥胖患者腹腔镜下减重手术急性肺损伤、苏醒质量及疼痛的影响。

方法

选取我院行腹腔镜下袖状胃切除减重手术的肥胖患者70例为研究对象，随机分为高压组和低压组，每组35例，术中CO

气腹压力分别维持在16 mmHg和12 mmHg。对2组患者的手术情况、呼吸力学指标、炎症因子水平、全身麻醉苏醒情况及疼痛情况进行比较。

结果

2组患者的手术时间、术中出血量、术中丙泊酚用量、术中瑞芬太尼用量及术中罗库溴铵用量比较，差异均无统计学意义（

0.05）。在手术60 min，低压组患者的气道峰压（Ppeak）及气道平台压（Pplat）均显著低于高压组（

0.05）。低压组患者在机械通气结束即刻的肿瘤坏死因子α（TNF-α）及白细胞介素-6（IL-6）水平均显著低于高压组（

0.05）。低压组患者的自主呼吸恢复时间、苏醒时间、气管拔管时间及麻醉苏醒室停留时间均显著短于高压组（

0.05）。在术后12 h和24 h，低压组患者的疼痛评分均显著低于高压组（

0.05）。低压组患者术后48 h内补救镇痛舒芬太尼用量显著少于高压组(

0.05)。

结论

对于行腹腔镜下减重手术的肥胖患者，与16 mmHg的CO

气腹压力相比，12 mmHg的CO

气腹压力不增加手术难度及麻醉药物用量，患者苏醒质量更好，急性肺损伤及术后疼痛更轻。

Abstract

Objective

To evaluate the effects of different CO₂ pneumoperitoneum pressures on acute lung injury，recovery quality，and pain in obese patients undergoing laparoscopic bariatric surgery.

Methods

A total of 70 obese patients who underwent laparoscopic sleeve gastrectomy bariatric surgery at our hospital were selected as the study subjects and randomly divided into the high-pressure group （

=35） and the low-pressure group （

=35）， with intraoperative CO₂ pneumoperitoneum pressure at 16 mmHg and 12 mmHg， respectively.The surgical conditions， respiratory mechanics indicators， inflammatory factor levels， general anesthesia recovery status， and pain status were compared between the two groups.

Results

There were no statistically significant differences between the two groups in terms of operation time， intraoperative blood loss， intraoperative dosage of propofol， intraoperative dosage of remifentanil， and intraoperative dosage of rocuronium bromide （

0.05）.At 60 minutes of operation， the peak airway pressure （Ppeak） and plateau airway pressure （Pplat） of patients in the low-pressure group were significantly lower than those in the high-pressure group （

0.05）. Immediately after mechanical ventilation， the levels of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） of patients in the low-pressure group were significantly lower than those in the high-pressure group （

0.05）.The time to spontaneous breathing recovery， awakening time， tracheal extubation time， and length of stay in the post-anesthesia care unit of patients in the low-pressure group were significantly shorter than those in the high-pressure group （

0.05）.At 12 and 24 hours after surgery， pain scores of patients in the low-pressure group were significantly lower than those in the high-pressure group （

0.05）.The dosage of sufentanil for rescue analgesia within 48 hours after surgery of patients in the low-pressure group was significantly less than that in the high-pressure gro

up （

0.05）.

Conclusion

For obese patients undergoing laparoscopic bariatric surgery， compared with a CO₂ pneumoperitoneum pressure of 16 mmHg， 12 mmHg CO₂ pneumoperitoneum pressure does not increase the difficulty of surgery or the dosage of anesthetic drugs， resulting in better recovery quality， milder acute lung injury， and less postoperative pain.

关键词

Keywords

references

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