Application progress of micro-CT and finite element analysis techniques in scaphoid bone research

LYU Yuan; ZHANG De-zhou; QIAN Hai-long; WANG Si-min; WANG Chao-qun; LI Kun; CHEN Jie; BAI Xue; ZHAO Hai-long; ZHANG Shao-jie; MA Yuan; LI Zhi-jun; SHI Jun; WANG Xing

doi:10.11659/jjssx.08E024097

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Application progress of micro-CT and finite element analysis techniques in scaphoid bone research

Review | 更新时间：2025-01-21

- Application progress of micro-CT and finite element analysis techniques in scaphoid bone research
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 2, Pages: 168-172(2025)
- 作者机构：
  
  1.内蒙古医科大学研究生院，内蒙古呼和浩特 010110
  2.包头市肿瘤医院微创肿瘤介入外科，内蒙古包头 014030
  3.内蒙古医科大学附属医院影像科，内蒙古呼和浩特 010050
  4.内蒙古医科大学基础医学院解剖学教研室，内蒙古呼和浩特 010110
  5.内蒙古医科大学基础医学院数字医学中心/内蒙古自治区数字转化医学工程技术研究中心，内蒙古呼和浩特 010059
  6.内蒙古医科大学基础医学院生理学教研室，内蒙古呼和浩特 010110
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.08E024097
  CLC： R687.3
- Published：25 February 2025，
  
  Received：25 August 2024，
- 稿件说明：
移动端阅览
LYU YUAN, ZHANG DE-ZHOU, QIAN HAI-LONG, et al. Application progress of micro-CT and finite element analysis techniques in scaphoid bone research. [J]. Journal of regional anatomy and operative surgery, 2025, 34(2): 168-172.
DOI：

LYU YUAN, ZHANG DE-ZHOU, QIAN HAI-LONG, et al. Application progress of micro-CT and finite element analysis techniques in scaphoid bone research. [J]. Journal of regional anatomy and operative surgery, 2025, 34(2): 168-172. DOI： 10.11659/jjssx.08E024097.

摘要

手舟骨是手部的重要骨骼之一，在临床上损伤频发且治疗具有一定难度。因此，深入研究手舟骨的微观结构和生物力学特征对了解其损伤机制和优化治疗方案至关重要。微计算机断层扫描(micro-CT)技术提供了高分辨率的骨组织成像，而有限元分析则能帮助模拟手舟骨在不同生理和病理状态下的应力分布和行为模式。通过micro-CT技术获取手舟骨的高分辨率三维图像，能够用于构建手舟骨真实解剖结构的有限元模型，从而实现对手舟骨力学性能的精确模拟。这两种先进技术的融合为揭示手舟骨的结构功能关系及其损伤机制提供了新视角。因此，本文回顾了手舟骨的解剖学特征及其在不同状态下的生物力学行为，并重点讨论了micro-CT和有限元分析技术在手舟骨研究中的具体应用及其优势，通过综述近几年来的研究成果，为手舟骨相关疾病的诊断、治疗及预防提供新的科学依据和方法。

Abstract

The scaphoid bone is one of the important bone of hand，which is frequently injured and difficult to treat in clinical practice. Therefore，it is very important to deeply study the microstructure and biomechanical characteristics of the scaphoid bone for understanding its injury mechanism and optimizing treatment scheme. Microcomputed tomography （micro-CT） provides high-resolution imaging of bone tissue，while finite element analysis can help to simulate the stress distribution and behavioral patterns of the scaphoid bone under various physiological and pathological states. The high-resolution three-dimensional image of the scaphoid bone obtained by micro-CT technology can be used to construct finite element models of real anatomical structure of the scaphoid bone，thus achieving accurate simulation of the mechanical properties of the scaphoid bone. The fusion of these two advanced technologies provides a new perspective for revealing the structural and functional relationships and injury mechanism of the scaphoid bone. Therefore，this paper reviews the anatomical characteristics of the scaphoid bone and its biomechanical behavior in different states，emphasizing the specific applications and advantages of micro-CT and finite element analysis techniques in the study of the scaphoid bone. By summarizing the research findings in recent years，this paper provides novel scientific basis and methods for the diagnosis，treatment，and prevention of scaphoid bone-related disorders.

关键词

手舟骨微观结构生物力学micro-CT有限元分析基础研究临床研究研究进展

Keywords

scaphoid bonemicrostructurebiomechanicsmicro-CTfinite element analysisbasic researchclinical researchresearch progress

references

Fowler JR，Hughes TB.Scaphoid fractures［J］.Clin Sports Med，2015，34（1）：37-50.doi：10.1016/j.csm.2014.09.011http://dx.doi.org/10.1016/j.csm.2014.09.011.

Sabbagh MD，Morsy M，Moran SL.Diagnosis and management of acute scaphoid fractures［J］.Hand Clin，2019，35（3）：259-269.doi：10.1016/j.hcl.2019.03.002http://dx.doi.org/10.1016/j.hcl.2019.03.002.

Xiong G.The vascular anatomy of the scaphoid：vascular illustration and classification［J］.J Hand Surg Am，2020，45（8）：e7.doi：10.1016/j.jhsa.2020.04.016http://dx.doi.org/10.1016/j.jhsa.2020.04.016.

沈重成，王鼎予，方璇，等.微CT构建人手舟骨骨内血管高精度三维模型［J］.解剖学报，2020，51（4）：557-560.doi：10.16098/j.issn.0529-1356.2020.04.014http://dx.doi.org/10.16098/j.issn.0529-1356.2020.04.014.

Bevers M，Daniels AM，Van Rietbergen B，et al.Assessment of the healing of conservatively-treated scaphoid fractures using HR-pQCT［J］.Bone，2021，153：116161.doi：10.1016/j.bone.2021.116161http://dx.doi.org/10.1016/j.bone.2021.116161.

Burnier M，Loisel F，Ardouin L，et al.Treatment of scaphoid nonunion by arthroscopic cancellous bone grafting［J］.Orthop Traumatol Surg Res，2023，109（8s）：103665.doi：10.1016/j.otsr.2023.103665http://dx.doi.org/10.1016/j.otsr.2023.103665.

张旭林，徐永清，何晓清，等.手舟骨骨内动脉的数字解剖学研究及其临床意义［J］.中国临床解剖学杂志，2020，38（3）：259-262.doi：10.13418/j.issn.1001-165x.2020.03.005http://dx.doi.org/10.13418/j.issn.1001-165x.2020.03.005.

Mercan N，Yıldırım A，Dere Y.Biomechanical analysis of tibiofibular syndesmosis injury fixation methods：a finite element analysis［J］.J Foot Ankle Surg，2023，62（1）：107-114.doi：10.1053/j.jfas.2022. 05.007http://dx.doi.org/10.1053/j.jfas.2022.05.007.

Ferguson DO，Shanbhag V，Hedley H，et al.Scaphoid fracture non-union：a systematic review of surgical treatment using bone graft［J］.J Hand Surg Eur Vol，2016，41（5）：492-500.doi：10.1177/1753193415 604778http://dx.doi.org/10.1177/1753193415604778.

刘卫华，唐曦，王智，等.Micro CT三维重建手舟骨相关显微影像解剖学数据测量［J］.中国组织工程研究，2014，18（22）：3537-3541.doi：10.3969/j.issn.2095-4344.2014.22.017http://dx.doi.org/10.3969/j.issn.2095-4344.2014.22.017.

Alshryda S，Shah A，Odak S，et al.Acute fractures of the scaphoid bone：systematic review and meta-analysis［J］.Surgeon，2012，10（4）：218-229.doi：10.1016/j.surge.2012.03.004http://dx.doi.org/10.1016/j.surge.2012.03.004.

Van Nest D，Ilyas AM.Scaphoid nonunion：a review of surgical strategies［J］.Orthopedics，2022，45（5）：e235-e242.doi：10.3928/01477447-20220608-03http://dx.doi.org/10.3928/01477447-20220608-03.

Yang Z，Wang C，Gao H，et al.Biomechanical effects of 3D-printed bioceramic scaffolds with porous gradient structures on the regeneration of alveolar bone defect：a comprehensive study［J］. Front Bioeng Biotechnol，2022，10：882631.doi：10.3389/fbioe.2022. 882631http://dx.doi.org/10.3389/fbioe.2022.882631.

Gire JD，Thio T，Behn AW，et al.Rotational stability of scaphoid waist nonunion bone graft and fixation techniques［J］.J Hand Surg Am，2020，45（9）：841-849.e1.doi：10.1016/j.jhsa.2020.05.012http://dx.doi.org/10.1016/j.jhsa.2020.05.012.

Yan M，Liang T，Zhao H，et al.Model properties and clinical application in the finite element analysis of knee joint：a review［J］.Orthop Surg，2024，16（2）：289-302.doi：10.1111/os.13980http://dx.doi.org/10.1111/os.13980.

Li B，Wen J，Liu H，et al.Dysplasia epiphysealis hemimelica combined with contralateral accessory scaphoid bone：a case report and literature review［J］.Medicine （Baltimore），2019，98（45）：e17887.doi：10.1097/MD.0000000000017887http://dx.doi.org/10.1097/MD.0000000000017887.

De Cet A，D'andrea L，Gastaldi D，et al.micro-CT imaging and finite element models reveal how sintering temperature affects the microstructure and strength of bioactive glass-derived scaffolds［J］.Sci Rep，2024，14（1）：969.doi：10.1038/s41598-023-50255-5http://dx.doi.org/10.1038/s41598-023-50255-5.

Norman DG，Baier W，Watson DG，et al.micro-CT for saw mark analysis on human bone［J］.Forensic Sci Int，2018，293：91-100.doi：10.1016/j.forsciint.2018.10.027http://dx.doi.org/10.1016/j.forsciint.2018.10.027.

Li Z，Shi D，Li H，et al.micro-CT study of the human cochlear aqueduct［J］.Surg Radiol Anat，2018，40（6）：713-720.doi：10.1007/s00276-018-2020-6http://dx.doi.org/10.1007/s00276-018-2020-6.

Cao H，Wu H，Li J，et al.Influence of different postballoon expansion procedures：a finite element analysis［J］.Med Phys，2023，50（1）：30-37.doi：10.1002/mp.16086http://dx.doi.org/10.1002/mp.16086.

Maitirouzi J，Luo H，Zhou Z，et al.Finite element analysis of human lumbar vertebrae in internal fixation system model with different bone density trajectories［J］.Int J Artif Organs，2022，45（5）：478-487.doi：10.1177/03913988221088613http://dx.doi.org/10.1177/03913988221088613.

Wang YG，Zhu GY，Liu JQ，et al.Dynamic biomechanical changes of clear aligners during extraction space closure：finite element analysis［J］.Am J Orthod Dentofacial Orthop，2024，165（3）：272-284.e3.doi：10.1016/j.ajodo.2023.08.017http://dx.doi.org/10.1016/j.ajodo.2023.08.017.

Kahaer A，Zhang R，Wang Y，et al.Hybrid pedicle screw and modified cortical bone trajectory technique in transforaminal lumbar interbody fusion at L4-L5 segment：finite element analysis［J］.BMC Musculoskelet Disord，2023，24（1）：288.doi：10.1186/s12891-023-06385-yhttp://dx.doi.org/10.1186/s12891-023-06385-y.

Ghargozloo D，Tomarchio A，Ballerini M，et al.Traumatic bilateral scaphoid fractures［J］.Med Glas （Zenica），2021，18（1）：222-225.doi：10.17392/1332-21http://dx.doi.org/10.17392/1332-21.

Ecker J.Scaphoid union：the role of wrist arthroscopy［J］.Hand Clin，2017，33（4）：677-686.doi：10.1016/j.hcl.2017.07.001http://dx.doi.org/10.1016/j.hcl.2017.07.001.

Feng C，Wang L，Xu P，et al.Microstructural and mechanical evaluations of region segmentation methods in classifications of osteonecrosis［J］.J Biomech，2021，119：110208.doi：10.1016/j.jbiomech.2020.110208http://dx.doi.org/10.1016/j.jbiomech.2020.110208.

Clark DM，Piscoya AS，Dunn JC，et al.Bone morphogenic protein-2 use for the surgical treatment of acute scaphoid fractures and scaphoid nonunions［J］.Plast Reconstr Surg，2022，150（3）：608e-612e.doi：10.1097/PRS.0000000000009416http://dx.doi.org/10.1097/PRS.0000000000009416.

Ek ET，Johnson PR，Bohan CM，et al.Autologous bone grafting and double screw fixation for unstable scaphoid nonunions with cavitary bone loss［J］.J Hand Surg Eur Vol，2021，46（2）：205-206.doi：10.1177/1753193420946656http://dx.doi.org/10.1177/1753193420946656.

吕利军，彭伟，常艳艳，等.腕关节镜辅助治疗手舟骨骨不连的治疗进展［J］.临床与病理杂志，2022，42（11）：2843-2849.doi：10.3978/j.issn.2095-6959.2022.11.037http://dx.doi.org/10.3978/j.issn.2095-6959.2022.11.037.

Boe CC，Amadio PC，Kakar S.The management of the healed scaphoid malunion：what to do？［J］.Hand Clin，2019，35（3）：373-379.doi：10.1016/j.hcl.2019.03.008http://dx.doi.org/10.1016/j.hcl.2019.03.008.

Janowski J，Coady C，3rdCatalano LW.Scaphoid fractures：nonunion and malunion［J］.J Hand Surg Am，2016，41（11）：1087-1092.doi：10.1016/j.jhsa.2016.08.019http://dx.doi.org/10.1016/j.jhsa.2016.08.019.

Ohs N，Collins CJ，Atkins PR.Validation of HR-pQCT against micro-CT for morphometric and biomechanical analyses：a review［J］.Bone Rep，2020，13：100711.doi：10.1016/j.bonr.2020.100711http://dx.doi.org/10.1016/j.bonr.2020.100711.

Kılıç B，Çalışkan M，Agar A，et al.Comparison of two different screw trajectories in the treatment of oblique scaphoid fractures：a mechanical study on composite bone models［J］.Jt Dis Relat Surg，2021，32（2）：377-382.doi：10.52312/jdrs.2021.15http://dx.doi.org/10.52312/jdrs.2021.15.

Schmidle G，Ebner HL，Klima G，et al.Time-dependent changes in bone healing capacity of scaphoid fractures and non-unions［J］.J Anat，2018，232（6）：908-918.doi：10.1111/joa.12795http://dx.doi.org/10.1111/joa.12795.

Ko JH，Pet MA，Khouri JS，et al.Management of scaphoid fractures［J］.Plast Reconstr Surg，2017，140（2）：333e-346e.doi：10.1016/j.hcl.2019.03.002http://dx.doi.org/10.1016/j.hcl.2019.03.002.

Tian A，Zhong Z，Li Y，et al.Biomechanical role of trabecular microstructure on peri-implant strain based on micro-CT finite element modeling of aging mice［J］.Int J Oral Maxillofac Implants，2021，36（4）：715-722.doi：10.11607/jomi.8611http://dx.doi.org/10.11607/jomi.8611.

Oka K，Murase T，Moritomo H，et al.Patterns of bone defect in scaphoid nonunion：a 3-dimensional and quantitative analysis［J］.J Hand Surg Am，2005，30（2）：359-365.doi：10.1016/j.jhsa.2004.10.004http://dx.doi.org/10.1016/j.jhsa.2004.10.004.

Wu T，Bonnheim NB，Pendleton MM，et al.Radiation-induced changes in load-sharing and structure-function behavior in murine lumbar vertebrae［J］.Comput Methods Biomech Biomed Engin，2023：1-9.doi：10.1080/10255842.2023.2239415http://dx.doi.org/10.1080/10255842.2023.2239415.

Peyrin F.Evaluation of bone scaffolds by micro-CT［J］.Osteoporos Int，2011，22（6）：2043-2048.doi：10.1007/s00198-011-1609-yhttp://dx.doi.org/10.1007/s00198-011-1609-y.

Pumberger M，Issever AS，Diekhoff T，et al.Bone structure determined by HR-MDCT does not correlate with micro-CT of lumbar vertebral biopsies：a prospective cross-sectional human in vivo study［J］.J Orthop Surg Res，2020，15（1）：398.doi：10.1186/s13018-020-01895-0http://dx.doi.org/10.1186/s13018-020-01895-0.

Ibrahim N，Parsa A，Hassan B，et al.Comparison of anterior and posterior trabecular bone microstructure of human mandible using cone-beam CT and micro CT［J］.BMC Oral Health，2021，21（1）：249.doi：10.1186/s12903-021-01595-zhttp://dx.doi.org/10.1186/s12903-021-01595-z.

Huang H，Chen D，Lippuner K，et al.Human bone typing using quantitative cone-beam computed tomography［J］.Int Dent J，2023，73（2）：259-266.doi：10.1016/j.identj.2022.08.011http://dx.doi.org/10.1016/j.identj.2022.08.011.

Guha I，Zhang X，Rajapakse CS，et al.Finite element analysis of trabecular bone microstructure using CT imaging and continuum mechanical modeling［J］.Med Phys，2022，49（6）：3886-3899.doi：10.1002/mp.15629http://dx.doi.org/10.1002/mp.15629.

Acar B，Köse Ö，Turan A，et al.Single versus double screw fixation for the treatment of scaphoid waist fractures：finite element analysis and preliminary clinical results in scaphoid nonunion［J］.Jt Dis Relat Surg，2020，31（1）：73-80.doi：10.5606/ehc.2020.71521http://dx.doi.org/10.5606/ehc.2020.71521.

Franceskide SC，Gibson M，Zioupos P.Evaluation of bone excision effects on a human skull model-Ⅱ：finite element analysis［J］.Proc Inst Mech Eng H，2020，234（4）：346-355.doi：10.1177/0954411 919892799http://dx.doi.org/10.1177/0954411919892799.

Campbell GM，Glüer CC.Skeletal assessment with finite element analysis：relevance，pitfalls and interpretation［J］.Curr Opin Rheumatol，2017，29（4）：402-409.doi：10.1097/BOR.000000000 0000405http://dx.doi.org/10.1097/BOR.0000000000000405.

Arab AZE，Merdji A，Benaissa A，et al.Finite-element analysis of a lateral femoro-tibial impact on the total knee arthroplasty［J］.Comput Methods Programs Biomed，2020，192：105446.doi：10.1016/j.cmpb.2020.105446http://dx.doi.org/10.1016/j.cmpb.2020.105446.

Carpenter RD.Finite element analysis of the hip and spine based on quantitative computed tomography［J］.Curr Osteoporos Rep，2013，11（2）：156-162.doi：10.1007/s11914-013-0141-8http://dx.doi.org/10.1007/s11914-013-0141-8.

Oláh T，Cai X，Gao L，et al.Quantifying the human subchondral trabecular bone microstructure in osteoarthritis with clinical CT［J］.Adv Sci （Weinh），2022，9（23）：e2201692.doi：10.1002/advs. 202201692http://dx.doi.org/10.1002/advs.202201692.

Sosa EM，Moure MM.Simulation of low-energy impacts on the human hand for prediction of peak reaction forces and bone fracture［J］.J Biomech，2023，160：111813.doi：10.1016/j.jbiomech.2023. 111813http://dx.doi.org/10.1016/j.jbiomech.2023.111813.

Santoshi JA，Behera P，Dwivedi RK，et al.Mechanism of scaphoid waist fracture：finite element analysis［J］.J Hand Surg Eur Vol，2023，48（5）：426-434.doi：10.1177/17531934221145516http://dx.doi.org/10.1177/17531934221145516.

张必欢，蔡兴博，王斌，等.个性化3D打印钛合金舟骨部分置换术后有限元模型的建立及生物力学分析［J］.中国临床解剖学杂志，2024，42（3）：293-303.doi：10.13418/j.issn.1001-165x. 2024.3.09http://dx.doi.org/10.13418/j.issn.1001-165x.2024.3.09.

Kusins J，Knowles N，Martensson N，et al.Full-field experimental analysis of the influence of microstructural parameters on the mechanical properties of humeral head trabecular bone［J］.J Orthop Res，2022，40（9）：2048-2056.doi：10.1002/jor.25242http://dx.doi.org/10.1002/jor.25242.

Dong M，Kerkhof F，Deleu G，et al.Using a finite element model of the thumb to study trapeziometacarpal joint contact during lateral pinch［J］.Clin Biomech （Bristol，Avon），2023，101：105852.doi：10.1016/j.clinbiomech.2022.105852http://dx.doi.org/10.1016/j.clinbiomech.2022.105852.

Guha I，Zhang X，Nadeem SA，et al.Continuum finite element analysis generalizesin vivotrabecular bone microstructural strength measures between two CT scanners with different image resolution［J］.Biomed Phys Eng Express，2023，9（2）：25012.doi：10.1088/2057-1976/acbb0ahttp://dx.doi.org/10.1088/2057-1976/acbb0a.

Varga P，Zysset PK，Schefzig P，et al.A finite element analysis of two novel screw designs for scaphoid waist fractures［J］.Med Eng Phys，2016，38（2）：131-139.doi：10.1016/j.medengphy.2015.11.006http://dx.doi.org/10.1016/j.medengphy.2015.11.006.

Doi K，Oda T，Soo-Heong T，et al.Free vascularized bone graft for nonunion of the scaphoid［J］.J Hand Surg Am，2000，25（3）：507-519.doi：10.1053/jhsu.2000.5993http://dx.doi.org/10.1053/jhsu.2000.5993.

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