Application of ropivacaine combined with dezocine in painless delivery of primiparas with epidural anesthesia

YANG Dong-dong; GONG Xiao-yi; LING Yun-zhi; WANG Ya-xiang; SUN Mei; DUAN Rui; YE Xia; ZHANG Ya

doi:10.11659/jjssx.07E024119

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Application of ropivacaine combined with dezocine in painless delivery of primiparas with epidural anesthesia

Clinical Research | 更新时间：2025-06-17

- Application of ropivacaine combined with dezocine in painless delivery of primiparas with epidural anesthesia
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 6, Pages: 535-539(2025)
- 作者机构：
  
  1.南京江北医院麻醉科，江苏南京 210044
  2.蚌埠医科大学第一附属医院麻醉科，安徽蚌埠 233004
  3.南京江北医院妇产科，江苏南京 210044
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.07E024119
  CLC： R246.3
- Received：23 July 2024，
  
  Published：25 June 2025
- 稿件说明：
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杨栋栋,龚晓毅,凌云志等.罗哌卡因联合地佐辛在硬膜外麻醉初产妇无痛分娩中的应用[J].局解手术学杂志,2025,34(06):535-539.

YANG Dong-dong,GONG Xiao-yi,LING Yun-zhi,et al.Application of ropivacaine combined with dezocine in painless delivery of primiparas with epidural anesthesia[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(06):535-539.
杨栋栋,龚晓毅,凌云志等.罗哌卡因联合地佐辛在硬膜外麻醉初产妇无痛分娩中的应用[J].局解手术学杂志,2025,34(06):535-539. DOI： 10.11659/jjssx.07E024119.

YANG Dong-dong,GONG Xiao-yi,LING Yun-zhi,et al.Application of ropivacaine combined with dezocine in painless delivery of primiparas with epidural anesthesia[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(06):535-539. DOI： 10.11659/jjssx.07E024119.

摘要

目的

探究罗哌卡因与地佐辛联合硬膜外麻醉对无痛分娩初产妇下肢运动神经阻滞效果及母婴结局的影响。

方法

选取在南京江北医院进行分娩的初产妇159例为研究对象，采用随机数字表法分为空白组（53例）、罗哌卡因组（53例）和联合组（53例）。其中空白组产妇采用自然分娩方式，罗哌卡因组产妇采用罗哌卡因硬膜外麻醉，联合组产妇在应用罗哌卡因的基础上加用地佐辛麻醉。比较3组产妇不同时点镇痛效果，第一、二、三产程时间及镇痛泵按压次数，下肢运动神经阻滞情况，母婴结局及不良反应发生情况。

结果

镇痛后10 min、镇痛后60 min、宫口全开时和胎儿娩出时，罗哌卡因组和联合组产妇VAS评分均低于空白组（

0.05），联合组产妇VAS评分均显著低于罗哌卡因组（

0.05）。3组产妇第一、二、三产程时间比较，差异均无统计学意义（

0.05）；联合组产妇镇痛泵按压次数显著少于罗哌卡因组（

0.05）。无痛分娩后，3组产妇下肢运动神经阻滞情况比较，差异均无统计学意义（

0.05）。3组产妇会阴切开率及新生儿出生后1 min、5 min的Apgar评分比较，差异均无统计学意义（

0.05）；联合组产妇产钳使用率、转剖宫产率显著低于罗哌卡因组和空白组（

0.05）。空白组、罗哌卡因组与联合组产妇的总不良反应发生率比较，差异无统计学意义（

0.05）。

结论

罗哌卡因与地佐辛联合硬膜外麻醉对无痛分娩初产妇镇痛效果较好，对产妇下肢运动神经阻滞影响较小，可获得较好的母婴结局。

Abstract

Objective

To investigate the impacts of epidural anesthesia with ropivacaine combined with dezocine on lower limb motor nerve block and maternal and infant outcomes in primipara undergoing painless delivery.

Methods

A total of 159 primiparas who delivered in Nanjing Jiangbei Hospital were selected as the research objects，and divided into the blank group （53 cases），the ropivacaine group （53 cases） and the combined group （53 cases） by the random number table method. Parturients in the blank group were given natural delivery mode，parturients in the ropivacaine group were given ropivacaine epidural anesthesia，and parturients in the combined group were given dezocine anesthesia on the basis of ropivacaine. Analgesic effect at different time points，time of the first，second and third stage of labor，pressing times of analgesic pump，lower limbs motor nerve block，maternal and infant outcomes，and adverse reactions of parturients were compared among the three groups.

Results

At 10 minutes after analgesia，60 minutes after analgesia，when the cervix was fully dilated and when the fetus was delivered，the VAS scores of the parturients in the ropivacaine group and the combined group were lower than those in the blank group （

0.05），and the VAS scores of the parturients in the combined group were significantly lower than those in the ropivacaine group （

0.05）. There was no significant difference in the time of the first，second or third stage of labor of parturients among the three groups（

0.05）； The pressing times of analgesic pump of parturients in the combined group was significantly less than that in the ropivacaine group（

0.05）. There was no statistically significant difference in terms of low limb motor nerve block after painless labor of parturients among the three groups（

0.05）. There were no statistically significant differences in the perineal incision rate or the Apgar scores of newborns at 1 minute and 5 minutes after birth among the three groups （

0.05）. The usage rate of forceps and the rate of conversion to cesarean section in the combined group were significantly lower than those in the ropivacaine group and the blank group （

0.05）. There was no statistically significant difference in the incidence of total adverse reactions among the blank group，the ropivacaine group and the combined group （

0.05）.

Conclusion

The combination of ropivacaine and dezocine for epidural anesthesia has a better analgesic effect on primiparas with painless delivery，has a smaller impact on lower limb motor nerve block in parturients，and can achieve better maternal and infant outcomes.

关键词

Keywords

references

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