Correlation of the expression of ILT4 and CD147 with tumor immunoinfiltration and prognosis in lung adenocarcinoma

LI Jia-hui; GUO Yi-ze; HU Wen; ZHANG Li

doi:10.11659/jjssx.06E025130

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Correlation of the expression of ILT4 and CD147 with tumor immunoinfiltration and prognosis in lung adenocarcinoma

Clinical Research | 更新时间：2025-11-25

- Correlation of the expression of ILT4 and CD147 with tumor immunoinfiltration and prognosis in lung adenocarcinoma
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 11, Pages: 993-997(2025)
- 作者机构：
  
  1.空军军医大学唐都医院肿瘤科，陕西西安 710038
  2.空军军医大学唐都医院胸外科，陕西西安 710038
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.06E025130
  CLC： R734.2
- Received：25 June 2025，
  
  Published：25 November 2025
- 稿件说明：
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李佳慧,郭一泽,胡雯等.肺腺癌中ILT4、CD147表达与肿瘤免疫浸润及预后的相关性研究[J].局解手术学杂志,2025,34(11):993-997.

LI Jia-hui,GUO Yi-ze,HU Wen,et al.Correlation of the expression of ILT4 and CD147 with tumor immunoinfiltration and prognosis in lung adenocarcinoma[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(11):993-997.
李佳慧,郭一泽,胡雯等.肺腺癌中ILT4、CD147表达与肿瘤免疫浸润及预后的相关性研究[J].局解手术学杂志,2025,34(11):993-997. DOI： 10.11659/jjssx.06E025130.

LI Jia-hui,GUO Yi-ze,HU Wen,et al.Correlation of the expression of ILT4 and CD147 with tumor immunoinfiltration and prognosis in lung adenocarcinoma[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(11):993-997. DOI： 10.11659/jjssx.06E025130.

摘要

目的

分析ILT4、CD147在肺腺癌中的表达及其与肿瘤免疫浸润和患者预后的关系。

方法

收集2024年1－12月在我院接受手术治疗的134例肺腺癌患者的癌组织和癌旁组织标本，并对患者临床资料进行回顾性分析。采用免疫组化法和qRT-PCR分别检测不同组织中ILT4、CD147的蛋白及mRNA表达；分析ILT4、CD147表达与肺腺癌临床病理特征的相关性。基于GEPIA2数据库检索ILT4、CD147在泛癌组织中的表达，并分析其与肺腺癌预后的关系。基于TIMER数据库分析肺腺癌样本中ILT4、CD147表达与6种免疫细胞浸润的相关性。

结果

肺腺癌组织中ILT4和CD147蛋白阳性率及mRNA表达水平均明显高于癌旁组织（

0.05）。GEPIA数据库分析显示，ILT4、CD147在多种肿瘤中表达上调，肺腺癌组织中ILT4、CD147表达水平均高于非配对的癌旁组织。ILT4蛋白表达与肺腺癌TNM分期、淋巴结转移密切相关（

0.05）；CD147蛋白表达与TNM分期、淋巴结转移及分化程度相关（

0.05）。GEPIA数据库分析显示，ILT4和CD147高表达患者总生存率低于低表达患者（

Log

rank P

=0.000 58、0.002 6）。TIMER数据库分析显示，ILT4表达与巨噬细胞、中性粒细胞和树突状细胞浸润呈明显负相关（

0.05）；CD147表达与B细胞、CD4

T细胞和树突状细胞浸润呈明显负相关（

0.05）。

结论

肺腺癌组织中ILT4、CD147均高表达，二者与患者临床病理特征、预后及免疫浸润相关，可能是肺腺癌患者预后评估的潜在标志物及免疫治疗靶点。

Abstract

Objective

To analyze the expression of ILT4 and CD147 in lung adenocarcinoma and their relationships with tumor immunoinfiltration and prognosis of patients.

Methods

The specimens of cancer tissues and adjacent tissues of 134 patients with lung adenocarcinoma who underwent surgical treatment at our hospital from January to December 2024 were collected， and a retrospective analysis was conducted on the clinical data of the patients. The protein and mRNA expression of ILT4 and CD147 in different tissues were detected by immunohistochemistry and qRT-PCR， respectively. The correlations of the expression of ILT4 and CD147 with the clinicopathological characteristics of lung adenocarcinoma were analyzed. The expression of ILT4 and CD147 in pan-cancer tissues were retrieved based on the GEPIA2 database，and their relationships with the prognosis of lung adenocarcinoma were analyzed. The correlations of the expression of ILT4 and CD147 with the infiltration of 6 kinds of immune cells in lung adenocarcinoma samples were analyzed based on TIMER database.

Results

The protein positive rates and mRNA expression levels of ILT4 and CD147 in lung adenocarcinoma tissues were significantly higher than those in adjacent tissues （

0.05）. The analysis of GEPIA database showed that ILT4 and CD147 upregulated in various tumors， and the expression levels of ILT4 and CD147 in lung adenocarcinoma tissues were both higher than those in unpaired adjacent tissues. The expression of ILT4 protein was closely related to the TNM stage and lymph node metastasis of lung adenocarcinoma （

0.05）；the expression of CD147 protein was correlated with TNM stage，lymph node metastasis and degree of differentiation （

0.05）. The analysis of GEPIA database showed that the patients with high expression of ILT4 and CD147 had lower overall survival rates than those with low expression（

Log-rank

=0.000 58，0.002 6）. The analysis of the TIMER database showed that the expression of ILT4 was negatively correlated with the infiltration of macrophages，neutrophils and dendrit

ic cells （

0.05）；the expression of CD147 was negatively correlated with the infiltration of B cells，CD4

T cells and dendritic cells （

0.05）.

Conclusion

ILT4 and CD147 are highly expressed in lung adenocarcinoma tissues，which are related to clinicopathological features，prognosis and immunoinfiltration of patients. They may be the potential markers for prognosis evaluation and immunotherapeutic targets of patients with lung adenocarcinoma.

关键词

Keywords

references

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