Expression of NUDT5 in breast cancer and its correlation with ultrasound signs and clinicopathological characteristics

RONG Lu; ZHOU Min; YU Lu-xin; LYU Juan; WAN Jing; ZHANG Qian

doi:10.11659/jjssx.06E024125

您当前的位置：

首页 >

文章列表页 >

Expression of NUDT5 in breast cancer and its correlation with ultrasound signs and clinicopathological characteristics

Clinical Research | 更新时间：2025-05-26

- Expression of NUDT5 in breast cancer and its correlation with ultrasound signs and clinicopathological characteristics
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 5, Pages: 421-424(2025)
- 作者机构：
  
  1.新疆维吾尔自治区人民医院超声科，新疆乌鲁木齐 830002
  2.新疆维吾尔自治区人民医院乳甲外科，新疆乌鲁木齐 830002
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.06E024125
  CLC： R737.9
- Received：28 June 2024，
  
  Published：25 May 2025
- 稿件说明：
移动端阅览
荣鹿,周敏,于鲁欣等.乳腺癌组织中NUDT5表达及其与超声征象和临床病理特征的相关性[J].局解手术学杂志,2025,34(05):421-424.

RONG Lu,ZHOU Min,YU Lu-xin,et al.Expression of NUDT5 in breast cancer and its correlation with ultrasound signs and clinicopathological characteristics[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(05):421-424.
荣鹿,周敏,于鲁欣等.乳腺癌组织中NUDT5表达及其与超声征象和临床病理特征的相关性[J].局解手术学杂志,2025,34(05):421-424. DOI： 10.11659/jjssx.06E024125.

RONG Lu,ZHOU Min,YU Lu-xin,et al.Expression of NUDT5 in breast cancer and its correlation with ultrasound signs and clinicopathological characteristics[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(05):421-424. DOI： 10.11659/jjssx.06E024125.

摘要

目的

探讨乳腺癌组织中Nudix结构水解酶5（NUDT5）蛋白表达及其与超声征象和临床病理特征的相关性。

方法

选取2019年10月至2022年4月本院收治的乳腺癌患者108例为研究对象。术前进行超声检查，观察患者影像学征象。采用免疫组化法检测乳腺癌组织中雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（HER-2）表达及乳腺癌组织及癌旁组织中NUDT5蛋白表达水平，并分析NUDT5蛋白表达与患者超声征象及临床病理特征的关系。

结果

108例患者中，ER阳性62例，PR阳性60例，HER-2阳性28例。NUDT5蛋白在乳腺癌组织中的阳性表达率高于癌旁组织（

0.05）。NUDT5蛋白在微小钙化、血流显像分级（2~3级）、淋巴结转移的乳腺癌组织中阳性表达率更高（

0.05）。NUDT5蛋白阳性表达与患者组织学分级、ER、HER-2相关（

0.05）。乳腺癌组织中NUDT5蛋白

表达与ER阴性、HER-2阳性呈正相关（

=0.463、0.398，

0.05）。

结论

乳腺癌组织中NUDT5蛋白阳性表达率高于癌旁组织，其表达与超声征象中的微小钙化、血流显像分级（2~3级）、淋巴结转移及临床病理特征中的组织学分级、ER、HER-2具有一定的相关性。

Abstract

Objective

To explore the expression of Nudix hydrolase 5 （NUDT5） protein in breast cancer tissues and its correlation with ultrasound signs and clinicopathological characteristics.

Methods

A total of 108 patients with breast cancer admitted to our hospital from October 2019 to April 2022 were selected as the research objects. Ultrasound examination was performed before operation to observe the ultrasound signs of patients. Immunohistochemical method was used to detect the expressions of estrogen receptor （ER）， progesterone receptor （PR） and human epidermal growth factor receptor 2 （HER-2） in breast cancer tissues， and the expression levels of NUDT5 protein in breast cancer tissues and adjacent tissues， and the relationships of NUDT5 protein expression with ultrasound signs and clinicopathological characteristics of patients were analyzed.

Results

Among 108 patients， there were 62 cases with ER positive， 60 cases with PR positive， and 28 cases with HER-2 positive.The positive expression rate of NUDT5 protein in breast cancer tissues was higher than that in adjacent tissues （

0.05）. The positive expression rate of NUDT5 protein was higher in breast cancer tissues with microcalcification， blood flow imaging grade （grade 2 to 3） and lymph node metastasis （

0.05）. The positive expression of NUDT5 protein was correlated with histological grade， ER and HER-2 （

0.05）. The expression of NUDT5 protein in breast cancer tissue was positively correlated with ER negative and HER-2 positive （

=0.463， 0.398，

0.05）.

Conclusion

The positive expression rate of NUDT5 protein in breast cancer tissues is higher than that in adjacent tissues， and its expression has a certain correlation with microcalcification， blood flow imaging grade （grade 2 to 3），lymph node metastasis in ultrasound signs and histological grade，ER，and HER-2 in clinicopathological characteristics.

关键词

Keywords

references

Sung H ， Ferlay J ， Siegel RL ， et al . Global Cancer Statistics 2020：GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries ［J］. CA Cancer J Clin ， 2021 ， 71 （ 3 ）： 209 - 249 . doi： 10.3322/caac.21660 http://dx.doi.org/10.3322/caac.21660 .

Li H ， Cheng C ， Wang Y ， et al . Combined diagnosis of ultrasonic elastography and BI-RADS classification increases diagnostic value in female patients with breast neoplasms ［J］. Am J Transl Res ， 2021 ， 13 （ 10 ）： 11758 - 11763 .

代新珍，米贤军，钟守军，等 . 浸润性乳腺癌中FosB的表达与超声征象及临床病理的相关性［J］. 中山大学学报（医学科学版）， 2020 ， 41 （ 1 ）： 135 - 142 . doi： 10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2020.0019 http://dx.doi.org/10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2020.0019 .

张爱红，赵晓欢，申国升 . 乳腺癌超声征象与CRP、VEGF-C、CD34表达的相关性研究［J］. 医学综述， 2021 ， 27 （ 9 ）： 1863 - 1867 . doi： 10.3969/j.issn.1006-2084.2021.09.036 http://dx.doi.org/10.3969/j.issn.1006-2084.2021.09.036 .

Pickup KE ， Pardow F ， Carbonell-Caballero J ， et al . Expression of oncogenic drivers in 3D cell culture depends on nuclear ATP synthesis by NUDT5 ［J］. Cancers （Basel）， 2019 ， 11 （ 9 ）： 1337 . doi： 10.3390/cancers11091337 http://dx.doi.org/10.3390/cancers11091337 .

Zhang H ， Zhang LQ ， Yang CC ， et al . The high expression of NUDT5 indicates poor prognosis of breast cancer by modulating AKT/Cyclin D signaling ［J］. PLoS One ， 2021 ， 16 （ 2 ）： e0245876 . doi： 10.1371/journal.pone.0245876 http://dx.doi.org/10.1371/journal.pone.0245876 .

赵临潇，左博云，黄娟娟，等 . 葡萄糖转运蛋白-1、p53蛋白在乳腺癌癌组织中的表达及其与临床病理特征和预后的相关性［J］. 海南医学， 2021 ， 32 （ 18 ）： 2323 - 2326 . doi： 10.3969/j.issn.1003-6350. 2021.18.003 http://dx.doi.org/10.3969/j.issn.1003-6350.2021.18.003 .

Cao W ， Chen HD ， Yu Y ， et al . Changing profiles of cancer burden worldwide and in China：a secondary analysis of the global cancer statistics 2020 ［J］. Chin Med J （Engl）， 2021 ， 134 （ 7 ）： 783 - 791 . doi： 10.1097/CM9.0000000000001474 http://dx.doi.org/10.1097/CM9.0000000000001474 .

Thakur C ， Qiu Y ， Pawar A ， et al . Epigenetic regulation of breast cancer metastasis ［J］. Cancer Metastasis Rev ， 2024 ， 43 （ 2 ）： 597 - 619 . doi： 10.1007/s10555-023-10146-7 http://dx.doi.org/10.1007/s10555-023-10146-7 .

Piatkowski AA ， Wederfoort JLM ， Hommes JE ， et al . Effect of total breast reconstruction with autologous fat transfer using an expansion device vs implants on quality of life among patients with breast cancer：a randomized clinical trial ［J］. JAMA Surg ， 2023 ， 158 （ 5 ）： 456 - 464 . doi： 10.1001/jamasurg.2022.7625 http://dx.doi.org/10.1001/jamasurg.2022.7625 .

Early Breast Cancer Trialists' Collaborative Group （EBCTCG） . Anthracycline-containing and taxane-containing chemotherapy for early-stage operable breast cancer：a patient-level meta-analysis of 100 000 women from 86 randomised trials ［J］. Lancet ， 2023 ， 401 （ 10384 ）： 1277 - 1292 . doi： 10.1016/S0140-6736（23）00285-4 http://dx.doi.org/10.1016/S0140-6736（23）00285-4 .

黄锦源，杨静，代荫梅 . lncRNA UCA1在乳腺癌发病中的作用机制及其临床应用研究进展［J］. 山东医药， 2022 ， 62 （ 20 ）： 112 - 115 . doi： 10.3969/j.issn.1002-266X.2022.20.028 http://dx.doi.org/10.3969/j.issn.1002-266X.2022.20.028 .

黄贵廉，陈智毅 . 乳腺癌超声征象与分子标志物的相关性研究进展［J］. 中国医学影像学杂志， 2021 ， 29 （ 1 ）： 86 - 88 . doi： 10.3969/j.issn.1005-5185.2021.01.022 http://dx.doi.org/10.3969/j.issn.1005-5185.2021.01.022 .

Wang JJ ， Liu TH ， Li J ， et al . The high expression of MTH1 and NUDT5 predict a poor survival and are associated with malignancy of esophageal squamous cell carcinoma ［J］. Peer J ， 2020 ， 8 （ 1 ）： e9195 . doi： 10.7717/peerj.9195 http://dx.doi.org/10.7717/peerj.9195 .

郁玮玮，郭艳梅，严俊，等 . NUDT5蛋白表达在食管鳞癌组织中的表达及意义［J］. 中华转移性肿瘤杂志， 2018 ， 1 （ 1 ）： 37 - 42 . doi： 10.3760/cma.j.issn.2096-5400.2018.01.009 http://dx.doi.org/10.3760/cma.j.issn.2096-5400.2018.01.009 .

Wright RHG ， Lioutas A ， Le Dily F ， et al . ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling ［J］. Science ， 2016 ， 352 （ 6290 ）： 1221 - 1225 . doi： 10.1126/science.aad 9335 http://dx.doi.org/10.1126/science.aad9335 .

Page BDG ， Valerie NCK ， Wright RHG ， et al . Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells ［J］. Nat Commun ， 2018 ， 9 （ 1 ）： 250 - 263 . doi： 10.1038/s41467-017-02293-7 http://dx.doi.org/10.1038/s41467-017-02293-7 .

刘燕妮，金红艳，柳艳飞，等 . 浸润性乳腺癌病理分子表达联合超声征象的相关性研究［J］. 中国临床医生杂志， 2021 ， 49 （ 7 ）： 822 - 825 . doi： 10.3969/j.issn.2095-8552.2021.07.020 http://dx.doi.org/10.3969/j.issn.2095-8552.2021.07.020 .

薛林燕，赵旭，才让卓玛，等 . 乳腺癌患者ER、PR、C-erbB-2、Ki-67的表达与超声征象的关系［J］. 中国老年学杂志， 2018 ， 38 （ 7 ）： 1603 - 1605 . doi： 10.3969/j.issn.1005-9202.2018.07.030 http://dx.doi.org/10.3969/j.issn.1005-9202.2018.07.030 .

Liu J ， Huang L . Image-guided vacuum-assisted breast biopsy in the diagnosis of breast microcalcifications ［J］. J Int Med Res ， 2018 ， 46 （ 7 ）： 2743 - 2753 . doi： 10.1177/0300060518770577 http://dx.doi.org/10.1177/0300060518770577 .

周理好，李安洋，周理红，等 . miRNA-21-5p在乳腺癌组织中的表达及与超声征象的相关性［J］. 齐齐哈尔医学院学报， 2021 ， 42 （ 6 ）： 461 - 464 . doi： 10.3969/j.issn.1002-1256.2021.06.001 http://dx.doi.org/10.3969/j.issn.1002-1256.2021.06.001 .

涂金晶，张鑫，刘青 . 乳腺癌超声征象与P120ctn、Ki67表达水平的相关性［J］. 河北医科大学学报， 2017 ， 38 （ 3 ）： 316 - 320 . doi： 10.3969/j.issn.1007-3205.2017.03.017 http://dx.doi.org/10.3969/j.issn.1007-3205.2017.03.017 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mammographic imaging features of breast cancer and its correlation with microvascular density

Research progress of miR-192 in tumors

Correlation between changes of sagittal spinopelvic parameters after hip arthroplasty and facet joint-derived low back pain

Effects of CircNRIP1 on proliferation, apoptosis and chemotherapy resistance of breast cancer cells through regulating miR-136-5p/RAC1 axis

Differential expression and significance of serum miR-155 and miR-23b in idiopathic granulomatous mastitis and breast cancer

Related Author

MA Li-qin

LIU Li

HU Heng-li

CHEN Yu-lei

CHEN Long-zhou

HAN Zhi-gang

MO Ri-gen

YANG Ying-hai

Related Institution

Department of Radiology， Xinjiang Production and Construction Corps 7th Division Hospital， Yili Xinjiang

Department of Radiology， Huai'an Maternal and Child Health Care Hospital Affiliated to School of Medicine of Yangzhou University

Department of Gastrointestinal Surgery，Xilingol League Mongolian Medicine Hospital，Xilinhot Inner Mongolia

Department of Orthopedics， First Affiliated Hospital of Xi'an Jiaotong University

Department of Thyroid and Breast Surgery， Cangzhou People's Hospital

⁰