New progress in molecular diagnostic methods for early-onset sepsis in newborns

TAN Xiong-jun; LIN Ji-tao; ZHU Xiao-lian; ZHANG Li-juan; WEN Qing-hua; ZHENG Huai-wu

doi:10.11659/jjssx.06E024059

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New progress in molecular diagnostic methods for early-onset sepsis in newborns

Review | 更新时间：2025-01-16

- New progress in molecular diagnostic methods for early-onset sepsis in newborns
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 1, Pages: 89-92(2025)
- 作者机构：
  
  深圳市宝安区人民医院新生儿科，广东深圳 518101
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.06E024059
  CLC： R725.9
- Published：25 January 2025，
  
  Received：17 June 2024，
- 稿件说明：
移动端阅览
TAN XIONG-JUN, LIN JI-TAO, ZHU XIAO-LIAN, et al. New progress in molecular diagnostic methods for early-onset sepsis in newborns. [J]. Journal of regional anatomy and operative surgery, 2025, 34(1): 89-92.
DOI：

TAN XIONG-JUN, LIN JI-TAO, ZHU XIAO-LIAN, et al. New progress in molecular diagnostic methods for early-onset sepsis in newborns. [J]. Journal of regional anatomy and operative surgery, 2025, 34(1): 89-92. DOI： 10.11659/jjssx.06E024059.

摘要

新生儿败血症是一个全球性的健康问题，严重影响新生儿的身体健康及生命安全；在早产儿中，其发病率更高，尤其是出生后72 h内的早发性败血症（EOS）。新生儿EOS的诊断需进行一系列检查，早期和准确的诊断能够及时改善患儿临床结局并减少抗生素的过度使用。目前，EOS诊断的常用生物标志物和传统血培养方法具有一定缺点，因此寻找新的分子诊断方法迫在眉睫。本文总结并比较了新生儿EOS的早期与新型诊断方法，以期为临床提供参考。

Abstract

Neonatal sepsis is a global health problem that seriously affects the body health and life safety of newborns. It has a higher incidence in preterm infants， especially for early-onset sepsis （EOS） within 72 hours of birth.The diagnosis of neonatal EOS requires a series of examinations， and early and accurate diagnosis can improve clinical outcomes and reduce antibiotic overuse in a timely manner. At present， the commonly used biomarkers and traditional blood culture methods for EOS diagnosis have certain shortcomings， so it is urgent to find new molecular diagnostic methods. This article summarizes and compares the early and novel diagnostic methods of neonatal EOS， in order to provide a reference for clinical practice.

关键词

新生儿败血症新生儿早发性败血症PCR技术T2磁共振技术分子诊断方法

Keywords

neonatal sepsisneonatal early-onset sepsisPCR technologymagnetic resonance T2 techniquemolecular diagnostic methods

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