Comparative effectiveness of small optical zone orthokeratology lenses and repeated low-level red-light therapy for controlling myopia in adolescents

LIU Shi-mei; CHEN Li; LUO Da; LUO Qi-hui; CHENG Yu; TANG Ren-xiang; YANG Wei; LIU Bo

doi:10.11659/jjssx.04E025045

您当前的位置：

首页 >

文章列表页 >

Comparative effectiveness of small optical zone orthokeratology lenses and repeated low-level red-light therapy for controlling myopia in adolescents

Clinical Research | 更新时间：2025-11-25

- Comparative effectiveness of small optical zone orthokeratology lenses and repeated low-level red-light therapy for controlling myopia in adolescents
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 11, Pages: 972-976(2025)
- 作者机构：
  
  1.陆军军医大学第一附属医院眼科，重庆 400038
  2.千叶眼科医院，重庆 400039
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.04E025045
  CLC： R778.1+1
- Received：10 April 2025，
  
  Published：25 November 2025
- 稿件说明：
移动端阅览
刘世美,陈利,罗达等.小光学区角膜塑形镜与重复低强度红光照射对青少年近视控制效果的比较[J].局解手术学杂志,2025,34(11):972-976.

LIU Shi-mei,CHEN Li,LUO Da,et al.Comparative effectiveness of small optical zone orthokeratology lenses and repeated low-level red-light therapy for controlling myopia in adolescents[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(11):972-976.
刘世美,陈利,罗达等.小光学区角膜塑形镜与重复低强度红光照射对青少年近视控制效果的比较[J].局解手术学杂志,2025,34(11):972-976. DOI： 10.11659/jjssx.04E025045.

LIU Shi-mei,CHEN Li,LUO Da,et al.Comparative effectiveness of small optical zone orthokeratology lenses and repeated low-level red-light therapy for controlling myopia in adolescents[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(11):972-976. DOI： 10.11659/jjssx.04E025045.

摘要

目的

通过对比分析小光学区角膜塑形镜（OK镜）与重复低强度红光照射疗法（RLRL）对青少年近视的控制效果，以评估RLRL的治疗有效性。

方法

回顾性分析于陆军军医大学第一附属医院就诊的80例青少年近视患者的临床资料，根据不同干预方式分为RLRL组和OK镜组，每组40例。RLRL组患者采用RLRL联合单焦点框架眼镜治疗，OK镜组患者佩戴OK镜。观察患者基线及治疗后1、3、6、12个月等效球镜度数（SE）、眼轴、黄斑中心凹脉络膜厚度（SFCT）和色觉变化情况。以RLRL组基线眼轴均值为准，将该组患者细分为短眼轴组和长眼轴组，进一步分析眼轴及SFCT的变化。

结果

RLRL组患者治疗后1、3、6、12个月的屈光度与基线比较差异无统计学意义（

0.05）。RLRL组患者眼轴治疗后呈渐进性缩短，12个月时恢复接近基线；OK镜组患者眼轴治疗后12个月内持续增长；2组患者治疗后各时间点眼轴与基线比较，差异均有统计学意义（

0.05）。RLRL组患者治疗后各时间点的眼轴变量均明显小于OK镜组（

0.05）。RLRL组患者治疗后各时间点的SFCT变量均大于OK镜组（

0.05）；RLRL组患者治疗后各时间点SFCT与基线比较有显著性差异（

0.05），但OK镜组患者治疗后各时间点SFCT与基线相比则无显著性差异（

0.05）。长眼轴组患者治疗后各时间点的眼轴变量均大于短眼轴组（

0.05）；长眼轴组患者仅在治疗后6个月SFCT变量大于短眼轴组（

0.05）；2组患者治疗后各时间点的SFCT与基线比较均有显著性差异（

0.05）。色觉测试显示，RLRL组和OK镜组患者治疗后均未出现色觉异常。

结论

RLRL具有较好的近视防控效果，对眼轴的控制效果优于OK镜。

Abstract

Objective

To compare the effect of small optical zone orthokeratology lenses （OK lenses）and repeated low-level red-light （RLRL） therapy in controlling myopia progression for adolescents，and the therapeutic effectiveness of RLRL is evaluated.

Methods

A retrospective analysis was conducted on the clinical data of 80 adolescent myopic patients in the First Affiliated Hospital of Army Medical University.The patients were divided into the RLRL group and the OK lenses group according to different intervention methods， with 40 cases in each group.Patients in the RLRL group received RLRL therapy combined with single-vision spectacles，and patients in the OK lenses group were treated with OK lenses.The changes of spherical equivalent （SE）， axial length and subfoveal choroidal thickness （SFCT） 1， 3， 6， and 12 months after treatment compared with the baseline， and color vision of patients were assessed. Based on the mean baseline axial length of the RLRL group， the patients in this group were subdivided into the short axial group and the long axial group， and the changes of the axial length and SFCT were further analyzed.

Results

The diopter 1， 3， 6， and 12 months after treatment in the RLRL group were not significantly different from the baseline （

0.05）.Axial lengths of patients in the RLRL group progressively shortened after treatment and returned close to the baseline 12 months after treatment. In contrast，axial lengths of patients in the OK lens continued to grow within 12 months after treatment； the axial lengths at each time point after treatment of patients in the two groups were significantly different from the baseline （

0.05）. The changes of axial length of patients in the RLRL group at each time point after treatment were significantly smaller than those in the OK lenses group （

0.05）. The SFCT changes of patients in the RLRL group at each time point after treatment were all greater than those in the OK lenses group （

0.05）. The SFCT at each time point after treatment in the RLRL group were significantly different from the baseline （

0.05）， whereas the SFCT at each time point after treatment in the OK lenses group were not significantly different from the baseline （

0.05）. The changes of axial length at each time point after treatment of patients in the long axial group were all greater than those in the short axial group （

0.05）； the SFCT changes 6 months after treatment of patients in the long axial group was greater than that in the short axial group （

0.05）； the SFCT at each time point after treatment of patients in the two groups were significantly different from the baseline （

0.05）.Color vision tests r

evealed no abnormities after treatment in the RLRL group and the OK lenses group.

Conclusion

RLRL therapy is effective in controlling myopia progression and demonstrates superior axial length control compared to orthokeratology lenses.

关键词

Keywords

references

Holden BA ， Fricke TR ， Wilson DA ， et al . Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050 ［J］. Ophthalmology ， 2016 ， 123 （ 5 ）： 1036 - 1042 . doi： 10.1016/j.ophtha.2016.01.006 http://dx.doi.org/10.1016/j.ophtha.2016.01.006 .

Kaiti R ， Shyangbo R ， Sharma IP ， et al . Review on current concepts of myopia and its control strategies ［J］. Int J Ophthalmol ， 2021 ， 14 （ 4 ）： 606 - 615 . doi： 10.18240/ijo.2021.04.19 http://dx.doi.org/10.18240/ijo.2021.04.19 .

Ding W ， Jiang D ， Tian Y ， et al . The effect of the back optic zone diameter on the treatment zone area and axial elongation in orthokeratology ［J］. Cont Lens Anterior Eye ， 2024 ， 47 （ 2 ）： 102131 . doi： 10.1016/j.clae.2024.102131 http://dx.doi.org/10.1016/j.clae.2024.102131 .

Jiang Y ， Zhu Z ， Tan X ， et al . Effect of repeated low-level red-light therapy for myopia control in children： a multicenter randomized controlled trial ［J］. Ophthalmology ， 2022 ， 129 （ 5 ）： 509 - 519 . doi： 10.1016/j.ophtha.2021.11.023 http://dx.doi.org/10.1016/j.ophtha.2021.11.023 .

樊泽民，刘立京，王海涛 . 扎实推进全国儿童青少年近视防控工作［J］. 中国学校卫生， 2018 ， 39 （ 11 ）： 1605 - 1608 . doi： 10.16835/j.cnki.1000-9817.2018.11.002 http://dx.doi.org/10.16835/j.cnki.1000-9817.2018.11.002 .

何鲜桂，潘臣炜 . 儿童青少年近视防控需要更高质量的研究证据［J］. 中国学校卫生， 2021 ， 42 （ 2 ）： 161 - 164 . doi： 10.16835/j.cnki. 1000-9817.2021.02.001 http://dx.doi.org/10.16835/j.cnki.1000-9817.2021.02.001 .

Ang M ， Flanagan JL ， Wong CW ， et al . Review：myopia control strategies recommendations from the 2018 WHO/IAPB/BHVI meeting on myopia ［J］. Br J Ophthalmol ， 2020 ， 104 （ 11 ）： 1482 - 1487 . doi： 10.1136/bjophthalmol-2019-315575 http://dx.doi.org/10.1136/bjophthalmol-2019-315575 .

聂桥，冯柯红，季建刚，等 . 户外活动与近视相关性研究进展［J］. 中国公共卫生， 2020 ， 36 （ 6 ）： 867 - 869 . doi： 10.11847/zgggws1120061 http://dx.doi.org/10.11847/zgggws1120061 .

张艳玲，查屹，邢丽娟，等 . 0.01%低浓度阿托品滴眼液对近视儿童调节功能和视疲劳的影响研究［J］. 中国斜视与小儿眼科杂志， 2021 ， 29 （ 3 ）： 7 - 10 . doi： 10.3969/J.ISSN.1005-328X.2021.03.003 http://dx.doi.org/10.3969/J.ISSN.1005-328X.2021.03.003 .

刘艺，于明坤，孙伟，等 . 角膜塑形术控制儿童近视有效性与安全性的Meta分析［J］. 山东大学耳鼻喉眼学报， 2021 ， 35 （ 6 ）： 92 - 100 . doi： 10.6040/j.issn.1673-3770.0.2021.037 http://dx.doi.org/10.6040/j.issn.1673-3770.0.2021.037 .

马润庭，周炼红 . 脉络膜血流灌注与儿童近视的相关性研究进展［J］. 国际眼科杂志， 2023 ， 23 （ 2 ）： 236 - 239 . doi： 10.3980/j.issn. 1672-5123.2023.2.11 http://dx.doi.org/10.3980/j.issn.1672-5123.2023.2.11 .

徐玲，易敬林，杜红岩 . 近视儿童黄斑中心凹下脉络膜厚度的变化特征及影响因素［J］. 国际眼科杂志， 2021 ， 21 （ 3 ）： 540 - 544 . doi： 10.3980/j.issn.1672-5123.2021.3.34 http://dx.doi.org/10.3980/j.issn.1672-5123.2021.3.34 .

童宇婷，马晓琪，周跃华 . 儿童青少年佩戴角膜塑形镜后不同时间点脉络膜厚度变化的Meta分析［J］. 中医眼耳鼻喉杂志， 2023 ， 13 （ 4 ）： 185 - 189 . doi： 10.3969/j.issn.1674-9006.2023.04.002 http://dx.doi.org/10.3969/j.issn.1674-9006.2023.04.002 .

郭姿彤，韩惠芳 . 重复低强度红光疗法防控近视的研究进展［J］. 中国斜视与小儿眼科杂志， 2024 ， 32 （ 3 ）： 47 - 48 . doi： 10.3969/J.ISSN.1005-328X.2024.03.015 http://dx.doi.org/10.3969/J.ISSN.1005-328X.2024.03.015 .

潘玉，梁艳，王冰 . 红光闪烁治疗仪结合红色视力表远距离视功能训练对近视性弱视患儿屈光度及视力的影响［J］. 世界复合医学， 2022 ， 8 （ 7 ）： 18 - 22 . doi： 10.3969/j.issn.1671-5217.2023. 25.037 http://dx.doi.org/10.3969/j.issn.1671-5217.2023.25.037 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Efficacies of different correction methods on adolescents with low-to-moderate unilateral myopia

Related Author

CHEN Li

LIU Bo

YANG Wei

HE Min

HUO Shu-jia

Related Institution

Qianye Eye Hospital

Department of Ophthalmology，First Affiliated Hospital of Army Medical University/Chongqing Key Laboratory of Visual Impairment and Regeneration & Repair

⁰