MA Wu-yan,LI Hui,LIU Zi-jun.Application of 3D-printed aortic root model in preoperative evaluation of transcatheter aortic valve replacement surgery[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(02):115-119.
MA Wu-yan,LI Hui,LIU Zi-jun.Application of 3D-printed aortic root model in preoperative evaluation of transcatheter aortic valve replacement surgery[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2026,35(02):115-119. DOI: 10.11659/jjssx.04E025025.
Application of 3D-printed aortic root model in preoperative evaluation of transcatheter aortic valve replacement surgery
To construct 3D-printed models of the aortic root based on contrast-enhanced CT angiography (CTA) data and to explore their application value in the preoperative evaluation of transcatheter aortic valve replacement (TAVR).
Methods
2
Twenty-one patients with aortic valve disease were enrolled from Linfen People's Hospital.All patients underwent CTA of the aorta and coronary arteries.The aortic root was reconstructed using Mimics medical imaging software and subsequently printed into 3D models. Parameters including the aortic annulus maximum and minimum diameters of junction of the aortic sinus and the sinus canal,as well as the aortic valve area and perimeter,and the distance from the coronary ostia to the annulus,were measured on both the CTA images and the 3D-printed models.Statistical analysis was performed to compare the two sets of measurements. The parameters of the aortic annulus and coronary ostia were measured and the calcification and vascular access conditions were evaluated on the 3D-printed model,and preoperative planning was carried out based on the above evaluation results to avoid surgical risks.Echocardiographic and electrocardiographic data before and after surgery were compared.
Results
2
There were no statistically significant differences in terms of the diameter of the aortic annulus,the aortic valve area and perimeter,the distance from the coronary ostia to the annulus,or the diameter of junction of the aortic sinus and the sinus canal between CTA and 3D-printed models (
P
>
0.05). Among the 21 patients, 18 cases underwent TAVR alone, while 3 cases received TAVR combined with coronary intervention. Based on the 3D-printed models, high risk of coronary obstruction was predicted in 5 cases, and protective measures were successfully implemented during surgery, with no coronary obstruction occurring. The agreement rate between the valve size preselected using the 3D-printed models and the size actually implanted was 90.5% (19/21), no perivalvular leakage occurred during the perioperative period.There were significant differences in the transvalvular pressure gradient, left v
entricular ejection fraction (LVEF), left ventricular end-diastolic diameter, and the proportion of patients with NYHA cardiac function classification Ⅳ 3 months,6 months,12 months after surgery compared with those before surgery (
P
<
0.05).
Conclusion
2
3D-printed model of the aortic root constructed based on CTA can accurately replicate aortic root anatomy.Preoperative planning utilizing these models can effectively reduce the risk of intraoperative coronary obstruction and the incidence of postoperative paravalvular leakage.
Lind AY , Totzeck M , Rassaf T , et al . Aortic stenosis - selection of the appropriate TAVR patient [J]. MMW Fortschr Med , 2021 , 163 ( 7 ): 46 - 53 . doi: 10.1007/s15006-021-9714-0 http://dx.doi.org/10.1007/s15006-021-9714-0 .
Bor WL , DChan Pin Yin DRPP , Brouwer J , et al . Assessment of the academic research consortium for high bleeding risk criteria in patients undergoing TAVR [J]. JACC Cardiovasc Interv , 2021 , 14 ( 11 ): 1265 - 1267 . doi: 10.1016/j.jcin.2021.01.007 http://dx.doi.org/10.1016/j.jcin.2021.01.007 .
Mendiz OA , No M , Fava CM , et al . Impact of cusp-overlap view for TAVR with self-expandable valves on 30-day conduction disturbances [J]. J Interv Cardiol , 2021 : 9991528 . doi: 10.1155/2021/9991528 http://dx.doi.org/10.1155/2021/9991528 .
Ma Y , Mao Y , Zhu G , et al . Application of cardiovascular 3-dimensional printing in transcatheter aortic valve replacement [J]. Cell Regen , 2022 , 11 ( 1 ): 35 . doi: 10.1186/s13619-022-00129-4 http://dx.doi.org/10.1186/s13619-022-00129-4 .
Levin D , Mackensen GB , Reisman M , et al . 3D printing applications for transcatheter aortic valve replacement [J]. Curr Cardiol Rep , 2020 , 22 ( 4 ): 23 . doi: 10.1007/s11886-020-1276-8 http://dx.doi.org/10.1007/s11886-020-1276-8 .
Xenofontos P , Zamani R , Akrami M . The application of 3D printing in preoperative planning for transcatheter aortic valve replacement: a systematic review [J]. Biomed Eng Online , 2022 , 21 ( 1 ): 59 . doi: 10.1186/s12938-022-01029-z http://dx.doi.org/10.1186/s12938-022-01029-z .
Russo JJ , Yuen T , Tan J , et al . Assessment of coronary artery obstruction risk during transcatheter aortic valve replacement utilising 3D-printing [J]. Heart Lung Circ , 2022 , 31 ( 8 ): 1134 - 1143 . doi: 10.1016/j.hlc.2022.01.007 http://dx.doi.org/10.1016/j.hlc.2022.01.007 .
Ripley B , Kelil T , Cheezum MK , et al . 3D printing based on cardiac CT assists anatomic visualization prior to transcatheter aortic valve replacement [J]. J Cardiovasc Comput Tomogr , 2016 , 10 ( 1 ): 28 - 36 . doi: 10.1016/j.jcct.2015.12.004 http://dx.doi.org/10.1016/j.jcct.2015.12.004 .
Aigner P , Sella Bart E , Panfili S , et al . Quantification of paravalvular leaks associated with TAVI implants using 4D MRI in an aortic root phantom made possible by the use of 3D printing [J]. Front Cardiovasc Med , 2023 , 10 : 1083300 . doi: 10.3389/fcvm.2023. 1083300 http://dx.doi.org/10.3389/fcvm.2023.1083300 .
Crascì F , Cannata S , Gandolfo C , et al . Evaluating the accuracy of 3D printing and finite element analysis in transcatheter aortic valveimplantation: a comparative study against post-TAVI CT imaging [J]. J Med Eng Technol , 2025 , 49 ( 7 ): 315 - 324 . doi: 10.1080/03091902. 2025.2540127 http://dx.doi.org/10.1080/03091902.2025.2540127 .