Abdominal full-thickness skin graft combined with adipose stem cells in repairing soft tissue defects after resection of facial benign tumors

PAN Xiao-feng; WANG Pei-pei; LIU Kun; ZHANG Miao-miao; DING Wen-yuan

doi:10.11659/jjssx.03E024136

您当前的位置：

首页 >

文章列表页 >

Abdominal full-thickness skin graft combined with adipose stem cells in repairing soft tissue defects after resection of facial benign tumors

Clinical Research | 更新时间：2025-05-26

- Abdominal full-thickness skin graft combined with adipose stem cells in repairing soft tissue defects after resection of facial benign tumors
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 5, Pages: 408-412(2025)
- 作者机构：
  
  第七十一集团军医院烧伤整形科，江苏徐州 221004
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.03E024136
  CLC： R622
- Received：26 March 2024，
  
  Published：25 May 2025
- 稿件说明：
移动端阅览
潘晓峰,王培培,刘坤等.腹部全厚皮片联合脂肪干细胞修复面部良性肿瘤切除术后软组织缺损[J].局解手术学杂志,2025,34(05):408-412.

PAN Xiao-feng,WANG Pei-pei,LIU Kun,et al.Abdominal full-thickness skin graft combined with adipose stem cells in repairing soft tissue defects after resection of facial benign tumors[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(05):408-412.
潘晓峰,王培培,刘坤等.腹部全厚皮片联合脂肪干细胞修复面部良性肿瘤切除术后软组织缺损[J].局解手术学杂志,2025,34(05):408-412. DOI： 10.11659/jjssx.03E024136.

PAN Xiao-feng,WANG Pei-pei,LIU Kun,et al.Abdominal full-thickness skin graft combined with adipose stem cells in repairing soft tissue defects after resection of facial benign tumors[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(05):408-412. DOI： 10.11659/jjssx.03E024136.

摘要

目的

观察腹部全厚皮片联合脂肪干细胞修复面部良性肿瘤切除术后软组织缺损的临床效果。

方法

选取我院2019年1月至2022年6月面部良性肿瘤切除术后软组织缺损患者180例，采用双盲法设计研究，并采用随机数字表法分为观察组和对照组，每组90例。对照组患者采用腹部全厚皮片修复治疗，观察组患者采用腹部全厚皮片联合脂肪干细胞修复治疗。对比2组患者面部术区瘢痕状态评分、临床疗效、并发症发生率以及患者满意度情况。

结果

与术前比较，术后6个月2组患者面部瘢痕色泽、厚度、血管分布及柔软度评分均降低，差异有统计学意义（

0.05）；术后6个月观察组患者瘢痕色泽、厚度、血管分布及柔软度评分明显低于对照组（

0.05）；观察组患者额部、鼻部、眼睑部、唇部、颊部的有效率与对照组比较，差异无统计学意义（

0.05）；观察组患者总有效率显著高于对照组（

0.05）；2组患者并发症发生率比较，差异无统计学意义（

0.05）；2组患者满意度分布对比，差异有统计学意义（

0.05），观察组患者的满意度明显高于对照组（

0.05）。

结论

腹部全厚皮片联合脂肪干细胞修复面部良性肿瘤切除术后软组织缺损能够改善面部瘢痕状态，提高修复效果和患者满意度，且安全性高。

Abstract

Objective

To observe the clinical effect of abdominal full-thickness skin graft combined with adipose stem cells in repairing soft tissue defects after resection of facial benign tumors.

Methods

A total of 180 patients with soft tissue defects after resection of facial benign tumor in our hospital from January 2019 to June 2022 were selected，the study was designed by a double-blind method，and patients were divided into the observation group and the control group by a random number table method，with 90 cases in each group. Patients in the control group were repaired by abdominal full-thickness skin graft treatment，while these in the observation group were repaired by a combination of abdominal full-thickness skin graft and adipose stem cells. The scar status scores in the surgical area，clinical efficacy，incidence of complications and satisfaction of patients in the two groups were compared.

Results

Compared with preoperative results，the scores of color and thickness of scars，vascular distribution，and softness in face 6 months after surgery in both groups decreased，with statistically significant differences（

0.05）. Six months after surgery，the observation group had significantly lower scores on scar color and thickness，vascular distribution，and softness compared to the control group （

0.05）； there was no difference in the effective rate of the forehead，nose，eyelids，lips，or cheeks between the observation group and the control group（

0.05）； while the observation group had higher overall effective rate than the control group （

0.05）.There was no statistically significant difference in the incidence of complications between the two groups （

0.05）.There was statistically significant difference in the distribution of the satisfaction of patients between the two groups （

0.05），and the observation group showed significantly higher satisfaction of patients than the control group （

0.05）.

Conclusion

Abdominal full-thickness skin graft combined with adipose stem cells can improve facial scars in repairing soft tissue defects after resection of facial benign tumors，and enhance the repair effects and satisfaction of patients，with high safety.

关键词

Keywords

references

韦彦锋，曹建广 . 不同皮瓣对口腔颌面部肿瘤根治术后缺损的修复效果比较［J］. 实用癌症杂志， 2018 ， 33 （ 10 ）： 73 - 75 . doi： 10.3969/j.issn.1001-5930.2018.10.020 http://dx.doi.org/10.3969/j.issn.1001-5930.2018.10.020 .

聂芬，孙鹏飞，刘聪，等 . 局部皮瓣修复肿瘤切除术后头面部皮肤软组织缺损［J］. 青岛大学学报（医学版）， 2020 ， 56 （ 1 ）： 72 - 75 . doi： 10.11712/jms.2096-5532.2020.56.003 http://dx.doi.org/10.11712/jms.2096-5532.2020.56.003 .

Samal CC ， Dash S ， Agrawal K ， et al . Comparative evaluation of three methods of skin graft fixation for split thickness skin graft after release of post burn contracture of the neck ［J］. Burns ， 2019 ， 45 （ 3 ）： 691 - 698 . doi： 10.1016/j.burns.2018.09.030 http://dx.doi.org/10.1016/j.burns.2018.09.030 .

Jones CM ， Mackay DR . Autologous fat grafting in cleft lip and palate ［J］. J Craniofac Surg ， 2019 ， 30 （ 3 ）： 686 - 691 . doi： 10.1097/SCS.0000000000005205 http://dx.doi.org/10.1097/SCS.0000000000005205 .

熊俊文，陈守正，徐文捷 . 自体脂肪移植在面部轮廓整形中的应用［J］. 组织工程与重建外科杂志， 2019 ， 15 （ 1 ）： 42 - 44 . doi： 10.3969/j.issn.1673-0364.2019.01.010 http://dx.doi.org/10.3969/j.issn.1673-0364.2019.01.010 .

Drochioi CI ， Sulea D ， Timofte D ， et al . Autologous fat grafting for craniofacial reconstruction in oncologic patients ［J］. Medicina （Kaunas）， 2019 ， 55 （ 10 ）： 1 - 14 . doi： 10.3390/medicina55100655 http://dx.doi.org/10.3390/medicina55100655 .

赵伟，廖农，王君，等 . 自体脂肪及脂肪干细胞填充治疗面部老化的疗效［J］. 中国现代医学杂志， 2019 ， 29 （ 13 ）： 94 - 97 . doi： 10.3969/j.issn.1005-8982.2019.13.018 http://dx.doi.org/10.3969/j.issn.1005-8982.2019.13.018 .

Yoon PW ， Kang JY ， Kim CH ， et al . Culture-expanded autologous adipose-derived mesenchymal stem cell treatment for osteonecrosis of the femoral head ［J］. Clin Orthop Surg ， 2021 ， 13 （ 1 ）： 37 - 46 . doi： 10.4055/cios20128 http://dx.doi.org/10.4055/cios20128 .

Horiguchi M ， Hata S ， Tsurudome Y ， et al . Characterizing the degeneration of nuclear membrane and mitochondria of adipose-derived mesenchymal stem cells from patients with type Ⅱ diabetes ［J］. J Cell Mol Med ， 2021 ， 25 （ 9 ）： 4298 - 4306 . doi： 10.1111/jcmm.16484 http://dx.doi.org/10.1111/jcmm.16484 .

Yao Y ， Dong DQ ， Liao YJ ， et al . Adipose extracellular matrix/stromal vascular fraction gel：a novel adipose tissue-derived injectable for stem cell therapy ［J］. Plast and Reconstr Surg ， 2017 ， 139 （ 4 ）： 867 - 879 . doi： 10.1097/PRS.0000000000003214 http://dx.doi.org/10.1097/PRS.0000000000003214 .

罗靖，高娴玲，邵建林，等 . 铁死亡在脑缺血再灌注损伤机制中的研究进展［J］. 局解手术学杂志， 2020 ， 29 （ 11 ）： 932 - 936 . doi： 10.11659/jjssx.05E020177 http://dx.doi.org/10.11659/jjssx.05E020177 .

中国抗癌协会 . 中国抗癌协会乳腺肿瘤整形外科整合诊治指南（精简版）［J］. 中华肿瘤杂志， 2024 ， 46 （ 12 ）： 1234 - 1242 . doi： 10.12354/j.issn.1000-8179.2024.20241589 http://dx.doi.org/10.12354/j.issn.1000-8179.2024.20241589 .

Zhang XF ， Chu Z ， Yang HL ， et al . The tumor plastic surgery technology versus traditional repair technology on the repair of large-area skin defects after maxillofacial tumor resection： a randomized controlled trial ［J］. J Oral Maxillofac Surg ， 2023 ， 81 （ 5 ）： 1234 - 1245 . doi： 10.1016/j.joms.2023.01.001 http://dx.doi.org/10.1016/j.joms.2023.01.001 .

Gao Y ， Gao B ， Zhu H ， et al . Adipose-derived stem cells embedded in platelet-rich plasma scaffolds improve the texture of skin grafts in a rat full-thickness wound model ［J］. Burns ， 2020 ， 46 （ 3 ）： 377 - 385 . doi： 10.1016/j.burns.2019.07.041 http://dx.doi.org/10.1016/j.burns.2019.07.041 .

陈友慈，廖坚文，李灿彬 . 全厚皮片联合封闭负压引流装置修复皮肤撕脱伤的应用效果分析［J］. 广东医学， 2018 ， 39 （ 9 ）： 116 - 119 . doi： 10.3969/j.issn.1001-9448.2018.09.027 http://dx.doi.org/10.3969/j.issn.1001-9448.2018.09.027 .

Pennati A ， Riggio E ， Marano G ， et al . Autologous fat grafting after sarcoma surgery：evaluation of oncological safety ［J］. J Plast Reconstr Aesthet Surg ， 2018 ， 71 （ 12 ）： 1723 - 1729 . doi： 10.1016/j.bjps.2018.07.028 http://dx.doi.org/10.1016/j.bjps.2018.07.028 .

王一，龚思宇，姜笃银 . 脂肪干细胞及其衍生物促慢性创面愈合的研究进展［J］. 中国美容医学， 2024 ， 33 （ 4 ）： 179 - 182 . doi： 10.3760/cma.j.cn501120-20240420-00296 http://dx.doi.org/10.3760/cma.j.cn501120-20240420-00296 .

Clauser L ， Zavan B ， Galiè M ， et al . Autologous fat transfer for facial augmentation：surgery and regeneration ［J］. J Craniofac Surg ， 2019 ， 30 （ 3 ）： 682 - 685 . doi： 10.1016/j.cxom.2017.10.002 http://dx.doi.org/10.1016/j.cxom.2017.10.002 .

陈艳萍，蔡亮 . 自体脂肪移植与吻合血管股前外侧筋膜脂肪瓣移植术对PHFA面部软组织缺损疗效分析［J］. 中国医师杂志， 2018 ， 20 （ 8 ）： 1183 - 1186 . doi： 10.3760/cma.j.issn.1008-1372.2018.08.017 http://dx.doi.org/10.3760/cma.j.issn.1008-1372.2018.08.017 .

De Santis G ， Pinelli M ， Benanti E ， et al . Lipofilling after laser-assisted treatment for facial filler complication：volumetric and regenerative effect ［J］. Plast Reconstr Surg ， 2021 ， 147 （ 3 ）： 585 - 591 . doi： 10.1097/PRS.0000000000007611 http://dx.doi.org/10.1097/PRS.0000000000007611 .

冉力，刘林奇，李娅萍 . PRP与SVF-gel辅助自体脂肪移植手术的效果观察［J］. 局解手术学杂志， 2020 ， 29 （ 7 ）： 573 - 577 . doi： 10.11659.jjssx/03E020165 http://dx.doi.org/10.11659.jjssx/03E020165 .

周峰，李强，黄理旭，等 . 基质血管成分细胞与脂肪来源干细胞在全厚皮片移植中的作用比较［J］. 中国美容整形外科杂志， 2019 ， 30 （ 8 ）： 491 - 494 . doi： 10.3969/j.issn.1673-7040.2019.08.015 http://dx.doi.org/10.3969/j.issn.1673-7040.2019.08.015 .

欧令东，张爱君，李昂，等 . 人脂肪来源干细胞胶治疗皮肤凹陷性瘢痕患者的作用及其机制［J］. 中华烧伤杂志， 2019 ， 35 （ 12 ）： 859 - 865 . doi： 10.3760/cma.j.issn.1009-2587.2019.12.006 http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.12.006 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Ilizarov technique in treatment of Gustilo type Ⅲ B and C of large tibia bone defect combined with soft tissue defect

Related Author

XIAO Wei-dong

YU Ai-xi

PAN Zhen-yu

TAO Shen-xiang

HU Xiang

YUAN Ying

WANG Zheng

Related Institution

Department of Orthopedics,Central South Hospital,Wuhan University

⁰