Mammographic imaging features of breast cancer and its correlation with microvascular density

MA Li-qin; LIU Li; HU Heng-li; CHEN Yu-lei; CHEN Long-zhou; HAN Zhi-gang

doi:10.11659/jjssx.03E024066

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Mammographic imaging features of breast cancer and its correlation with microvascular density

Clinical Research | 更新时间：2025-03-25

- Mammographic imaging features of breast cancer and its correlation with microvascular density
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 3, Pages: 258-262(2025)
- 作者机构：
  
  1.扬州大学医学院附属淮安市妇幼保健院放射科，江苏淮安223002
  2.新疆生产建设兵团第七师医院放射科，新疆伊犁833200
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.03E024066
  CLC： R445.4
- Received：12 March 2024，
  
  Published：25 March 2025
- 稿件说明：
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马利芹,刘丽,胡恒利等.乳腺癌钼靶影像学特征及其与微血管密度的相关性分析[J].局解手术学杂志,2025,34(03):258-262.

MA Li-qin,LIU Li,HU Heng-li,et al.Mammographic imaging features of breast cancer and its correlation with microvascular density[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(03):258-262.
马利芹,刘丽,胡恒利等.乳腺癌钼靶影像学特征及其与微血管密度的相关性分析[J].局解手术学杂志,2025,34(03):258-262. DOI： 10.11659/jjssx.03E024066.

MA Li-qin,LIU Li,HU Heng-li,et al.Mammographic imaging features of breast cancer and its correlation with microvascular density[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(03):258-262. DOI： 10.11659/jjssx.03E024066.

摘要

目的

分析乳腺癌钼靶影像学特征及其与微血管密度（MVD）的相关性。

方法

选取2019年1月至2022年12月于新疆生产建设兵团第七师医院就诊并经手术病理证实为乳腺癌的患者86例作为研究对象。根据修改后的布鲁姆理查森评分系统，将乳腺癌患者分为组织学Ⅰ级（

=22）、Ⅱ级（

=25）和Ⅲ级（

=39）。所有患者术前均完善钼靶影像学检查，术后均行免疫组化并计数MVD。采用

Spearman

秩相关分析不同组织学分级乳腺癌患者MVD与钼靶影像特征的相关性。

结果

乳腺癌病灶组织微血管阳性表达率为100%，每视野MVD计数为14~276条，平均（72.58±16.37）条，其中组织学Ⅰ~Ⅱ级的患者MVD计数为14~175条，平均（42.10±13.51）条；组织学Ⅲ级的患者MVD计数为22~276条，平均（93.82±22.17）条。组织学Ⅲ级患者MVD计数明显高于组织学Ⅰ~Ⅱ级，差异有统计学意义（

=19.627，

0.001）。组织学Ⅲ级乳腺癌患者边缘不光整、毛刺征、腋窝淋巴结转移和细小颗粒钙化出现率均高于组织学Ⅰ~Ⅱ级，差异有统计学意义（

0.05）。乳腺癌患者表现为边缘不光整、毛刺征、腋窝淋巴结转移和细小颗粒钙化时，其MVD计数均高于边缘光整、无毛刺征、无腋窝淋巴结转移和无细小颗粒钙化，与组织学分级呈正相关（

0.05）。

结论

乳腺癌部分钼靶影像学特征可在一定程度上反映肿瘤血管生成情况，为疾病的治疗及预后提供重要参考，具有一定临床价值。

Abstract

Objective

To investigate the mammographic imaging features of breast cancer and its correlation with microvascular density （MVD）.

Methods

A total of 86 patients with breast cancer confirmed by surgical pathology in Xinjiang Production and Construction Corps 7th Division Hospital from January 2019 to December 2022 were selected as the research objects. According to the modified Bloom Richardson scoring system， the breast cancer patients were classified into histological grade Ⅰ （

=22）， grade Ⅱ （

=25） and grade Ⅲ （

=39）. All patients underwent preoperative mammographic imaging examination. Immunohistochemistry staining was performed and MVD count was conducted after operation.

Spearman

rank correlation was used to analyze the correlation between MVD of breast cancer with different histological grades and mammographic imaging features.

Results

The microvascular positive expression rate of breast cancer lesions was 100%，the MVD counts per visual field were 14~276 vessels， with an average of （72.58±16.37） vessels， of which the MVD counts of patients with histological grade Ⅰ to Ⅱ were 14 to 175 vessels， with an average of （42.10±13.51） vessels； the MVD counts of patients with histological grade Ⅲ was 22~276 vessels， with an average of （93.82±22.17） vessels. The MVD counts of patients with histological grade Ⅲ was significantly higher than that of patients with histological grade Ⅰ to Ⅱ，with statistically significant difference （

=19.627，

0.001）.The

incidences of irregular margin， spicular sign， axillary lymph node metastasis and fine particle calcification in patients with histological grade Ⅲ were higher than those in patients with histological grade Ⅰ to Ⅱ， with statistically significant difference （

0.05）. The MVD counts of breast cancer patients with irregular margin， spicular sign， axillary lymph node metastasis and fine particle calcification were higher than those of patients with smooth margin and without spicular sign，axillary lymph node metastasis or fine particle calcification，which was positively correlated with histological grades （

0.05）.

Conclusion

Some mammographic imaging features of breast cancer can reflect tumor angiogenesis to a certain extent，which can provide important reference for the treatment and prognosis of the disease，with certain clinical value.

关键词

Keywords

references

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