Research progress in neoadjuvant therapy for locally advanced rectal cancer

HU Yu-fei; SUN Yue; FU Yan; LI Heng

doi:10.11659/jjssx.02E024043

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Research progress in neoadjuvant therapy for locally advanced rectal cancer

Review | 更新时间：2025-01-21

- Research progress in neoadjuvant therapy for locally advanced rectal cancer
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 2, Pages: 178-182(2025)
- 作者机构：
  
  1.湖北省十堰市太和医院/湖北医药学院附属医院普外科，湖北十堰 442000
  2.湖北省十堰市郧阳区人民医院胃肠外科，湖北十堰 442500
  3.湖北省十堰市人民医院/湖北医药学院附属人民医院医养中心，湖北十堰 442000
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.02E024043
  CLC： R735.3+7
- Published：25 February 2025，
  
  Received：21 February 2024，
- 稿件说明：
移动端阅览
HU YU-FEI, SUN YUE, FU YAN, et al. Research progress in neoadjuvant therapy for locally advanced rectal cancer. [J]. Journal of regional anatomy and operative surgery, 2025, 34(2): 178-182.
DOI：

HU YU-FEI, SUN YUE, FU YAN, et al. Research progress in neoadjuvant therapy for locally advanced rectal cancer. [J]. Journal of regional anatomy and operative surgery, 2025, 34(2): 178-182. DOI： 10.11659/jjssx.02E024043.

摘要

直肠癌是最常见的消化道恶性肿瘤之一，早期直肠癌患者仅行手术治疗即可达到肿瘤根治的目的，但大多数直肠癌患者就诊时已处于局部进展期阶段。针对这一类人群，单纯通过手术治疗难以获得较好的预后，手术前行干预性放化疗具有重要的临床意义。大量临床研究证明，术前行新辅助治疗可以有效降低肿瘤分期，提高病理完全缓解（pCR）率，极大改善患者的预后。目前，局部进展期直肠癌新辅助治疗的核心手段是放疗、化疗以及新兴的靶向、免疫治疗等，但各种治疗的最佳组合顺序仍存在较大争议，本文就近些年各种新辅助治疗方案进行总结，为直肠癌多学科合作综合治疗提供证据。

Abstract

Rectal cancer is one of the most common gastrointestinal malignant tumors，and patients with early rectal cancer can achieve radical tumor resection by surgical treatment alone，while most patients with rectal cancer are in the locally advanced stage when admitted to hospital. For this group of people，it is difficult to obtain a good prognosis through surgical treatment alone，and interventional chemoradiotherapy before surgery is of important clinical significance. A large number of clinical studies have proved that preoperative neoadjuvant therapy can effectively reduce tumor stage，increase pathological complete response （pCR） rate，thereby greatly improving the prognosis of patients. At present，the core methods of neoadjuvant therapy for locally advanced rectal cancer are radiotherapy and chemotherapy，as well as the emerging targeted therapy and immunotherapy，while the optimal combination order of various treatments remains in dispute.This article summarizes various neoadjuvant therapy regimens in recent years，in order to provide evidence for the multidisciplinary and comprehensive treatment of rectal cancer.

关键词

直肠癌局部进展期新辅助治疗新辅助放化疗

Keywords

rectal cancerlocally advanced stageneoadjuvant therapyneoadjuvant chemoradiotherapy

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