Multimodal MRI features of cerebral small vessel disease combined with type 2 diabetes mellitus

WANG Jing; PAN Hang; ZHENG Yan-ling; LIANG Zi-wen; WANG Yu-lin; OU Qiu-guo; GUAN Fan-ying; TAO Hai-yan; SONG Lei; TANG Rui

doi:10.11659/jjssx.01E025017

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Multimodal MRI features of cerebral small vessel disease combined with type 2 diabetes mellitus

Clinical Research | 更新时间：2025-07-31

- Multimodal MRI features of cerebral small vessel disease combined with type 2 diabetes mellitus
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 8, Pages: 689-692(2025)
- 作者机构：
  
  1.陆军军医大学第一附属医院内分泌科，重庆 400038
  2.陆军军医大学第一附属医院健康管理中心，重庆 400038
  3.陆军军医大学第一附属医院骨科，重庆 400038
  4.陆军军医大学第一附属医院门诊部，重庆 400038
- 作者简介：
- 基金信息：
- DOI：10.11659/jjssx.01E025017
  CLC： R743
- Received：05 January 2025，
  
  Published：25 August 2025
- 稿件说明：
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王静,潘航,郑焱玲等.2型糖尿病脑小血管病的多模态MRI特征分析[J].局解手术学杂志,2025,34(08):689-692.

WANG Jing,PAN Hang,ZHENG Yan-ling,et al.Multimodal MRI features of cerebral small vessel disease combined with type 2 diabetes mellitus[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(08):689-692.
王静,潘航,郑焱玲等.2型糖尿病脑小血管病的多模态MRI特征分析[J].局解手术学杂志,2025,34(08):689-692. DOI： 10.11659/jjssx.01E025017.

WANG Jing,PAN Hang,ZHENG Yan-ling,et al.Multimodal MRI features of cerebral small vessel disease combined with type 2 diabetes mellitus[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(08):689-692. DOI： 10.11659/jjssx.01E025017.

摘要

目的

采用多模态MRI技术分析2型糖尿病脑小血管病患者的影像学特征。

方法

回顾性分析我院2020年1—12月收治的160例脑小血管病患者的临床资料，根据是否合并2型糖尿病将患者分为糖尿病组和非糖尿病组，每组80例。2组患者均行多模态MRI扫描，比较2组患者腔隙性脑梗死严重程度、皮层下及脑室周围脑白质病变严重程度、白质积分、脑微出血情况。

结果

糖尿病组患者腔隙性脑梗死严重程度（

²=34.076，

=0.001）、皮层下脑白质病变严重程度（

²=25.000，

=0.001）、脑室周围脑白质病变严重程度（

²=22.895，

=0.001）及白质积分（

=12.370，

0.001）均显著高于非糖尿病组。2组患者均未检出脑微出血。

结论

合并2型糖尿病的脑小血管病患者表现出特征性的多模态MRI改变，腔隙性脑梗死病灶数量增多及脑白质病变程度加重可作为诊断2型糖尿病相关脑小血管病的特征性影像学依据。

Abstract

Objective

To analyze the imaging features of cerebral small vessel disease in patients with type 2 diabetes mellitus by multimodal MRI.

Methods

The clinical data of 160 patients with cerebral small vessel disease admitted to our hospital from January to December 2020 were retrospectively analyzed. According to whether they were complicated with type 2 diabetes mellitus， they were divided into the diabetic group and the non-diabetic group， with 80 cases in each group.Both groups underwent multimodal MRI scans. And the severity of lacunar infarction， the severity of subcortical and periventricular white matter lesions， white matter integral and cerebral microbleeds of patients in the two groups were compared.

Results

The severity of lacunar infarction （

²=34.076，

=0.001）， subcortical white matter lesions （

²=25.000，

=0.001）， periventricular white matter lesions （

²=22.895，

=0.001） and white matter integral （

=12.370，

=0.001） of patients in the diabetic group were significantly higher than those in the non-diabetic group.No cerebral microbleeds were detected in either group of patients.

Conclusion

Patients with cerebral small vessel disease and type 2 diabetes mellitus show characteristic multimodal MRI changes. The increase in the number of lacunar infarction lesions and the aggravation of white matter lesions can be used as the characteristic imaging basis for the diagnosis of type 2 diabetes mellitus related cerebral small vessel disease.

关键词

Keywords

references

Georgakis MK ， Harshfield EL ， Malik R ， et al . Diabetes mellitus，glycemic traits，and cerebrovascular disease：a mendelian randomization study ［J］. Neurology ， 2021 ， 96 （ 13 ）： e1732 - e1742 . doi： 10.1212/WNL.0000000000011555 http://dx.doi.org/10.1212/WNL.0000000000011555 .

Lee J ， Yun JS ， Ko SH . Advanced glycation end products and their effect on vascular complications in type 2 diabetes mellitus ［J］. Nutrients ， 2022 ， 14 （ 15 ）： 3086 . doi： 10.3390/nu14153086 http://dx.doi.org/10.3390/nu14153086 .

中华医学会放射学分会神经学组 . 脑小血管病MRI规范化应用专家共识［J］. 中华放射学杂志， 2024 ， 58 （ 1 ）： 6 - 17 . doi： 10.3760/cma.j.cn112149-20231031-00334 http://dx.doi.org/10.3760/cma.j.cn112149-20231031-00334 .

邓政豪，王金宝，陈小翠，等 . 多模态磁共振影像技术评估原发性三叉神经痛责任血管的应用价值［J］. 影像技术， 2025 ， 37 （ 2 ）： 24 - 28 . doi： 10.3969/j.issn.1001-0270.2025.02.05 http://dx.doi.org/10.3969/j.issn.1001-0270.2025.02.05 .

Shan Y ， Lin J ， Xu P ， et al . Association of aortic compliance and brachial endothelial function with cerebral small vessel disease in type 2 diabetes mellitus patients：assessment with high-resolution MRI ［J］. Biomed Res Int ， 2016 ： 1609317 . doi： 10.1155/2016/1609317 http://dx.doi.org/10.1155/2016/1609317 .

Xu Z ， Li F ， Xing D ， et al . A novel imaging biomarker for cerebral small vessel disease associated with cognitive impairment：the deep-medullary-veins score ［J］. Front Aging Neurosci ， 2021 ， 13 ： 720481 . doi： 10.3389/fnagi.2021.720481 http://dx.doi.org/10.3389/fnagi.2021.720481 .

Wardlaw JM ， Smith C ， Dichgans M . Mechanisms of sporadic cerebral small vessel disease：insights from neuroimaging ［J］. Lancet Neurol ， 2013 ， 12 （ 5 ）： 483 - 497 . doi： 10.1016/S1474-4422（13）70060-7 http://dx.doi.org/10.1016/S1474-4422（13）70060-7 .

Fazekas F ， Chawluk JB ， Alavi A ， et al . MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging ［J］. AJR Am J Roentgenol ， 1987 ， 149 （ 2 ）： 351 - 356 . doi： 10.2214/ajr.149.2.351 http://dx.doi.org/10.2214/ajr.149.2.351 .

戴瑛，田耘，范忠玲 . 糖尿病病人血管特点及穿刺方法的探讨［J］. 西南军医， 2011 ， 13 （ 1 ）： 163 - 164 . doi： 10.3969/j.issn.1672-7193.2011.01.093 http://dx.doi.org/10.3969/j.issn.1672-7193.2011.01.093 .

巫颖，李茜 . 心血管介入治疗中碘对比剂对肾功能的影响及其防治［J］. 内科， 2012 ， 7 （ 1 ）： 54 - 57 . doi： 10.3969/j.issn.1673-7768. 2012.01.031 http://dx.doi.org/10.3969/j.issn.1673-7768.2012.01.031 .

van Lanen R ， Colon AJ ， Wiggins CJ ， et al . Ultra-high field magnetic resonance imaging in human epilepsy：a systematic review ［J］. Neuroimage Clin ， 2021 ， 30 ： 102602 . doi： 10.1016/j.nicl.2021.102602 http://dx.doi.org/10.1016/j.nicl.2021.102602 .

Thomas KE ， Fotaki A ， Botnar RM ， et al . Imaging methods：magnetic resonance imaging ［J］. Circ Cardiovasc Imaging ， 2023 ， 16 （ 1 ）： e014068 . doi： 10.1161/CIRCIMAGING.122.014068 http://dx.doi.org/10.1161/CIRCIMAGING.122.014068 .

Stein EB ， Shampain KL . Magnetic resonance imaging of acute adnexal pathology ［J］. Magn Reson Imaging Clin N Am ， 2023 ， 31 （ 1 ）： 109 - 120 . doi： 10.1016/j.mric.2022.04.001 http://dx.doi.org/10.1016/j.mric.2022.04.001 .

Haller S ， Haacke EM ， Thurnher MM ， et al . Susceptibility-weighted imaging：technical essentials and clinical neurologic applications ［J］. Radiology ， 2021 ， 299 （ 1 ）： 3 - 26 . doi： 10.1148/radiol.2021203071 http://dx.doi.org/10.1148/radiol.2021203071 .

Wach-Klink A ， Iżycka-Świeszewska E ， Kozera G ， et al . Cerebral microbleeds in neurological practice：concepts，diagnostics and clinical aspects ［J］. Neurol Neurochir Pol ， 2021 ， 55 （ 5 ）： 450 - 461 . doi： 10.5603/PJNNS.a2021.0058 http://dx.doi.org/10.5603/PJNNS.a2021.0058 .

Pantoni L . Cerebral small vessel disease：from pathogenesis and clinical characteristics to therapeutic challenges ［J］. Lancet Neurol ， 2010 ， 9 （ 7 ）： 689 - 701 . doi： 10.1016/S1474-4422（10）70104-6 http://dx.doi.org/10.1016/S1474-4422（10）70104-6 .

Mayhan WG . Cerebral circulation during diabetes mellitus ［J］. Pharmacol Ther ， 1993 ， 57 （ 2-3 ）： 377 - 391 . doi： 10.1016/0163-7258（93）90062-i http://dx.doi.org/10.1016/0163-7258（93）90062-i .

Rensma SP ， van Sloten TT ， Ding J ， et al . Type 2 diabetes，change in depressive symptoms over time，and cerebral small vessel disease：longitudinal data of the AGES-reykjavik study ［J］. Diabetes Care ， 2020 ， 43 （ 8 ）： 1781 - 1787 . doi： 10.2337/dc19-2437 http://dx.doi.org/10.2337/dc19-2437 .

Pinti MV ， Fink GK ， Hathaway QA ， et al . Mitochondrial dysfunction in type 2 diabetes mellitus：an organ-based analysis ［J］. Am J Physiol Endocrinol Metab ， 2019 ， 316 （ 2 ）： E268 - E285 . doi： 10.1152/ajpendo. 00314.2018 http://dx.doi.org/10.1152/ajpendo.00314.2018 .

Maciejczyk M ， Żebrowska E ， Chabowski A . Insulin resistance and oxidative stress in the brain：what's new？［J］. Int J Mol Sci ， 2019 ， 20 （ 4 ）： 874 . doi： 10.3390/ijms20040874 http://dx.doi.org/10.3390/ijms20040874 .

Prasun P . Mitochondrial dysfunction in metabolic syndrome ［J］. Biochim Biophys Acta Mol Basis Dis ， 2020 ， 1866 （ 10 ）： 165838 . doi： 10.1016/j.bbadis.2020.165838 http://dx.doi.org/10.1016/j.bbadis.2020.165838 .

Chojdak-Łukasiewicz J ， Dziadkowiak E ， Zimny A ， et al . Cerebral small vessel disease：a review ［J］. Adv Clin Exp Med ， 2021 ， 30 （ 3 ）： 349 - 356 . doi： 10.17219/acem/131216 http://dx.doi.org/10.17219/acem/131216 .

Markus HS ， de Leeuw FE . Cerebral small vessel disease：recent advances and future directions ［J］. Int J Stroke ， 2023 ， 18 （ 1 ）： 4 - 14 . doi： 10.1177/17474930221144911 http://dx.doi.org/10.1177/17474930221144911 .

Wardlaw JM ， Smith EE ， Biessels GJ ， et al . Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration ［J］. Lancet Neurol ， 2013 ， 12 （ 8 ）： 822 - 838 . doi： 10.1016/S1474-4422（13）70124-8 http://dx.doi.org/10.1016/S1474-4422（13）70124-8 .

Banks WA . The blood-brain barrier interface in diabetes mellitus：dysfunctions，mechanisms and approaches to treatment ［J］. Curr Pharm Des ， 2020 ， 26 （ 13 ）： 1438 - 1447 . doi： 10.2174/138161282 6666200325110014 http://dx.doi.org/10.2174/1381612826666200325110014 .

Chen C ， Xu X ， Lu J ， et al . Hyperglycemia-induced blood-brain barrier dysfunction：mechanisms and therapeutic interventions ［J］. Microvasc Res ， 2025 ， 160 ： 104820 . doi： 10.1016/j.mvr.2025.104820 http://dx.doi.org/10.1016/j.mvr.2025.104820 .

Meng F ， Wang J ， Wang L ， et al . Glucose metabolism impairment in major depressive disorder ［J］. Brain Res Bull ， 2025 ， 221 ： 111191 . doi： 10.1016/j.brainresbull.2025.111191 http://dx.doi.org/10.1016/j.brainresbull.2025.111191 .

Zhu Y ， Verkhratsky A ， Chen H ， et al . Understanding glucose metabolism and insulin action at the blood-brain barrier：implications for brain health and neurodegenerative diseases ［J］. Acta Physiol （Oxf）， 2025 ， 241 （ 2 ）： e14283 . doi： 10.1111/apha.14283 http://dx.doi.org/10.1111/apha.14283 .

Chowen JA ， Frago LM ， Fernández-Alfonso MS . Physiological and pathophysiological roles of hypothalamic astrocytes in metabolism ［J］. J Neuroendocrinol ， 2019 ， 31 （ 5 ）： e12671 . doi： 10.1111/jne.12671 http://dx.doi.org/10.1111/jne.12671 .

Kosmopoulos M ， Drekolias D ， Zavras PD ， et al . Impact of advanced glycation end products （AGEs） signaling in coronary artery disease ［J］. Biochim Biophys Acta Mol Basis Dis ， 2019 ， 1865 （ 3 ）： 611 - 619 . doi： 10.1016/j.bbadis.2019.01.006 http://dx.doi.org/10.1016/j.bbadis.2019.01.006 .

Prasad A ， Bekker P ， Tsimikas S . Advanced glycation end products and diabetic cardiovascular disease ［J］. Cardiol Rev ， 2012 ， 20 （ 4 ）： 177 - 183 . doi： 10.1097/CRD.0b013e318244e57c http://dx.doi.org/10.1097/CRD.0b013e318244e57c .

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