Research progress on TGF-β in peripheral nervous regeneration
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 1, Pages: 84-88(2025)
- 作者机构：
1.四川大学华西医院康复医学中心，四川 成都 610041
2.宜宾市第二人民医院儿童康复科，四川 宜宾 644000
- 作者简介：
- 基金信息：
DOI：10.11659/jjssx.01E024124
CLC： R741.02Published：25 January 2025，
Received：26 January 2024，
- 稿件说明：
移动端阅览
TANG LI-QIANG, QU YUN. Research progress on TGF-β in peripheral nervous regeneration. [J]. Journal of regional anatomy and operative surgery, 2025, 34(1): 84-88.
TANG LI-QIANG, QU YUN. Research progress on TGF-β in peripheral nervous regeneration. [J]. Journal of regional anatomy and operative surgery, 2025, 34(1): 84-88. DOI： 10.11659/jjssx.01E024124.
摘要
周围神经损伤（PNI）是创伤患者中最常见的问题之一。PNI的治疗策略通常涉及手术修复、康复治疗和药物管理，但治疗效果仍可能达不到预期。在神经损伤后，施万细胞清除细胞碎片，释放促生长因子，提供导向支持，促使受损的神经突起重新生长并连接到目标组织。PNI后，转化生长因子β（TGF-β）被释放到损伤部位，能够诱导星形胶质细胞向A2表型的转化从而上调营养因子表达。同时，TGF-β能够启动施万细胞的一系列表型变化，调节免疫细胞，激活神经固有的生长能力，从而增强神经再生能力。TGF-β还可通过抑制炎症，促进血管生成，维持血-神经屏障的完整性，增强其通透性，为神经再生提供有益的微环境。本文回顾了TGF-β在外周神经再生中可能发挥的作用，并探讨了其中的潜在机制，为更好地治疗PNI提供新的线索。
Abstract
Peripheral nerve injury （PNI） is one of the most common issues among trauma patients.Treatment strategies for PNI typically involve surgical repair，rehabilitation therapy and medication management， but may still not achieve the expected therapeutic outcome.Following nerve injury，Schwann cells clear cellular debris，release growth-promoting factors and provide guidance support that promotes the regrowth of damaged nerve fibersand its reconnection to target tissues.The release of transforming growth factor beta （TGF-β） to the injury site after PNI can induce the transformation of astrocytes to an A2 phenotype，thereby upregulating the expression of neurotrophic factors.Meanwhile，TGF-β can initiate a series of phenotypic changes in Schwann cells，modulate immune cells，and activate the innate growth potential of neurons，thereby enhancing nerve regeneration potential.TGF-β can also promote angiogenesis，maintain the integrity of the blood-nerve barrier and enhance its permeability，thereby providing a beneficial microenvironment for nerve regeneration by inhibiting inflammation. This paper reviews the potential roles of TGF-β in peripheral nerve regeneration and investigates the underlying mechanisms，in order to provide new insights for better treatment of PNI.
关键词
周围神经再生TGF-β信号通路施万细胞沃勒变性巨噬细胞
Keywords
peripheral nerve regenerationTGF-β signaling pathwaySchwann cellsWallerian degenerationmacrophages
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