Short-term efficacy of 3D-printed artificial vertebral body combined with PEEK-Cage implantation in treatment of ossification of posterior longitudinal ligament of cervical spine
- JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY Vol. 34, Issue 4, Pages: 325-328(2025)
- 作者机构：
辽宁省人民医院骨五科，辽宁 沈阳 110000
- 作者简介：
- 基金信息：
DOI：10.11659/jjssx.01E024119
CLC： R681.5Received：25 January 2024，
Published：25 April 2025
- 稿件说明：
移动端阅览
孙绍铜,刘军,刘莛予等.3D打印人工椎体联合PEEK-Cage置入治疗颈椎后纵韧带骨化症短期疗效分析[J].局解手术学杂志,2025,34(04):325-328.
SUN Shao-tong,LIU Jun,LIU Ting-yu,et al.Short-term efficacy of 3D-printed artificial vertebral body combined with PEEK-Cage implantation in treatment of ossification of posterior longitudinal ligament of cervical spine[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(04):325-328.
孙绍铜,刘军,刘莛予等.3D打印人工椎体联合PEEK-Cage置入治疗颈椎后纵韧带骨化症短期疗效分析[J].局解手术学杂志,2025,34(04):325-328. DOI： 10.11659/jjssx.01E024119.
SUN Shao-tong,LIU Jun,LIU Ting-yu,et al.Short-term efficacy of 3D-printed artificial vertebral body combined with PEEK-Cage implantation in treatment of ossification of posterior longitudinal ligament of cervical spine[J].JOURNAL OF REGIONAL ANATOMY AND OPERATIVE SURGERY,2025,34(04):325-328. DOI： 10.11659/jjssx.01E024119.
摘要
目的
2
探讨颈椎前路3D打印人工椎体联合PEEK-Cage置入手术治疗颈椎后纵韧带骨化症（OPLL）的短期疗效。
方法
2
回顾性分析2022年9月至2023年6月在辽宁省人民医院骨五科接受颈椎前路3D打印人工椎体联合PEEK-Cage置入手术治疗的15例OPLL患者的临床资料。分析患者手术时间、术中失血量、术后引流量、卧床时间、住院时间及手术相关并发症情况。统计患者术前、术后3 d、术后1个月以及术后6个月日本骨科协会（JOA）评分、视觉模拟量表（VAS）评分。统计患者术前、术后3 d、术后1个月和术后6个月融合节段的Cobb角变化情况。
结果
2
15例患者均顺利完成手术，手术时间130~160 min，平均（148.68±10.04）min；术中出血量50~200 mL，平均（130.0±18.8）mL；术后引流量220~980 mL，平均（270.0±24.6）mL；卧床时间3~11 d，平均（3.6±2.8）d；住院时间7~16 d，平均（8.2±2.6）d。所有患者切口均Ⅰ期愈合，未出现感染。1例患者术中发生硬膜囊撕裂；4例患者术后出现吞咽困难；1例患者术后出现一侧肢体肌力减退；1例患者术后3 d颈椎手术切口内血肿形成。术后3 d、术后1个月和术后6个月，3例存在髓性症状伴上肢根性痛患者的Cobb角、VAS评分及JOA评分均较术前明显改善（
P
<
0.05），12例仅存髓性症状患者的Cobb角及JOA评分均较术前明显改善（
P
<
0.05）。
结论
2
颈椎前路3D打印人工椎体联合PEEK-Cage置入是治疗OPLL的一种有效方法，能在短期内显著缓解患者的疼痛，改善功能障碍，具有良好的稳定性和融合效果。
Abstract
Objective
2
To investigate the short-term efficacy of 3D-printed artificial vertebral body combined with PEEK-Cage implantation in anterior cervical surgery for ossification of the posterior longitudinal ligament of the cervical spine （OPLL）.
Methods
2
The clinical data of 15 patients with OPLL who underwent anterior cervical surgery with 3D-printed artificial vertebral body and PEEK-Cage implantation in the Fifth Department of Orthopaedics，Liaoning Provincial People's Hospital from September 2022 to June 2023 was retrospectively analyzed. The surgical time，intraoperative blood loss，postoperative drainage volume，bed rest time，hospital stay，and surgery-related complications of patients were analyzed. The Japanese Orthopaedic Association （JOA） score and visual analogue scale （VAS） score of patients were counted before surgery，3 days after surgery，1 month after surgery and 6 months after surgery. The changes of Cobb angle of fusion segment of patients were recorded before surgery，3 days after surgery，1 month after surgery and 6 months after surgery.
Results
2
All 15 patients successfully completed the surgery. The surgical time was 130 to 160 minutes，with an average of （148.68±10.04） minutes. The intraoperative blood loss was 50 to 200 mL，with an average of （130.0±18.8） mL. The postoperative drainage volume was 220 to 980 mL，with an average of （270.0±24.6） mL. The bed rest time was 3 to 11 days，with an average of （3.6±2.8） days. The hospital stay was 7 to 16 days，with an average of （8.2±2.6） days. All patients' incisions healed in the first stage，and no infection occurred. One patient suffered from dural sac tear during surgery； 4 patients had dysphagia after surgery； 1 patient suffered from muscle weakness of one limb after surgery； Hematoma formed in the incision of cervical spine in 1 patient 3 days after surgery. At 3 days，1 month，and 6 months after surgery，the Cobb angle，VAS score and JOA score of 3 patients with myeloid symptoms and upper limb root pain were significantly improved compared with those before surgery （
P
<
0.05），and the Cobb angle and JOA score of 12 patients with only myeloid symptoms were significantly improved compared with those before surgery （
P
<
0.05）.
Conclusion
2
3D-printed artificial vertebral body combined with PEEK-Cage implantation in anterior cervical surgery is an effective method for the treatment of OPLL，which can significantly relieve patients' pain and improve their dysfunction in a short time，with good stability and fusion effect.
关键词
Keywords
references
Boody BS ， Lendner M ， Vaccaro AR . Ossification of the posterior longitudinal ligament in the cervical spine：a review ［J］. Int Orthop ， 2019 ， 43 （ 4 ）： 797 - 805 . doi： 10.1007/s00264-018-4106-5 http://dx.doi.org/10.1007/s00264-018-4106-5 .
Head J ， Rymarczuk G ， Stricsek G ， et al . Ossification of the posterior lngitudinal ligament：surgical approaches and associated complications ［J］. Neurospine ， 2019 ， 16 （ 3 ）： 517 - 529 . doi： 10.14245/ns.1938 222.111 http://dx.doi.org/10.14245/ns.1938222.111 .
Nie W ， Gu F ， Wang Z ， et al . Preliminary application of three-dimension printing technology in surgical management of bicondylar tibial plateau fractures ［J］. Injury ， 2019 ， 50 （ 2 ）： 476 - 483 . doi： 10.1016/j.injury. 2018.12.019 http://dx.doi.org/10.1016/j.injury.2018.12.019 .
Shah FA ， Snis A ， Matic A ， et al . 3D printed Ti6Al4V implant surface promotes bone maturation and retains a higher density of less aged osteocytes at the bone-implant interface ［J］. Acta Biomater ， 2016 ， 30 ： 357 - 367 . doi： 10.1016/j.actbio.2015.11.013 http://dx.doi.org/10.1016/j.actbio.2015.11.013 .
Godlewski B ， Dominiak M . Advantages and disadvantages of the use of various types of interbody implants in cervical spine surgery.Critical review of the literature ［J］. Ortop Traumatol Rehabil ， 2020 ， 22 （ 4 ）： 213 - 220 . doi： 10.5604/01.3001.0014.3457 http://dx.doi.org/10.5604/01.3001.0014.3457 .
Li M ， Bai J ， Tao H ， et al . Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy ［J］. Bioact Mater ， 2021 ， 18 ： 309 - 324 . doi： 10.1016/j.bioactmat.2021.07.002 http://dx.doi.org/10.1016/j.bioactmat.2021.07.002 .
Odate S ， Shikata J ， Soeda T ， et al . Surgical results and complications of anterior decompression and fusion as a revision surgery after initial posterior surgery for cervical myelopathy due to ossification of the posterior longitudinal ligament ［J］. J Neurosurg Spine ， 2017 ， 26 （ 4 ）： 466 - 473 . doi： 10.3171/2016.9.SPINE16430 http://dx.doi.org/10.3171/2016.9.SPINE16430 .
Wang L ， Jiang Y ， Li M ， et al . Radiological characteristics and clinical outcome of ossification of posterior longitudinal ligament involving C 2 after posterior laminoplasty and instrumented fusion surgery ［J］. Spine （Phila Pa 1976） ， 2019 ， 44 （ 3 ）： E150 - E156 . doi： 10.1097/BRS.0000 000000002807 http://dx.doi.org/10.1097/BRS.0000000000002807 .
Chachan S ， Kasat NS ， Keng PTL . Cervical myelopathy secondary to combined ossification of ligamentum flavum and posterior longitudinal ligament-a case report ［J］. Int J Spine Surg ， 2018 ， 12 （ 2 ）： 121 - 125 . doi： 10.14444/5018 http://dx.doi.org/10.14444/5018 .
程军 ， 陈建 ， 谢鲤钟 ， 等 . 3D打印钛合金骨小梁人工椎体治疗颈椎后纵韧带骨化症 ［J］. 中国修复重建外科杂志 ， 2024 ， 38 （ 5 ）： 535 - 541 . doi： 10.7507/1002-1892.202403003 http://dx.doi.org/10.7507/1002-1892.202403003 .
Daniels AH ， McDonald CL ， Basques BA ， et al . Ossified ligamentum flavum：epidemiology，treatment，and outcomes ［J］. J Am Acad Orthop Surg ， 2022 ， 30 （ 12 ）： e842 - e851 . doi： 10.5435/JAAOS-D-21-01253 http://dx.doi.org/10.5435/JAAOS-D-21-01253 .
Liu J ， Hai Y ， Kang N ， et al . Risk factors and preventative measures of early and persistent dysphagia after anterior cervical spine surgery：a systematic review ［J］. Eur Spine J ， 2018 ， 27 （ 6 ）： 1209 - 1218 . doi： 10.1007/s00586-017-5311-4 http://dx.doi.org/10.1007/s00586-017-5311-4 .
Park JI ， Cho DC ， Kim KT ， et al . Anterior cervical discectomy and fusion using a stand-alone polyetheretherketone cage packed with local autobone：assessment of bone fusion and subsidence ［J］. J Korean Neurosurg Soc ， 2013 ， 54 （ 3 ）： 189 - 193 . doi： 10.3340/jkns. 2013.54.3.189 http://dx.doi.org/10.3340/jkns.2013.54.3.189 .
Odate S ， Shikata J ， Yamamura S ， et al . Extremely wide and asymmetric anterior decompression causes postoperative C 5 palsy：an analysis of 32 patients with postoperative C 5 palsy after anterior cervical decompression and fusion ［J］. Spine （Phila Pa 1976） ， 2013 ， 38 （ 25 ）： 2184 - 2189 . doi： 10.1097/BRS.0000000000000019 http://dx.doi.org/10.1097/BRS.0000000000000019 .
Mitchell BD ， Verla T ， Reddy D ， et al . Reliable intraoperative repair nuances of cerebrospinal fluid leak in anterior cervical spine surgery and review of the literature ［J］. World Neurosurg ， 2016 ， 88 ： 252 - 259 . doi： 10.1016/j.wneu.2016.01.014 http://dx.doi.org/10.1016/j.wneu.2016.01.014 .
Chu L ， Yang JS ， Yu KX ， et al . Usage ofbone wax tofacilitate percutaneous endoscopic cervical discectomy via anterior transcorporeal approach for cervical intervertebral disc herniation ［J］. World Neurosurg ， 2018 ， 118 ： 102 - 108 . doi： 10.1016/j.wneu.2018. 07.070 http://dx.doi.org/10.1016/j.wneu.2018.07.070 .
Cheng H ， Luo G ， Xu D ， et al . Comparison of radiological and clinical outcomes of 3D-printed artificial vertebral body with Titanium mesh cage in single-level anterior cervical corpectomy and fusion：a meta-analysis ［J］. Front Surg ， 2023 ， 9 ： 1077551 . doi： 10.3389/fsurg. 2022.1077551 http://dx.doi.org/10.3389/fsurg.2022.1077551 .
Kumar N ， Ramakrishnan SA ， Lopez KG ， et al . Can Polyether ether ketone dethrone titanium as the choice implant material for metastatic spine tumor surgery？ ［J］， World Neurosurg ， 2021 ， 148 ： 94 - 109 . doi： 10.1016/j.wneu.2021.01.059 http://dx.doi.org/10.1016/j.wneu.2021.01.059 .
0
Views
0
下载量
0
CSCD
- L-PDFDownload
- WORDDownload
- Meta-XMLDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
