Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence
- Burns & Trauma Vol. 8, Issue 1, (2020)
- 作者机构：
Division of Plastic and Reconstructive Surgery
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkz003
CLC：Published：2020，
Published Online：27 January 2020，
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Eri Shirakami, Sho Yamakawa, Kenji Hayashida, Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence, Burns & Trauma, Volume 8, 2020, tkz003, https://doi.org/10.1093/burnst/tkz003
摘要
Abstract
Once scar tissues mature
it is impossible for the surrounding tissue to regenerate normal dermal tissue. Therefore
it is essential to understand the fundamental mechanisms and establish effective strategies to inhibit aberrant scar formation. Hypertrophic scar formation is considered a result of the imbalance between extracellular matrix synthesis and degradation during wound healing. However
the underlying mechanisms of hypertrophic scar development are poorly understood. The purpose of this review was to outline the management in the early stage after wound healing to prevent hypertrophic scar formation
focusing on strategies excluding therapeutic agents of internal use. Treatment aimed at molecular targets
including cytokines
will be future options to prevent and treat hypertrophic scars. More basic studies and clinical trials
including combination therapy
are required to investigate the mechanisms and prevent hypertrophic scar formation.
关键词
Keywords
Hypertrophic scarTherapyInterventionCytokines
references
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