Autophagy-mediated regulation of neutrophils and clinical applications
- Burns & Trauma Vol. 8, Issue 1, (2020)
- 作者机构：
Department of Burns and Plastic Surgery
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkz001
CLC：Published：2020，
Published Online：16 January 2020，
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Yao Yu, Bingwei Sun, Autophagy-mediated regulation of neutrophils and clinical applications, Burns & Trauma, Volume 8, 2020, tkz001, https://doi.org/10.1093/burnst/tkz001
摘要
Abstract
Autophagy
an adaptive catabolic process
plays a cytoprotective role in enabling cellular homeostasis in the innate and adaptive immune systems. Neutrophils
the most abundant immune cells in circulation
are professional killers that orchestrate a series of events during acute inflammation. The recent literature indicates that autophagy has important roles in regulating neutrophil functions
including differentiation
degranulation
metabolism and neutrophil extracellular trap formation
that dictate neutrophil fate. It is also becoming increasingly clear that autophagy regulation is critical for neutrophils to exert their immunological activity. However
evidence regarding the systematic communication between neutrophils and autophagy is insufficient. Here
we provide an updated overview of the function of autophagy as a regulator of neutrophils and discuss its clinical relevance to provide novel insight into potentially relevant treatment strategies.
关键词
Keywords
AutophagyNeutrophilInnate immunityNETsClinical applicationNeutrophil extracellular trap
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