Acne-induced pathological scars: pathophysiology and current treatments

Wanyu Xu; Dorsa Gholamali Sinaki; Yuchen Tang; Yunsheng Chen; Yixin Zhang; Zheng Zhang

doi:10.1093/burnst/tkad060

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Acne-induced pathological scars: pathophysiology and current treatments

更新时间：2024-04-19

- Acne-induced pathological scars: pathophysiology and current treatments
- Burns & Trauma Vol. 12, Issue 1, (2024)
- 作者机构：
  
  1. Department of Plastic and Reconstructive Surgery
  2. Shanghai Jiao Tong University
  3. Department of Burns and Plastic Surgery
  4. Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkad060
  CLC：
- Published：2024，
  
  Published Online：5 April 2024，
扫描看全文
Wanyu Xu, Dorsa Gholamali Sinaki, Yuchen Tang, Yunsheng Chen, Yixin Zhang, Zheng Zhang, Acne-induced pathological scars: pathophysiology and current treatments, Burns & Trauma, Volume 12, 2024, tkad060, https://doi.org/10.1093/burnst/tkad060
DOI：

Wanyu Xu, Dorsa Gholamali Sinaki, Yuchen Tang, Yunsheng Chen, Yixin Zhang, Zheng Zhang, Acne-induced pathological scars: pathophysiology and current treatments, Burns & Trauma, Volume 12, 2024, tkad060, https://doi.org/10.1093/burnst/tkad060 DOI：

摘要

Abstract

Acne is a common chronic inflammatory dermatosis that can lead to pathological scars (PSs

divided into hypertrophic scars and keloids). These kinds of abnormal scars seriously reduce the quality of life of patients. However

their mechanism is still unclear

resulting in difficult clinical prevention

unstable treatment effects and a high risk of recurrence. Available evidence supports inflammatory changes caused by infection as one of the keys to abnormal proliferation of skin fibroblasts. In acne-induced PSs

increasing knowledge of the immunopathology indicates that inflammatory cells directly secrete growth factors to activate fibroblasts and release pro-inflammatory factors to promote the formation of PSs. T helper cells contribute to PSs via the secretion of interleukin (IL)-4 and IL-13

the pro-inflammatory factors; while regulatory T cells have anti-inflammatory effects

secrete IL-10 and prostaglandin E2

and suppress fibrosis production. Several treatments are available

but there is a lack of combination regimens to target different aspects of acne-induced PSs. Overall

this review indicates that the joint involvement of inflammatory response and fibrosis plays a crucial role in acne-induced PSs

and also analyzes the interaction of current treatments for acne and PS.

关键词

Keywords

Pathological scarsAcneInflammationFibrosisHypertrophic scarsKeloids

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