Broadening horizons: ferroptosis as a new target for traumatic brain injury

Ziqing Wei; Haihan Yu; Huijuan Zhao; Mingze Wei; Han Xing; Jinyan Pei; Yang Yang; Kaidi Ren

doi:10.1093/burnst/tkad051

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Broadening horizons: ferroptosis as a new target for traumatic brain injury

更新时间：2024-04-19

- Broadening horizons: ferroptosis as a new target for traumatic brain injury
- Burns & Trauma Vol. 12, Issue 1, (2024)
- 作者机构：
  
  1. Department of Neurology, The First Affiliated Hospital of Zhengzhou University
  2. Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University
  3. Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University
  4. Henan International Joint Laboratory of Thrombosis and Hemostasis
  5. Henan University of Science and Technology
  6. The Second Clinical Medical College, Harbin Medical University
  7. Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University
  8. Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University
  9. Quality Management Department
  10. Clinical Systems Biology Research Laboratories
  11. the First Affiliated Hospital of Zhengzhou University
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkad051
  CLC：
- Published：2024，
  
  Published Online：18 January 2024，
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Ziqing Wei, Haihan Yu, Huijuan Zhao, Mingze Wei, Han Xing, Jinyan Pei, Yang Yang, Kaidi Ren, Broadening horizons: ferroptosis as a new target for traumatic brain injury, Burns & Trauma, Volume 12, 2024, tkad051, https://doi.org/10.1093/burnst/tkad051
DOI：

Ziqing Wei, Haihan Yu, Huijuan Zhao, Mingze Wei, Han Xing, Jinyan Pei, Yang Yang, Kaidi Ren, Broadening horizons: ferroptosis as a new target for traumatic brain injury, Burns & Trauma, Volume 12, 2024, tkad051, https://doi.org/10.1093/burnst/tkad051 DOI：

摘要

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide

with ~50 million people experiencing TBI each year. Ferroptosis

a form of regulated cell death triggered by iron ion-catalyzed and reactive oxygen species-induced lipid peroxidation

has been identified as a potential contributor to traumatic central nervous system conditions

suggesting its involvement in the pathogenesis of TBI. Alterations in iron metabolism play a crucial role in secondary injury following TBI. This study aimed to explore the role of ferroptosis in TBI

focusing on iron metabolism disorders

lipid metabolism disorders and the regulatory axis of system Xc−/glutathione/glutathione peroxidase 4 in TBI. Additionally

we examined the involvement of ferroptosis in the chronic TBI stage. Based on these findings

we discuss potential therapeutic interventions targeting ferroptosis after TBI. In conclusion

this review provides novel insights into the pathology of TBI and proposes potential therapeutic targets.

关键词

Keywords

Traumatic brain injuryFerroptosisTherapeutic targetsLipid peroxidationReactive oxygen speciesMetabolismBlood-brain barrier

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