Metabolic reprogramming in skin wound healing
- Burns & Trauma Vol. 12, Issue 1, (2024)
- 作者机构：
1. Department of Pathology, Shengjing Hospital of China Medical University
2. Department of Stem Cells and Regenerative Medicine
3. China Medical University
4. Department of General Surgery, Shengjing Hospital of China Medical University
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkad047
CLC：Published：2024，
Published Online：2 January 2024，
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Zitong Wang, Feng Zhao, Chengcheng Xu, Qiqi Zhang, Haiyue Ren, Xing Huang, Cai He, Jiajie Ma, Zhe Wang, Metabolic reprogramming in skin wound healing, Burns & Trauma, Volume 12, 2024, tkad047, https://doi.org/10.1093/burnst/tkad047
摘要
Abstract
Metabolic reprogramming refers to the ability of a cell to alter its metabolism in response to different stimuli and forms of pressure. It helps cells resist external stress and provides them with new functions. Skin wound healing involves the metabolic reprogramming of nutrients
such as glucose
lipids
and amino acids
which play vital roles in the proliferation
differentiation
and migration of multiple cell types. During the glucose metabolic process in wounds
glucose transporters and key enzymes cause elevated metabolite levels. Glucose-mediated oxidative stress drives the proinflammatory response and promotes wound healing. Reprogramming lipid metabolism increases the number of fibroblasts and decreases the number of macrophages. It enhances local neovascularization and improves fibrin stability to promote extracellular matrix remodelling
accelerates wound healing
and reduces scar formation. Reprogramming amino acid metabolism affects wound re-epithelialization
collagen deposition
and angiogenesis. However
comprehensive reviews on the role of metabolic reprogramming in skin wound healing are lacking. Therefore
we have systematically reviewed the metabolic reprogramming of glucose
lipids
and amino acids during skin wound healing. Notably
we identified their targets with potential therapeutic value and elucidated their mechanisms of action.
关键词
Keywords
Metabolic reprogrammingWound healingskinMolecular mechanismTherapeutic potential
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