The impact of COVID-19 on clinical outcomes of burn patients

Elliot T Walters; Alen Palackic; Camila Franco-Mesa; Nikhil R Shah; Michael J Erickson; Steven E Wolf

doi:10.1093/burnst/tkad042

您当前的位置：

首页 >

文章列表页 >

The impact of COVID-19 on clinical outcomes of burn patients

更新时间：2024-02-04

- The impact of COVID-19 on clinical outcomes of burn patients
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
  
  1. Department of Surgery, University of Texas Medical Branch
  2. Division of Plastic
  3. Medical University of Graz
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkad042
  CLC：
- Published：2023，
  
  Published Online：5 December 2023，
扫描看全文
Elliot T Walters, Alen Palackic, Camila Franco-Mesa, Nikhil R Shah, Michael J Erickson, Steven E Wolf, The impact of COVID-19 on clinical outcomes of burn patients, Burns & Trauma, Volume 11, 2023, tkad042, https://doi.org/10.1093/burnst/tkad042
DOI：

Elliot T Walters, Alen Palackic, Camila Franco-Mesa, Nikhil R Shah, Michael J Erickson, Steven E Wolf, The impact of COVID-19 on clinical outcomes of burn patients, Burns & Trauma, Volume 11, 2023, tkad042, https://doi.org/10.1093/burnst/tkad042 DOI：

摘要

Abstract

BackgroundMultiple studies have shown the SARS-CoV-2 virus (COVID-19) to be associated with deleterious outcomes in a wide range of patients. The impact of COVID-19 has not been well investigated among burned patients. We suspect that patients will have worsened respiratory and thrombotic complications

ultimately leading to increased mortality. The objective of this study is to determine the impact a concurrent infection of COVID-19 has on clinical outcomes after a burn injury.MethodsThis is a retrospective

propensity matched

cohort study. We examined a de-identified database of electronic medical records of over 75 million patients across 75 health care associations in the United States for patients treated for thermal burns from 1 January 2020

to 31 July 2021

and those who also were diagnosed with COVID-19 infection within one day before or after injury based on International Classification of Disease

tenth revision (ICD-10) codes. Study participants included adults who were treated for a burn injury during the study period.ResultsWe included 736 patients with burn injury and concomitant COVID-19 infection matched to 736 patients with burn injury and no concurrent COVID-19 infection (total 1472 patients

mean age 36.3 ± 24.3). We found no significant increase in mortality observed for patients with concurrent COVID-19 (OR 1.203

95% CI 0.517–2.803; p = 0.6675). We did observe significant increase in infections (OR 3.537

95% CI 2.798–4.471; p = 0.0001)

thrombotic complications (OR 2.342

95% CI 1.351–4.058; p = 0.0018)

as was the incidence of hypertrophic scarring (OR 3.368

95% CI 2.326–4.877; p = 0.0001).ConclusionsWe observed that concurrent COVID-19 infection was associated with an increase in infections

thrombosis and hypertrophic scarring but no increase in mortality in our cohort of burn patients.

关键词

Keywords

COVID-19InfectionMortalityBurnThrombosisScarring

references

1.Wu Z, Zhang Q, Ye G, Zhang H, Heng BC, Fei Y, et al. Structural and physiological changes of the human body upon SARS-CoV-2 infection. J Zhejiang Univ Sci B. 2021;22:310–7. https://doi.org/10.1631/jzus.B2000523.

2.Iba T, Connors JM, Levy JH. The coagulopathy, endotheliopathy, and vasculitis of COVID-19. Inflamm Res. 2020;69:1181–9. https://doi.org/10.1007/s00011-020-01401-6.

3.Choudhary S, Sharma K, Silakari O. The interplay between inflammatory pathways and COVID-19: a critical review on pathogenesis and therapeutic options. Microb Pathog. 2021;150:104673. https://doi.org/10.1016/j.micpath.2020.104673.

4.Al-Benna S. Inflammatory and coagulative pathophysiology for the management of burn patients with COVID-19: systematic review of the evidence. Annals of Burns and Fire Disasters. 2021;34:3–9.

5.Andraska EA, Alabi O, Dorsey C, Erben Y, Velazquez G, Franco-Mesa C, et al. Health care disparities during the COVID-19 pandemic. Semin Vasc Surg. 2021;34:82–8. https://doi.org/10.1053/j.semvascsurg.2021.08.002.

6.Bhangu A, Nepogodiev D, Glasbey JC, Li E, Omar OM, Simoes JFF, et al. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. Lancet. 2020;396:27–38. https://doi.org/10.1016/S0140-6736(20)31182-X.

7.Lei S, Jiang F, Su W, Chen C, Chen J, Mei W, et al. Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection. EClinicalMedicine. 2020;21:100331. https://doi.org/10.1016/j.eclinm.2020.100331.

8.Codner JA, de Ayala R, Gayed RM, Lamphier CK, Mittal R. The impact of the COVID-19 pandemic on burn admissions at a major metropolitan burn Center. J Burn Care Res. 2021;42:1103–9. https://doi.org/10.1093/jbcr/irab106.

9.Chara A, Hodgman E, Ziegfeld S, Parrish C, Rhee D, Garcia AV. Predictors of follow-up compliance in Pediatric burn patients during the time of COVID. J Burn Care Res. 42:1097–102. https://doi.org/10.1093/jbcr/irab152.

10.Kruchevsky D, Arraf M, Levanon S, Capucha T, Ramon Y, Ullmann Y. Trends in burn injuries in northern Israel during the COVID-19 lockdown. J Burn Care Res. 2020;42:135–40. https://doi.org/10.1093/jbcr/iraa154.

11.Labò N, Ohnuki H, Tosato G. Vasculopathy and coagulopathy associated with SARS-CoV-2 infection. Cell. 2020;9:1583. https://doi.org/10.3390/cells9071583.

12.Anka AU, Tahir MI, Abubakar SD, Alsabbagh M, Zian Z, Hamedifar H, et al. Coronavirus disease 2019 (COVID-19): an overview of the immunopathology, serological diagnosis and management. Scand J Immunol. 2021;93:e12998. https://doi.org/10.1111/sji.12998.

13.Jeschke MG, Mlcak RP, Finnerty CC, Norbury WB, Gauglitz GG, Kulp GA, et al. Burn size determines the inflammatory and hypermetabolic response. Crit Care. 2007;11:R90. https://doi.org/10.1186/cc6102.

14.Pannucci CJ, Osborne NH, Wahl WL. Venous thromboembolism in thermally injured patients: analysis of the national burn repository. J Burn Care Res. 2011;32:6–12. https://doi.org/10.1097/BCR.0b013e318204b2ff.

15.Liu A, Minasian RA, Maniago E, Justin Gillenwater T, Garner WL, Yenikomshian HA. Venous thromboembolism chemoprophylaxis in burn patients: a literature review and single-institution experience. Journal of Burn Care & Research: official publication of the American Burn Association. 2021;42:18–22. https://doi.org/10.1093/jbcr/iraa143.

16.Harrington DT, Mozingo DW, Cancio L, Bird P, Jordan B, Goodwin CW. Thermally injured patients are at significant risk for thromboembolic complications. The Journal of Trauma: Injury, Infection, and Critical Care. 2001;50:495–9. https://doi.org/10.1097/00005373-200103000-00014.

17.Wilmore DW, Aulick LH, Mason D, Pruitt BA. Influence of the burn wound on local and systemic responses to injury. Ann Surg. 1977;186:444–58. https://doi.org/10.1097/00000658-197710000-00006.

18.Satahoo SS, Parikh PP, Naranjo D, Davis JS, Duncan RC, Pizano LR, et al. Are burn patients really at risk for thrombotic events? J Burn Care Res. 2015;36:100–4. https://doi.org/10.1097/BCR.0000000000000093.

19.Sikora S, Papp A. Venous thromboembolism in burn patients is not prevented by chemoprophylaxis. Burns. 2017;43:1330–4. https://doi.org/10.1016/j.burns.2017.03.014.

20.Leisman DE, Deutschman CS, Legrand M. Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation. Intensive Care Med. 2020;46:1105–8. https://doi.org/10.1007/s00134-020-06059-6.

21.Lachiewicz AM, Hauck CG, Weber DJ, Cairns BA, van Duin D. Bacterial infections after burn injuries: impact of multidrug resistance. Clin Infect Dis. 2017;65:2130–6. https://doi.org/10.1093/cid/cix682.

22.Lee HJ, Jang YJ. Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids. Int J Mol Sci. 2018;19. https://doi.org/10.3390/ijms19030711.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Length of hospital stay and mortality associated with burns from assault: a retrospective study with inverse probability weighting analysis

Red cell distribution width/albumin ratio and 90-day mortality after burn surgery

The prognostic nutritional index on postoperative day one is associated with one-year mortality after burn surgery in elderly patients

The pathogenesis and diagnosis of sepsis post burn injury

Heparin resistance in severe thermal injury: a prospective cohort study

Related Author

Ryo Yamamoto

Mitsunobu Toyosaki

Tomohiro Kurihara

Junichi Sasaki

Young Joo Seo

Jihion Yu

Jun-Young Park

Narea Lee

Related Institution

Department of Emergency and Critical Care Medicine

Department of Anesthesiology and Pain Medicine

Hallym University College of Medicine

University of Ulsan College of Medicine

Department of Anesthesiology and Pain Medicine, National Medical Center

⁰