Tailored biomedical materials for wound healing
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
1. Clinical laboratory, Affiliated Aoyang Hospital of Jiangsu University
2. Jiangsu University
3. Medical School of Southeast University
4. Department of Orthopaedics, Affiliated Aoyang Hospital of Jiangsu University
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkad040
CLC：Published：2023，
Published Online：26 October 2023，
扫 描 看 全 文
Wenhui Liu, Lihua Zu, Shanzheng Wang, Jingyao Li, Xiaoyuan Fei, Meng Geng, Chunlei Zhu, Hui Shi, Tailored biomedical materials for wound healing, Burns & Trauma, Volume 11, 2023, tkad040, https://doi.org/10.1093/burnst/tkad040
摘要
Abstract
Wound healing is a long-term
multi-stage biological process that mainly includes haemostatic
inflammatory
proliferative and tissue remodelling phases. Controlling infection and inflammation and promoting tissue regeneration can contribute well to wound healing. Smart biomaterials offer significant advantages in wound healing because of their ability to control wound healing in time and space. Understanding how biomaterials are designed for different stages of wound healing will facilitate future personalized material tailoring for different wounds
making them beneficial for wound therapy. This review summarizes the design approaches of biomaterials in the field of anti-inflammatory
antimicrobial and tissue regeneration
highlights the advanced precise control achieved by biomaterials in different stages of wound healing and outlines the clinical and practical applications of biomaterials in wound healing.
关键词
Keywords
Wound healingBiomedical materialsAdvanced materialsTissue regenerationInflammationRegenerationAnti-bacterialCutaneous injury
references
1.Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med. 2011;17:113–25.
2.Berman B, Maderal AD, Raphael BA. Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg. 2017;43:S3–18.
3.Chen TY, Wen TK, Dai NT, Hsu SH. Cryogel/hydrogel biomaterials and acupuncture combined to promote diabetic skin wound healing through immunomodulation. Biomaterials. 2021;269:120608.
4.Niu Y, Li Q, Ding Y, Dong L, Wang C. Engineered delivery strategies for enhanced control of growth factor activities in wound healing. Adv Drug Deliv Rev. 2019;146:190–208.
5.Nussbaum SR, Carter MJ, Fife CE, DaVanzo J, Haught R, Nusgart M, et al. An economic evaluation of the impact, cost, and Medicare policy implications of chronic nonhealing wounds. Value Health. 2018;21:27–32.
6.Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, et al. Regeneration of fat cells from myofibroblasts during wound healing. Science. 2017;355:748–52.
7.Qi X, Huang Y, You S, Xiang Y, Cai E, Mao R, et al. Engineering robust ag-decorated Polydopamine Nano-Photothermal platforms to combat bacterial infection and prompt wound healing. Adv Sci (Weinh). 2022;9:e2106015.
8.Qi X, Tong X, You S, Mao R, Cai E, Pan W, et al. Mild hyperthermia-assisted ROS scavenging hydrogels achieve diabetic wound healing. ACS Macro Lett. 2022;11:861–7.
9.Xiang Y, Qi X, Cai E, Zhang C, Wang J, Lan Y, et al. Highly efficient bacteria-infected diabetic wound healing employing a melanin-reinforced biopolymer hydrogel. Chem Eng J. 2023;460:141852.
10.You S, Huang Y, Mao R, Xiang Y, Cai E, Chen Y, et al. Together is better: poly(tannic acid) nanorods functionalized polysaccharide hydrogels for diabetic wound healing. Ind Crop Prod. 2022;186:115273.
11.Bhardwaj N, Chouhan D, Mandal BB. Tissue engineered skin and wound healing: current strategies and future directions. Curr Pharm Des. 2017;23:3455–82.
12.Kharaziha M, Baidya A, Annabi N. Rational Design of Immunomodulatory Hydrogels for chronic wound healing. Adv Mater. 2021;33:e2100176.
13.Xie Z, Aphale NV, Kadapure TD, Wadajkar AS, Orr S, Gyawali D, et al. Design of antimicrobial peptides conjugated biodegradable citric acid derived hydrogels for wound healing. J Biomed Mater Res A. 2015;103:3907–18.
14.Marin E, Boschetto F, Pezzotti G. Biomaterials and biocompatibility: An historical overview. J Biomed Mater Res A. 2020;108:1617–33.
15.Murariu M, Dubois P. PLA composites: from production to properties. Adv Drug Deliv Rev. 2016;107:17–46.
16.Guan T, Li J, Chen C, Liu Y. Self-assembling peptide-based hydrogels for wound tissue repair. Adv Sci (Weinh). 2022;9:2104165.
17.Hao F, Wang L, Chen B, Qiu L, Nie J, Ma G. Bifunctional smart hydrogel dressing with strain sensitivity and NIR-responsive performance. ACS Appl Mater Interfaces. 2021;13:46938–50.
18.Harding KG, Morris HL, Patel GK. Science, medicine and the future: healing chronic wounds. BMJ. 2002;324:160–3.
19.Liu H, Li Z, Che S, Feng Y, Guan L, Yang X, et al. A smart hydrogel patch with high transparency, adhesiveness and hemostasis for all-round treatment and glucose monitoring of diabetic foot ulcers. J Mater Chem B. 2022;10:5804–17.
20.Breitkreutz D, Koxholt I, Thiemann K, Nischt R. Skin basement membrane: the foundation of epidermal integrity--BM functions and diverse roles of bridging molecules nidogen and perlecan. Biomed Res Int. 2013;2013:1–16.
21.Breitkreutz D, Koxholt I, Thiemann K, Nischt R. Skin basement membrane: the foundation of epidermal integrity--BM functions and diverse roles of bridging molecules nidogen and perlecan. Biomed Res Int. 2013;2013:1–16.
22.Breitkreutz D, Koxholt I, Thiemann K, Nischt R. Skin basement membrane: the foundation of epidermal integrity--BM functions and diverse roles of bridging molecules nidogen and perlecan. Biomed Res Int. 2013;2013:1–16.
23.Lee J, Byun H, Madhurakkat Perikamana SK, Lee S, Shin H. Current advances in immunomodulatory biomaterials for bone regeneration. Adv Healthc Mater. 2019;4:e1801106.
24.Matsukawa M, Greenberg EP. Putative exopolysaccharide synthesis genes influence Pseudomonas aeruginosa biofilm development. J Bacteriol. 2004;186:4449–56.
25.Serra R, Grande R, Buffone G, Molinari V, Perri P, Perri A, et al. Extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines. Int Wound J. 2016;13:53–8.
26.Leach DG, Young S, Hartgerink JD. Advances in immunotherapy delivery from implantable and injectable biomaterials. Acta Biomater. 2019;88:15–31.
27.Zhang X, Kim TH, Thauland TJ, Li H, Majedi FS, Ly C, et al. Unraveling the mechanobiology of immune cells. Curr Opin Biotechnol. 2020;66:236–45.
28.Biswal T, BadJena SK, Pradhan D. Sustainable biomaterials and their applications: a short review. Materials Today: Proceedings. 2020;30:274–82.
29.Cao D, Ding J. Recent advances in regenerative biomaterials. Regen Biomater. 2022;9:rbac098.
30.Niinomi M. Metallic biomaterials. J Artif Organs. 2008;11:105–10.
31.Pandey A, Awasthi A, Saxena KK. Metallic implants with properties and latest production techniques: a review. Advances in Materials and Processing Technologies. 2020;6:405–40.
32.Fu X, Zhou X, Liu P, Chen H, Xiao Z, Yuan B, et al. The optimized preparation of HA/L-TiO(2)/D-TiO(2) composite coating on porous titanium and its effect on the behavior osteoblasts. Regen Biomater. 2020;7:505–14.
33.Puckett SD, Taylor E, Raimondo T, Webster TJ. The relationship between the nanostructure of titanium surfaces and bacterial attachment. Biomaterials. 2010;31:706–13.
34.Souza JCM, Sordi MB, Kanazawa M, Ravindran S, Henriques B, Silva FS, et al. Nano-scale modification of titanium implant surfaces to enhance osseointegration. Acta Biomater. 2019;94:112–31.
35.Verma RP. Titanium based biomaterial for bone implants: a mini review. Materials Today: Proceedings. 2020;26:3148–51.
36.Wang R, Shi M, Xu F, Qiu Y, Zhang P, Shen K, et al. Graphdiyne-modified TiO(2) nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection. Nat Commun. 2020;11:4465.
37.Yuan Z, He Y, Lin C, Liu P, Cai K. Antibacterial surface design of biomedical titanium materials for orthopedic applications. Journal of Materials Science & Technology. 2021;78:51–67.
38.Li R, Xu Z, Jiang Q, Zheng Y, Chen Z, Chen X. Characterization and biological evaluation of a novel silver nanoparticle-loaded collagen-chitosan dressing. Regen Biomater. 2020;7:371–80.
39.Peng F, Cheng S, Zhang R, Li M, Zhou J, Wang D, et al. Zn-contained mussel-inspired film on mg alloy for inhibiting bacterial infection and promoting bone regeneration. Regen Biomater. 2021;8:rbaa044.
40.Xu X, Lu Y, Zhou L, He M, Zhuo J, Zhong Q, et al. Tuning osteoporotic macrophage responses to favour regeneration by cu-bearing titanium alloy in Porphyromonas gingivalis lipopolysaccharide-induced microenvironments. Regen Biomater. 2021;8:rbaa045.
41.Yang J, Huang Y, Dai J, Shi X, Zheng Y. A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model. Regen Biomater. 2021;8:rbab037.
42.Li H, Wang W, Chang J. Calcium silicate enhances immunosuppressive function of MSCs to indirectly modulate the polarization of macrophages. Regen Biomater. 2021;8:rbab056.
43.Luo Q, Li X, Zhong W, Cao W, Zhu M, Wu A, et al. Dicalcium silicate-induced mitochondrial dysfunction and autophagy-mediated macrophagic inflammation promotes osteogenic differentiation of BMSCs. Regen Biomater. 2022;9:rbab075.
44.Subedi MM. Ceramics and its importance. The Himalayan Physics. 2013;4:80–2.
45.Hoppe A, Güldal NS, Boccaccini AR. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials. 2011;32:2757–74.
46.Huang D, Zhao F, Gao W, Chen X, Guo Z, Zhang W. Strontium-substituted sub-micron bioactive glasses inhibit ostoclastogenesis through suppression of RANKL-induced signaling pathway. Regen Biomater. 2020;7:303–11.
47.Correa S, Grosskopf AK, Lopez Hernandez H, Chan D, Yu AC, Stapleton LM, et al. Translational applications of hydrogels. Chem Rev. 2021;121:11385–457.
48.Ghobril C, Grinstaff MW. The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial. Chem Soc Rev. 2015;44:1820–35.
49.Cao C, Yang N, Zhao Y, Yang D, Hu Y, Yang D, et al. Biodegradable hydrogel with thermo-response and hemostatic effect for photothermal enhanced anti-infective therapy. Nano Today. 2021;39:101165.
50.Chen X, Wo F, Jin Y, Tan J, Lai Y, Wu J. Drug-porous silicon dual luminescent system for monitoring and inhibition of wound infection. ACS Nano. 2017;11:7938–49.
51.Liu T, Xiao B, Xiang F, Tan J, Chen Z, Zhang X, et al. Ultrasmall copper-based nanoparticles for reactive oxygen species scavenging and alleviation of inflammation related diseases. Nat Commun. 2020;11:2788.
52.Shan J, Li X, Yang K, Xiu W, Wen Q, Zhang Y, et al. Efficient bacteria killing by cu(2)WS(4) nanocrystals with enzyme-like properties and bacteria-binding ability. ACS Nano. 2019;13:13797–808.
53.Shi H, Xu X, Zhang B, Xu J, Pan Z, Gong A, et al. 3,3'-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing. Theranostics. 2017;7:1674–88.
54.Zhang B, Wang M, Gong A, Zhang X, Wu X, Zhu Y, et al. HucMSC-exosome mediated-Wnt4 Signaling is required for cutaneous wound healing. Stem Cells. 2015;33:2158–68.
55.Bakshi PS, Selvakumar D, Kadirvelu K, Kumar NS. Chitosan as an environment friendly biomaterial - a review on recent modifications and applications. Int J Biol Macromol. 2020;150:1072–83.
56.Chen C, Xu HH, Liu XY, Zhang YS, Zhong L, Wang YW, et al. 3D printed collagen/silk fibroin scaffolds carrying the secretome of human umbilical mesenchymal stem cells ameliorated neurological dysfunction after spinal cord injury in rats. Regen Biomater. 2022;9:rbac014.
57.Liu Y, Fan J, Lv M, She K, Sun J, Lu Q, et al. Photocrosslinking silver nanoparticles-aloe vera-silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds. Regen Biomater. 2021;8:rbab048.
58.Trombino S, Servidio C, Curcio F, Cassano R. Strategies for hyaluronic acid-based hydrogel Design in Drug Delivery. Pharmaceutics. 2019;11:8.
59.Varaprasad K, Jayaramudu T, Kanikireddy V, Toro C, Sadiku ER. Alginate-based composite materials for wound dressing application:a mini review. Carbohydr Polym. 2020;236:116025.
60.Wang Z, Ke M, He L, Dong Q, Liang X, Rao J, et al. Biocompatible and antibacterial soy protein isolate/quaternized chitosan composite sponges for acute upper gastrointestinal hemostasis. Regen Biomater. 2021;8:rbab034.
61.Alves NM, Pashkuleva I, Reis RL, Mano JF. Controlling cell behavior through the design of polymer surfaces. Small. 2010;6:2208–20.
62.Zhang Z, Lai Y, Yu L, Ding J. Effects of immobilizing sites of RGD peptides in amphiphilic block copolymers on efficacy of cell adhesion. Biomaterials. 2010;31:7873–82.
63.Mahmood A, Patel D, Hickson B, DesRochers J, Hu X. Recent progress in biopolymer-based hydrogel materials for biomedical applications. Int J Mol Sci. 2022;23:1415.
64.Ali Zahid A, Chakraborty A, Shamiya Y, Ravi SP, Paul A. Leveraging the advancements in functional biomaterials and scaffold fabrication technologies for chronic wound healing applications. Mater Horiz. 2022;9:1850–65.
65.Chouhan D, Mandal BB. Silk biomaterials in wound healing and skin regeneration therapeutics: from bench to bedside. Acta Biomater. 2020;103:24–51.
66.Gao YX, Wang LF, Ba T, Zou XF, Cao SJ, Li JL, et al. Research advances of natural biomaterials in promoting wound repair[J]. Chin J Burns Wounds. 2023;39:481–6.
67.Farahani M, Shafiee A. Wound healing: from passive to smart dressings. Adv Healthc Mater. 2021;10:e2100477.
68.Han C, Nie Y, Lian H, Liu R, He F, Huang H, et al. Acute inflammation stimulates a regenerative response in the neonatal mouse heart. Cell Res. 2015;25:1137–51.
69.Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454:428–35.
70.Boniakowski AE, Kimball AS, Jacobs BN, Kunkel SL, Gallagher KA. Macrophage-mediated inflammation in normal and diabetic wound healing. J Immunol. 2017;199:17–24.
71.Mirza R, DiPietro LA, Koh TJ. Selective and specific macrophage ablation is detrimental to wound healing in mice. Am J Pathol. 2009;175:2454–62.
72.Soehnlein O, Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol. 2010;10:427–39.
73.Weavers H, Liepe J, Sim A, Wood W, Martin P, Stumpf MPH. Systems analysis of the dynamic inflammatory response to tissue damage reveals spatiotemporal properties of the wound attractant gradient. Curr Biol. 2016;26:1975–89.
74.Stejskalová A, Almquist BD. Using biomaterials to rewire the process of wound repair. Biomater Sci. 2017;5:1421–34.
75.Wu J, Zhu J, Wu Q, An Y, Wang K, Xuan T, et al. Mussel-inspired surface immobilization of heparin on magnetic nanoparticles for enhanced wound repair via sustained release of a growth factor and M2 macrophage polarization. ACS Appl Mater Interfaces. 2021;13:2230–44.
76.Qian Y, Zheng Y, Jin J, Wu X, Xu K, Dai M, et al. Immunoregulation in diabetic wound repair with a Photoenhanced Glycyrrhizic acid hydrogel scaffold. Adv Mater. 2022;34:e2200521.
77.Zhang S, Liu Y, Zhang X, Zhu D, Qi X, Cao X, et al. Prostaglandin E(2) hydrogel improves cutaneous wound healing via M2 macrophages polarization. Theranostics. 2018;8:5348–61.
78.Chen C, Liu Y, Wang H, Chen G, Wu X, Ren J, et al. Multifunctional chitosan inverse opal particles for wound healing. ACS Nano. 2018;12:10493–500.
79.Li X, Cho B, Martin R, Seu M, Zhang C, Zhou Z, et al. Nanofiber-hydrogel composite-mediated angiogenesis for soft tissue reconstruction. Sci Transl Med. 2019;11:490.
80.Zhang F, Hu C, Kong Q, Luo R, Wang Y. Peptide−/drug-directed self-assembly of hybrid polyurethane hydrogels for wound healing. ACS Appl Mater Interfaces. 2019;11:37147–55.
81.Zujian F, Su Q, Zhang C, Huang P, Song H, Dong A, et al. Bioinspired Nanofibrous Glycopeptide hydrogel dressing for accelerating wound healing: a cytokine-free, M2-type macrophage polarization approach. Adv Funct Mater. 2020;30:2006454.
82.Sridharan R, Cameron A, Kelly D, Kearney C, O’Brien F. Biomaterial based modulation of macrophage polarization: a review and suggested design principles. Mater Today. 2015;18:313–25.
83.Almeida CR, Serra T, Oliveira MI, Planell JA, Barbosa MA, Navarro M. Impact of 3-D printed PLA- and chitosan-based scaffolds on human monocyte/macrophage responses: unraveling the effect of 3-D structures on inflammation. Acta Biomater. 2014;10:613–22.
84.Brodbeck WG, Patel J, Voskerician G, Christenson E, Shive MS, Nakayama Y, et al. Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo. Proc Natl Acad Sci U S A. 2002;99:10287–92.
85.Sheng L, Zhang Z, Zhang Y, Wang E, Ma B, Xu Q, et al. A novel "hot spring"-mimetic hydrogel with excellent angiogenic properties for chronic wound healing. Biomaterials. 2021;264:120414.
86.Xu Z, Han S, Gu Z, Wu J. Advances and impact of antioxidant hydrogel in chronic wound healing. Adv Healthc Mater. 2020;9:1901502.
87.Ye K, Kuang H, You Z, Morsi Y, Mo X. Electrospun nanofibers for tissue engineering with drug loading and release. Pharmaceutics. 2019;11:4.
88.Ye S, Jiang L, Wu J, Su C, Huang C, Liu X, et al. Flexible amoxicillin-grafted bacterial cellulose sponges for wound dressing: in vitro and in vivo evaluation. ACS Appl Mater Interfaces. 2018;10:5862–70.
89.Schuren J, Becker A, Sibbald RG. A liquid film-forming acrylate for peri-wound protection: a systematic review and meta-analysis (3M Cavilon no-sting barrier film). Int Wound J. 2005;2:230–8.
90.Zhang K, Jiao X, Zhou L, Wang J, Wang C, Qin Y, et al. Nanofibrous composite aerogel with multi-bioactive and fluid gating characteristics for promoting diabetic wound healing. Biomaterials. 2021;276:121040.
91.Geering B, Simon HU. Peculiarities of cell death mechanisms in neutrophils. Cell Death Differ. 2011;18:1457–69.
92.O'Donnell JA, Kennedy CL, Pellegrini M, Nowell CJ, Zhang JG, O'Reilly LA, et al. Fas regulates neutrophil lifespan during viral and bacterial infection. J Leukoc Biol. 2015;97:321–6.
93.Liu X, Dou G, Li Z, Wang X, Jin R, Liu Y, et al. Hybrid biomaterial initiates refractory wound healing via inducing transiently heightened inflammatory responses. Adv Sci (Weinh). 2022;9:2105650.
94.Peng Y, He D, Ge X, Lu Y, Chai Y, Zhang Y, et al. Construction of heparin-based hydrogel incorporated with Cu5.4O ultrasmall nanozymes for wound healing and inflammation inhibition. Bioact Mater. 2021;6:3109–24.
95.Klar AS, Zimoch J, Biedermann T. Skin tissue engineering: application of adipose-derived stem cells. Biomed Res Int. 2017;2017:1–12.
96.Fougère B, Boulanger E, Nourhashémi F, Guyonnet S, Cesari M. Chronic inflammation: accelerator of biological aging. J Gerontol A Biol Sci Med Sci. 2017;72:1218–25.
97.Mandla S, Davenport Huyer L, Radisic M. Review: multimodal bioactive material approaches for wound healing. APL Bioeng. 2018;2:021503.
98.Simões D, Miguel SP, Ribeiro MP, Coutinho P, Mendonça AG, Correia IJ. Recent advances on antimicrobial wound dressing: a review. Eur J Pharm Biopharm. 2018;127:130–41.
99.Jaggessar A, Shahali H, Mathew A, Yarlagadda P. Bio-mimicking nano and micro-structured surface fabrication for antibacterial properties in medical implants. J Nanobiotechnology. 2017;15:64.
100.Zhao X, Pei D, Yang Y, Xu K, Yu J, Zhang Y, et al. Green tea derivative driven smart hydrogels with desired functions for chronic diabetic wound treatment. Adv Funct Mater. 2021;31:2009442.1-14.
101.Norouzi M, Boroujeni SM, Omidvarkordshouli N, Soleimani M. Advances in skin regeneration: application of electrospun scaffolds. Adv Healthc Mater. 2015;4:1114–33.
102.Dale AP, Saeed K. Novel negative pressure wound therapy with instillation and the management of diabetic foot infections. Curr Opin Infect Dis. 2015;2:151–7.
103.Siddiqui AR, Bernstein JM. Chronic wound infection: facts and controversies. Clin Dermatol. 2010;5:519–26.
104.Zhang W, Chen L, Chen J, Wang L, Gui X, Ran J, et al. Silk fibroin biomaterial shows safe and effective wound healing in animal models and a randomized controlled clinical trial. Adv Healthc Mater. 2017;6:10.
105.Kaya S, Cresswell M, Boccaccini AR. Mesoporous silica-based bioactive glasses for antibiotic-free antibacterial applications. Mater Sci Eng C Mater Biol Appl. 2018;83:99–107.
106.Liang Y, Liang Y, Zhang H, Guo B. Antibacterial biomaterials for skin wound dressing. Asian J Pharm Sci. 2022;17:353–84.
107.Martinotti S, Ranzato E, Honey RE. Wound repair and regenerative medicine. J Funct Biomater. 2018;9:2.
108.Hu B, Owh C, Chee PL, Leow WR, Liu X, Wu YL, et al. Supramolecular hydrogels for antimicrobial therapy. Chem Soc Rev. 2018;47:6917–29.
109.Pang Q, Lou D, Li S, Wang G, Qiao B, Dong S, et al. Smart flexible electronics-integrated wound dressing for real-time monitoring and on-demand treatment of infected wounds. Adv Sci (Weinh). 2020;7:1902673.
110.Gao G, Jiang YW, Jia HR, Wu FG. Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection. Biomaterials. 2019;188:83–95.
111.Yang Z, Huang R, Zheng B, Guo W, Li C, He W, et al. Highly stretchable, adhesive, biocompatible, and antibacterial hydrogel dressings for wound healing. Adv Sci (Weinh). 2021;8:2003627.
112.Wang K, Wang J, Li L, Xu L, Feng N, Wang Y, et al. Synthesis of a novel anti-freezing, non-drying antibacterial hydrogel dressing by one-pot method. Chem Eng J. 2019;372:216–25.
113.Raghunath A, Perumal E. Metal oxide nanoparticles as antimicrobial agents: a promise for the future. Int J Antimicrob Agents. 2017;49:137–52.
114.Tang S, Zheng J. Antibacterial activity of silver nanoparticles: structural effects. Adv Healthc Mater. 2018;7:e1701503.
115.Kumar P, Kizhakkedathu JN, Straus SK. Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo. Biomol Ther. 2018;8:1.
116.Stern D, Cui H. Crafting polymeric and Peptidic hydrogels for improved wound healing. Adv Healthc Mater. 2019;8:1900104.
117.Wang C, Shao C, Fang Y, Wang J, Dong N, Shan A. Binding loop of sunflower trypsin inhibitor 1 serves as a design motif for proteolysis-resistant antimicrobial peptides. Acta Biomater. 2021;124:254–69.
118.Wei S, Xu P, Yao Z, Cui X, Lei X, Li L, et al. A composite hydrogel with co-delivery of antimicrobial peptides and platelet-rich plasma to enhance healing of infected wounds in diabetes. Acta Biomater. 2021;124:205–18.
119.Xiao F, Cao B, Wang C, Guo X, Li M, Xing D, et al. Pathogen-specific polymeric antimicrobials with significant membrane disruption and enhanced photodynamic damage to inhibit highly opportunistic bacteria. ACS Nano. 2019;13:7356.
120.Atefyekta S, Pihl M, Lindsay C, Heilshorn SC, Andersson M. Antibiofilm elastin-like polypeptide coatings: functionality, stability, and selectivity. Acta Biomater. 2019;83:245–56.
121.Wang Y, Yang Y, Shi Y, Song H, Yu C. Antibiotic-free antibacterial strategies enabled by nanomaterials: progress and perspectives. Adv Mater. 2020;32:e1904106.
122.Ivanova EP, Hasan J, Webb HK, Gervinskas G, Juodkazis S, Truong VK, et al. Bactericidal activity of black silicon. Nat Commun. 2013;4:2838.
123.Chung KK, Schumacher JF, Sampson EM, Burne RA, Antonelli PJ, Brennan AB. Impact of engineered surface microtopography on biofilm formation of Staphylococcus aureus. Biointerphases. 2007;2:89–94.
124.Nastulyavichus A, Kudryashov S, Saraeva I, Smirnov N, Rudenko A, Tolordava E, et al. Nanostructured steel for antibacterial applications. Laser Phys Lett. 2020;17:016003.
125.Yuan Y, Hays M, Hardwidge P, Kim J. Surface characteristics influencing bacterial adhesion to polymeric substrates. RSC Adv. 2017;7:14254–61.
126.Lei W, Ren K, Chen T, Chen X-C, Li B, Chang H, et al. Polydopamine Nanocoating for effective Photothermal killing of bacteria and fungus upon near-infrared irradiation. Adv Mater Interfaces. 2016;3:1600767.1-6.
127.Xu JW, Yao K, Xu ZK. Nanomaterials with a photothermal effect for antibacterial activities: an overview. Nanoscale. 2019;18:8680–91.
128.Ding LG, Wang S, Yao BJ, Li F, Li YA, Zhao GY, et al. Synergistic antibacterial and anti-inflammatory effects of a drug-loaded self-standing porphyrin-COF membrane for efficient skin wound healing. Adv Healthc Mater. 2021;10:e2001821.
129.Yu Y, Mei L, Shi Y, Zhang X, Cheng K, Cao F, et al. Ag-conjugated graphene quantum dots with blue light-enhanced singlet oxygen generation for ternary-mode highly-efficient antimicrobial therapy. J Mater Chem B. 2020;8:1371–82.
130.Dinh T, Tecilazich F, Kafanas A, Doupis J, Gnardellis C, Leal E, et al. Mechanisms involved in the development and healing of diabetic foot ulceration. Diabetes. 2012;61:2937–47.
131.Chereddy KK, Lopes A, Koussoroplis S, Payen V, Moia C, Zhu H, et al. Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds. Nanomedicine. 2015;11:1975–84.
132.Weng TT, Cai CH, Han CM, Wang XG. Research advances on biomaterials for the delivery of growth factors to regulate wound repair[J]. Chin J Burns Wounds. 2022;38:691–6.
133.Hui Q, Zhang L, Yang X, Yu B, Huang Z, Pang S, et al. Higher biostability of rh-aFGF-Carbomer 940 hydrogel and its effect on wound healing in a diabetic rat model. ACS Biomater Sci Eng. 2018;5:1661–8.
134.Li R, Li Y, Wu Y, Zhao Y, Chen H, Yuan Y, et al. Heparin-Poloxamer Thermosensitive hydrogel loaded with bFGF and NGF enhances peripheral nerve regeneration in diabetic rats. Biomaterials. 2018;168:24–37.
135.Zhu J, Jiang G, Hong W, Zhang Y, Xu B, Song G, et al. Rapid gelation of oxidized hyaluronic acid and succinyl chitosan for integration with insulin-loaded micelles and epidermal growth factor on diabetic wound healing. Mater Sci Eng C Mater Biol Appl. 2020;117:111273.
136.Zhu Y, Hoshi R, Chen S, Yi J, Duan C, Galiano RD, et al. Sustained release of stromal cell derived factor-1 from an antioxidant thermoresponsive hydrogel enhances dermal wound healing in diabetes. J Control Release. 2016;238:114–22.
137.Cifuentes A, Gómez-Gil V, Ortega M, Barco A, Coca S, San Roman J, et al. Chitosan hydrogels functionalized with either unfractionated heparin or bemiparin improve diabetic wound healing. Biomed Pharmacother. 2020;129:110498.
138.Lin S, Zhang Q, Li S, Zhang T, Wang L, Qin X, et al. Antioxidative and angiogenesis-promoting effects of tetrahedral framework nucleic acids in diabetic wound healing with activation of the Akt/Nrf2/HO-1 pathway. ACS Appl Mater Interfaces. 2020;12:11397–408.
139.Shen YI, Cho H, Papa AE, Burke JA, Chan XY, Duh EJ, et al. Engineered human vascularized constructs accelerate diabetic wound healing. Biomaterials. 2016;102:107–19.
140.Bai Q, Han K, Dong K, Zheng C, Zhang Y, Long Q, et al. Potential applications of nanomaterials and Technology for Diabetic Wound Healing. Int J Nanomedicine. 2020;15:9717–43.
141.Wang C, Wang M, Xu T, Zhang X, Lin C, Gao W, et al. Engineering bioactive self-healing antibacterial exosomes hydrogel for promoting chronic diabetic wound healing and complete skin regeneration. Theranostics. 2019;9:65–76.
142.Yang J, Chen Z, Pan D, Li H, Shen J. Umbilical cord-derived mesenchymal stem cell-derived exosomes combined Pluronic F127 hydrogel promote chronic diabetic wound healing and complete skin regeneration. Int J Nanomedicine. 2020;Volume 15:5911–26.
143.He M, Potuck A, Zhang Y, Chu CC. Arginine-based polyester amide/polysaccharide hydrogels and their biological response. Acta Biomater. 2014;10:2482–94.
144.Hristina K, Langerholc T, Trapecar M. Novel metabolic roles of L-arginine in body energy metabolism and possible clinical applications. J Nutr Health Aging. 2014;18:213–8.
145.Leigh B, Desneves K, Rafferty J, Pearce L, King S, Woodward MC, et al. The effect of different doses of an arginine-containing supplement on the healing of pressure ulcers. J Wound Care. 2012;21:150–6.
146.Park JE, Abrams MJ, Efron PA, Barbul A. Excessive nitric oxide impairs wound collagen accumulation. J Surg Res. 2013;183:487–92.
147.Zhou L, Zheng H, Liu Z, Wang S, Liu Z, Chen F, et al. Conductive antibacterial Hemostatic multifunctional scaffolds based on Ti(3)C(2)T(x) MXene Nanosheets for promoting multidrug-resistant bacteria-infected wound healing. ACS Nano. 2021;15:2468–80.
148.Zou F, Wang Y, Zheng Y, Xie Y, Zhang H, Chen J, et al. A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing. Bioact Mater. 2022;17:471–87.
149.Zhou W, Duan Z, Zhao J, Fu R, Zhu C, Fan D. Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing. Bioact Mater. 2022;17:1–17.
150.Shi H, Wang M, Sun Y, Yang D, Xu W, Qian H. Exosomes: emerging cell-free based therapeutics in dermatologic diseases. Front Cell Dev Biol. 2021;9:736022.
151.Sun Y, Shi H, Yin S, Ji C, Zhang X, Zhang B, et al. Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction. ACS Nano. 2018;12:7613–28.
152.Wu P, Zhang B, Shi H, Qian H, Xu W. MSC-exosome: a novel cell-free therapy for cutaneous regeneration. Cytotherapy. 2018;20:291–301.
153.Liu X, Yang Y, Li Y, Niu X, Zhao B, Wang Y, et al. Integration of stem cell-derived exosomes with in situ hydrogel glue as a promising tissue patch for articular cartilage regeneration. Nanoscale. 2017;9:4430–8.
154.Kwak G, Cheng J, Kim H, Song S, Lee SJ, Yang Y, et al. Sustained exosome-guided macrophage polarization using hydrolytically degradable PEG hydrogels for cutaneous wound healing: identification of key proteins and MiRNAs, and sustained release formulation. Small. 2022;18:2200060.
155.Shiekh P, Singh A, Kumar A. Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing. Biomaterials. 2020;249:120020.
156.Xiong Y, Chen L, Liu P, Yu T, Lin C, Yan C, et al. All-in-one: multifunctional hydrogel accelerates oxidative diabetic wound healing through timed-release of exosome and fibroblast growth factor. Small. 2022;18:2104229.
157.Galkowska H, Wojewodzka U, Olszewski WL. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. Wound Repair Regen. 2006;14:558–65.
158.Frost J, Galdeano C, Soares P, Gadd MS, Grzes KM, Ellis L, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016;7:13312.
159.Wang Y, Cao Z, Wei Q, Ma K, Hu W, Huang Q, et al. VH298-loaded extracellular vesicles released from gelatin methacryloyl hydrogel facilitate diabetic wound healing by HIF-1α-mediated enhancement of angiogenesis. Acta Biomater. 2022;147:342–55.
160.Hu W, Shang R, Yang J, Chen C, Liu Z, Liang G, et al. Skin γδ T cells and their function in wound healing. Front Immunol. 2022;13:875076.
161.Munoz LD, Sweeney MJ, Jameson JM. Skin resident gammadelta T cell function and regulation in wound repair. Int J Mol Sci. 2020;21:9286.
162.Jia Z, Lv X, Hou Y, Wang K, Ren F, Xu D, et al. Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics. Bioact Mater. 2021;6:2676–87.
163.Kai H, Yamauchi T, Ogawa Y, Tsubota A, Magome T, Miyake T, et al. Accelerated wound healing on skin by electrical stimulation with a bioelectric plaster. Adv Healthc Mater. 2017;6:22.
164.Wang C, Jiang X, Kim HJ, Zhang S, Zhou X, Chen Y, et al. Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing. Biomaterials. 2022;285:121479.
165.Wang L, Sun L, Bian F, Wang Y, Zhao Y. Self-bonded hydrogel inverse opal particles as sprayed flexible patch for wound healing. ACS Nano. 2022;16:2640–50.
166.Lohmann N, Schirmer L, Atallah P, Wandel E, Ferrer RA, Werner C, et al. Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice. Sci Transl Med. 2017;9:386.
0
Views
0
下载量
0
CSCD
- Meta-XMLDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
