Extracellular vesicles modulate key signalling pathways in refractory wound healing

Bowen Yang; Yumeng Lin; Yibo Huang; Nanxi Zhu; Ying-Qiang Shen

doi:10.1093/burnst/tkad039

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Extracellular vesicles modulate key signalling pathways in refractory wound healing

更新时间：2024-02-04

- Extracellular vesicles modulate key signalling pathways in refractory wound healing
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
  
  1. State Key Laboratory of Oral Diseases
  2. Sichuan University
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkad039
  CLC：
- Published：2023，
  
  Published Online：16 November 2023，
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Bowen Yang, Yumeng Lin, Yibo Huang, Nanxi Zhu, Ying-Qiang Shen, Extracellular vesicles modulate key signalling pathways in refractory wound healing, Burns & Trauma, Volume 11, 2023, tkad039, https://doi.org/10.1093/burnst/tkad039
DOI：

Bowen Yang, Yumeng Lin, Yibo Huang, Nanxi Zhu, Ying-Qiang Shen, Extracellular vesicles modulate key signalling pathways in refractory wound healing, Burns & Trauma, Volume 11, 2023, tkad039, https://doi.org/10.1093/burnst/tkad039 DOI：

摘要

Abstract

Chronic wounds are wounds that cannot heal properly due to various factors

such as underlying diseases

infection or reinjury

and improper healing of skin wounds and ulcers can cause a serious economic burden. Numerous studies have shown that extracellular vesicles (EVs) derived from stem/progenitor cells promote wound healing

reduce scar formation and have significant advantages over traditional treatment methods. EVs are membranous particles that carry various bioactive molecules from their cellular origins

such as cytokines

nucleic acids

enzymes

lipids and proteins. EVs can mediate cell-to-cell communication and modulate various physiological processes

such as cell differentiation

angiogenesis

immune response and tissue remodelling. In this review

we summarize the recent advances in EV-based wound healing

focusing on the signalling pathways that are regulated by EVs and their cargos. We discuss how EVs derived from different types of stem/progenitor cells can promote wound healing and reduce scar formation by modulating the Wnt/β-catenin

phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin

vascular endothelial growth factor

transforming growth factor β and JAK–STAT pathways. Moreover

we also highlight the challenges and opportunities for engineering or modifying EVs to enhance their efficacy and specificity for wound healing.

关键词

Keywords

Extracellular vesiclesRefractory woundStem/progenitor cellsScar formationEngineered extracellular vesiclesWound healingScarSignalling pathway

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