The impact of burn injury on the central nervous system

Amira Allahham; Grant Rowe; Andrew Stevenson; Mark W Fear; Ann-Maree Vallence; Fiona M Wood

doi:10.1093/burnst/tkad037

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The impact of burn injury on the central nervous system

更新时间：2024-04-19

- The impact of burn injury on the central nervous system
- Burns & Trauma Vol. 12, Issue 1, (2024)
- 作者机构：
  
  1. Burn injury research unit, School of Biomedical Sciences, University of Western Australia
  2. Fiona Wood Foundation
  3. Centre for Molecular Medicine and Innovative Therapeutics
  4. Centre for Healthy Ageing
  5. Murdoch University
  6. Burn Service of Western Australia
  7. School of Psychology, College of Health and Education, Murdoch University
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkad037
  CLC：
- Published：2024，
  
  Published Online：1 February 2024，
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Amira Allahham, Grant Rowe, Andrew Stevenson, Mark W Fear, Ann-Maree Vallence, Fiona M Wood, The impact of burn injury on the central nervous system, Burns & Trauma, Volume 12, 2024, tkad037, https://doi.org/10.1093/burnst/tkad037
DOI：

Amira Allahham, Grant Rowe, Andrew Stevenson, Mark W Fear, Ann-Maree Vallence, Fiona M Wood, The impact of burn injury on the central nervous system, Burns & Trauma, Volume 12, 2024, tkad037, https://doi.org/10.1093/burnst/tkad037 DOI：

摘要

Abstract

Burn injuries can be devastating

with life-long impacts including an increased risk of hospitalization for a wide range of secondary morbidities. One area that remains not fully understood is the impact of burn trauma on the central nervous system (CNS). This review will outline the current findings on the physiological impact that burns have on the CNS and how this may contribute to the development of neural comorbidities including mental health conditions. This review highlights the damaging effects caused by burn injuries on the CNS

characterized by changes to metabolism

molecular damage to cells and their organelles

and disturbance to sensory

motor and cognitive functions in the CNS. This damage is likely initiated by the inflammatory response that accompanies burn injury

and it is often long-lasting. Treatments used to relieve the symptoms of damage to the CNS due to burn injury often target inflammatory pathways. However

there are non-invasive treatments for burn patients that target the functional and cognitive damage caused by the burn

including transcranial magnetic stimulation and virtual reality. Future research should focus on understanding the mechanisms that underpin the impact of a burn injury on the CNS

burn severity thresholds required to inflict damage to the CNS

and acute and long-term therapies to ameliorate deleterious CNS changes after a burn.

关键词

Keywords

BurnInjuryCentral nervous systemBrainSpinal cordInflammation

references

1.Duke JM, Bauer J, Fear MW, Rea S, Wood FM, Boyd J. Burn injury, gender and cancer risk: population-based cohort study using data from Scotland and Western Australia. BMJ Open. 2014;4(1):e003845. https://doi.org/10.1136/bmjopen-2013-003845.

2.Duke JM, Randall SM, Wood FM, Boyd JH, Fear MW. Burns and long-term infectious disease morbidity: A population-based study. Burns. 2017;43(2):273‑81. https://doi.org/10.1016/j.burns.2016.10.020.

3.Fear VS, Boyd JH, Rea S, Wood FM, Duke JM, Fear MW. Burn Injury Leads to Increased Long-Term Susceptibility to Respiratory Infection in both Mouse Models and Population Studies. PLOS ONE. 2017;12(1):e0169302. https://doi.org/10.1371/journal.pone.0169302.

4.Barrett LW, Fear VS, Waithman JC, Wood FM, Fear MW. Understanding acute burn injury as a chronic disease. Burns & Trauma. 2019;7. https://doi.org/10.1186/s41038-019-0163-2.

5.Kelter BM, Holavanahalli R, Suman OE, Ryan CM, Schneider JC. Recognizing the long-term sequelae of burns as a chronic medical condition. Burns. 2020;46(2):493‑96. https://doi.org/10.1016/j.burns.2019.10.017.

6.Strudwick XL, Cowin AJ. The role of the inflammatory response in burn injury. Hot topics in burn injuries. Adelaide, South Australia, Australia: Intechopen. 2018 May 23, 37–57.

7.Flierl MA, Stahel PF, Touban BM, Beauchamp KM, Morgan SJ, Smith WR, et al. Bench-to-bedside review: burn-induced cerebral inflammation--a neglected entity? Crit Care. 2009;13:215. https://doi.org/10.1186/cc7794.

8.Jeschke MG, Gauglitz GG, Kulp GA, Finnerty CC, Williams FN, Kraft R, et al. Long-term Persistance of the pathophysiologic response to severe burn injury. PLoS One. 2011;6:e21245.

9.Jeschke MG, van Baar ME, Choudhry MA, Chung KK, Gibran NS, Logsetty S. Burn injury. Nature Reviews Disease Primers. 2020;6:1–25.

10.Andreasen NJC. Neuropsychiatric complications in burn patients. The International Journal of Psychiatry in Medicine. 1974;5:161–71. https://doi.org/10.2190/FATV-K0DW-12M7-J9BH.

11.Emery JL, Campbell Reid DA. Cerebral oedema and spastic hemiplegia following minor burns in young children. Br J Surg. 1962;50:53–6. https://doi.org/10.1002/bjs.18005021914.

12.Warlow CP, Hinton P. Early neurological disturbances following relatively minor burns in children. Lancet. 1969;2:978–82. https://doi.org/10.1016/s0140-6736(69)90538-8.

13.Baek JS. An ultrastructural study on the changes in the anterior lobe of the pituitary gland induced by severe thermal burns. Nihon Ika Daigaku Zasshi. 1987;54:441–52. https://doi.org/10.1272/jnms1923.54.441.

14.Wang Q, Ishikawa T, Michiue T, Zhu BL, Guan DW, Maeda H. Molecular pathology of brain edema after severe burns in forensic autopsy cases with special regard to the importance of reference gene selection. Int J Legal Med. 2013;127:881–9. https://doi.org/10.1007/s00414-013-0868-x.

15.Barone CM, Jimenez DF, Huxley VH, Yang XF. In vivo visualization of cerebral microcirculation in systemic thermal injury. The Journal of burn care & rehabilitation. 2000;21:20–5.

16.Sharma C, Dobson GP, Davenport LM, Morris JL, Letson HL. The role of matrix metalloproteinase-9 and its inhibitor TIMP-1 in burn injury: a systematic review. Int J Burns Trauma. 2021;11:275–88.

17.Berger J, Sprague SM, Wu Y, Davis WW, Jimenez DF, Barone CM, et al. Peripheral thermal injury causes early blood-brain barrier dysfunction and matrix metalloproteinase expression in rat. Neurol Res. 2007;29:610–4. https://doi.org/10.1179/016164107X172158.

18.Patel TH, Sprague S, Lai Q, Jimenez DF, Barone CM, Ding Y. Blood brain barrier (BBB) dysfunction associated with increased expression of tissue and urokinase plasminogen activators following peripheral thermal injury. Neurosci Lett. 2008;444:222–6. https://doi.org/10.1016/j.neulet.2008.08.020.

19.Reyes R, Guo M, Swann K, Shetgeri SU, Sprague SM, Jimenez DF, et al. Role of tumor necrosis factor-alpha and matrix metalloproteinase-9 in blood-brain barrier disruption after peripheral thermal injury in rats. J Neurosurg. 2009;110:1218–26. https://doi.org/10.3171/2008.8.JNS08382.

20.Swann K, Berger J, Sprague SM, Wu Y, Lai Q, Jimenez DF, et al. Peripheral thermal injury causes blood-brain barrier dysfunction and matrix metalloproteinase (MMP) expression in rat. Brain Res. 2007;1129:26–33. https://doi.org/10.1016/j.brainres.2006.10.061.

21.Hu J, Zhang Y, Ding S, Li H. Dynamic observation on opening of the blood-brain barrier in the primary stage of severely scalded rabbits, a multimodal study. J Burn Care Res. 2016;37:e279–86. https://doi.org/10.1097/BCR.0000000000000172.

22.Li HT, Ying DJ, He XC, Sun JS, Chen L. Stereoscopic study on capillary density of early brain oedema in a dog postburn model. Injury. 2009;40:835–9. https://doi.org/10.1016/j.injury.2008.10.009.

23.Yang J, Ma K, Zhang C, Liu Y, Liang F, Hu W, et al. Burns impair blood-brain barrier and mesenchymal stem cells can reverse the process in mice. Front Immunol. 2020;11:578879. https://doi.org/10.3389/fimmu.2020.578879.

24.Reyes R, Jr, Wu Y, Lai Q, Mrizek M, Berger J, Jimenez DF, et al. Early inflammatory response in rat brain after peripheral thermal injury. Neurosci Lett. 2006;407:11–5. https://doi.org/10.1016/j.neulet.2006.07.071.

25.Demiralay E, Saglam IY, Ozdamar EN, Sehirli AO, Sener G, Saglam E. nNOS expression in the brain of rats after burn and the effect of the ACE inhibitor captopril. Burns. 2013;39:897–904. https://doi.org/10.1016/j.burns.2012.10.008.

26.Lestaevel P, Agay D, Peinnequin A, Cruz C, Cespuglio R, Clarençon D, et al. Effects of a thermal injury on brain and blood nitric oxide (NO) content in the rat. Burns. 2003;29:557–62. https://doi.org/10.1016/s0305-4179(03)00152-9.

27.Ozaki-Okayama Y, Matsumura K, Ibuki T, Ueda M, Yamazaki Y, Tanaka Y, et al. Burn injury enhances brain prostaglandin E2 production through induction of cyclooxygenase-2 and microsomal prostaglandin E synthase in cerebral vascular endothelial cells in rats. Crit Care Med. 2004;32:795–800. https://doi.org/10.1097/01.ccm.0000114576.60077.fc.

28.Andreasson K. Emerging roles of PGE2 receptors in models of neurological disease. Prostaglandins & Other Lipid Mediators. 2010;91:104–12. https://doi.org/10.1016/j.prostaglandins.2009.04.003.

29.Wang Q, Ishikawa T, Michiue T, Zhu BL, Maeda H. Evaluation of human brain damage in fire fatality by quantification of basic fibroblast growth factor (bFGF), glial fibrillary acidic protein (GFAP) and single-stranded DNA (ssDNA) immunoreactivities. Forensic Sci Int. 2011;211:19–26. https://doi.org/10.1016/j.forsciint.2011.03.037.

30.Quan L, Zhu BL, Oritani S, Ishida K, Fujita MQ, Maeda H. Intranuclear ubiquitin immunoreactivity in the pigmented neurons of the substantia nigra in fire fatalities. Int J Legal Med. 2001;114:310–5. https://doi.org/10.1007/s004140000192.

31.Zhang QH, Li JC, Dong N, TANG LU-MING, ZHU XIAO-MEI, SHENG ZHI-YONG, et al. Burn injury induces gelsolin expression and cleavage in the brain of mice. Neuroscience. 2013;228:60–72. https://doi.org/10.1016/j.neuroscience.2012.10.013.

32.Li H, Ying D, Sun J, Bian X, Zhang Y, He B. Comparative observation with MRI and pathology of brain edema at the early stage of severe burn. Chinese Journal of Traumatology= Zhonghua Chuang Shang Za Zhi. 2001;4:226–30.

33.Patwa S, Benson CA, Dyer L, Olson KL, Bangalore L, Hill M, et al. Spinal cord motor neuron plasticity accompanies second-degree burn injury and chronic pain. Physiol Rep. 2019;7:e14288. https://doi.org/10.14814/phy2.14288.

34.Varga A, Mészár Z, Sivadó M, Bácskai T, Végh B, Kókai É, et al. Spinal excitatory dynorphinergic interneurons contribute to burn injury-induced nociception mediated by phosphorylated histone 3 at serine 10 in rodents. Int J Mol Sci. 2021;22(5). https://doi.org/10.3390/ijms22052297.

35.Sorkin L, Svensson CI, Jones-Cordero TL, Hefferan MP, Campana WM. Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat. J Neurosci Res. 2009;87:948–55. https://doi.org/10.1002/jnr.21905.

36.Svoboda J, Motin V, Hájek I, Syková E. Increase in extracellular potassium level in rat spinal dorsal horn induced by noxious stimulation and peripheral injury. Brain Res. 1988;458:97–105. https://doi.org/10.1016/0006-78993(88)90500-8.

37.White JP, Ko CW, Fidalgo AR, Cibelli M, Paule CC, Anderson PJ, et al. Severe burn injury induces a characteristic activation of extracellular signal-regulated kinase 1/2 in spinal dorsal horn neurons. Eur J Pain. 2011;15:683–90. https://doi.org/10.1016/j.ejpain.2010.12.006.

38.de Ceballos ML, Jenner P, Marsden CD. Increased [met]enkephalin and decreased substance P in spinal cord following thermal injury to one limb. Neuroscience. 1990;36:731–6. https://doi.org/10.1016/0306-4522(90)90015-v.

39.Zhang R, Xu B, Zhang N, Niu J, Zhang M, Zhang Q, et al. Spinal microglia-derived TNF promotes the astrocytic JNK/CXCL1 pathway activation in a mouse model of burn pain. Brain Behav Immun. 2022;102:23–39. https://doi.org/10.1016/j.bbi.2022.02.006.

40.Moiseev EA, Shurygin D, Beliaev VE. State of the hypothalamo-hypophyseal system in experimental burns. Biull Eksp Biol Med. 1971;71:113–5.

41.Stoner HB, Elson PM. The effect of injury on monoamine concentrations in the rat hypothalamus. J Neurochem. 1971;18:1837–46. https://doi.org/10.1111/j.1471-4159.1971.tb09589.x.

42.Palmieri TL, Levine S, Schonfeld-Warden N, OʼMara MS, Greenhalgh DG. Hypothalamic-pituitary-adrenal axis response to sustained stress after major burn injury in children. J Burn Care Res. 2006;27:742–8. https://doi.org/10.1097/01.BCR.0000238098.43888.07.

43.Fuchs PC, Groger A, Bozkurt A, Johnen D, Wolter T, Pallua N. Cortisol in severely burned patients: investigations on disturbance of the hypothalamic-pituitary-adrenal axis. Shock. 2007;28:662–7. https://doi.org/10.1097/shk.0b0318123e53b.

44.Emanuele NV, LaPaglia N, Kovacs EJ, Emanuele MA. The impact of burn injury and ethanol on the cytokine network of the mouse hypothalamus: reproductive implications. Cytokine. 2005;30:109–15. https://doi.org/10.1016/j.cyto.2004.11.004.

45.Mårtensson J, Goodwin CW, Blake R. Mitochondrial glutathione in hypermetabolic rats following burn injury and thyroid hormone administration: evidence of a selective effect on brain glutathione by burn injury. Metabolism. 1992;41:273–7. https://doi.org/10.1016/0026-0495(92)90270-k.

46.Carter EA, Paul KW, Barrow SA, Fischman AJ, Tompkins RG. Previous burn injury predisposes mice to lipopolysaccharide-induced changes in glucose metabolism. J Burn Care Res. 2012;33:683–9. https://doi.org/10.1097/BCR.0b013e31825d6a86.

47.Carter EA, Tompkins RG, Babich JW, Correia JA, Fischman AJ. Decreased cerebral glucose utilization in rats during the ebb phase of thermal injury. J Trauma Acute Care Surg. 1996;40:930–5.

48.Gamelli RL, Liu H, He LK, Hofmann CA. Alterations of glucose transporter mRNA and protein levels in brain following thermal injury and sepsis in mice. Shock. 1994;1:395–400. https://doi.org/10.1097/00024382-199406000-00001.

49.Chance WT, Nelson JL, Kim M, Foley-Nelson T, Chen MH, Fischer JE. Burn-induced alterations in feeding, energy expenditure, and brain amine neurotransmitters in rats. J Trauma. 1987;27:503–9. https://doi.org/10.1097/00005373-198705000-00008.

50.Green D, Ruparel S, Gao X, Ruparel N, Patil M, Akopian A, et al. Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury. Mol Pain. 2016;12:12. https://doi.org/10.1177/1744806916661725.

51.Zhang Q, Carter EA, Ma B, Fischman AJ, Tompkins RG. Burn-related metabolic and signaling changes in rat brain. J Burn Care Res. 2008;29:346–52. https://doi.org/10.1097/BCR.0b013e3181667387.

52.Joo SY, Cho YS, Lee KJ, Lee SY, Seo CH. Frontal lobe oxyhemoglobin levels in patients with lower extremity burns assessed using a functional near-infrared spectroscopy device during usual walking: a pilot study. Comput Methods Biomech Biomed Engin. 2021;24:115–21. https://doi.org/10.1080/10255842.2020.1812583.

53.Ma L, Zhou Y, Khan MAS, Yasuhara S, Martyn JAJ. Burn-induced microglia activation is associated with motor neuron degeneration and muscle wasting in mice. Shock. 2019;51:569–79. https://doi.org/10.1097/SHK.0000000000001300.

54.Wu SH, Huang SH, Cheng KI, Chai CY, Yeh JL, Wu TC, et al. Third-degree hindpaw burn injury induced apoptosis of lumbar spinal cord ventral horn motor neurons and sciatic nerve and muscle atrophy in rats. Biomed Res Int. 2015;2015:372819. https://doi.org/10.1155/2015/372819.

55.Holavanahalli RK, Helm PA, Kowalske KJ. Long-term outcomes in patients surviving large burns: the musculoskeletal system. Journal of Burn Care & Research. 2016;37:243–54. https://doi.org/10.1097/bcr.0000000000000257.

56.Coderre TJ, Melzack R. Increased pain sensitivity following heat injury involves a central mechanism. Behav Brain Res. 1985;15:259–62. https://doi.org/10.1016/0166-4328(85)90181-0.

57.Marquez S, Turley JJ, Peters WJ. Neuropathy in burn patients. Brain. 1993;116:471–83. https://doi.org/10.1093/brain/116.2.471.

58.Guo Y, Benson C, Hill M, Henry S, Effraim P, Waxman SG, et al. Therapeutic potential of Pak1 inhibition for pain associated with cutaneous burn injury. Mol Pain. 2018;14:1744806918788648. https://doi.org/10.1177/1744806918788648.

59.Tan AM, Samad OA, Liu S, Bandaru S, Zhao P, Waxman SG. Burn injury-induced mechanical allodynia is maintained by Rac1-regulated dendritic spine dysgenesis. Exp Neurol. 2013;248:509–19. https://doi.org/10.1016/j.expneurol.2013.07.017.

60.Sorkin LS, Doom CM, Maruyama KP, Nanigian DB. Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase. Eur J Pharmacol. 2008;587:118–23. https://doi.org/10.1016/j.ejphar.2008.03.033.

61.Wang S, Zhang L, Ma Y, Chen L, Tian Y, Mao J, et al. Nociceptive behavior following hindpaw burn injury in young rats: response to systemic morphine. Pain Med. 2011;12:87–98. https://doi.org/10.1111/j.1526-4637.2010.01021.x.

62.Miao J, Zhou X, Ding W, You Z, Doheny J, Mei W, et al. PGC-1α haploinsufficiency promotes pain chronification after burn injury. Anesth Analg. 2020;130:240–7.

63.Nozaki-Taguchi N, Yaksh TL. Pharmacology of spinal glutamatergic receptors in post-thermal injury-evoked tactile allodynia and thermal hyperalgesia. Anesthesiology. 2002;96:617–26. https://doi.org/10.1097/00000542-200203000-00018.

64.Sosanya NM, Garza TH, Stacey W, Crimmins SL, Christy RJ, Cheppudira BP. Involvement of brain-derived neurotrophic factor (BDNF) in chronic intermittent stress-induced enhanced mechanical allodynia in a rat model of burn pain. BMC Neurosci. 2019;20:17. https://doi.org/10.1186/s12868-019-0500-1.

65.Sosanya NM, Trevino AV, Chavez RL, Christy R, Cheppudira B. Sound-stress-induced altered nociceptive behaviors are associated with increased spinal CRFR2 gene expression in a rat model of burn injury. J Pain Res. 2017;10:2135–45. https://doi.org/10.2147/JPR.S144055.

66.Nozaki-Taguchi N, Yaksh TL. Spinal and peripheral mu opioids and the development of secondary tactile allodynia after thermal injury. Anesth Analg. 2002;94:968–74table of contents. https://doi.org/10.1097/00000539-200204000-00036.

67.Deveci M, Bozkurt M, Sengezer M. Clonus: an unusual delayed neurological complication in electrical burn injury. Burns. 2001;27:647–51. https://doi.org/10.1016/s0305-4179(00)00160-1.

68.Palao R, Monge I, Ruiz M, Barret JP. Chemical burns: pathophysiology and treatment. Burns. 2010;36:295–304.

69.Xiang Y, Zhou W, Wang P, Yang H, Gao F, Xiang H, et al. Alkali burn induced corneal spontaneous pain and activated neuropathic pain matrix in the central nervous system in mice. Cornea. 2017;36:1408–14. https://doi.org/10.1097/ICO.0000000000001336.

70.Halm MP, Poquin D, Lestaevel P, Chancerelle Y, Graff C. Brain and cognitive impairments from burn injury in rats. Burns. 2006;32:570–6. https://doi.org/10.1016/j.burns.2005.12.005.

71.Zhang QH, Hao JW, Li GL, Ji XJ, Zhou M, Yao YM. Long-lasting neurobehavioral alterations in burn-injured mice resembling post-traumatic stress disorder in humans. Exp Neurol. 2020;323:113084.

72.Gupta D, Kaushik D, Mohan V. Role of neurotransmitters in the regulation of cutaneous wound healing. Exp Brain Res. 2022;240:1649–59. https://doi.org/10.1007/s00221-022-06372-0.

73.Chance WT, Berlatzky Y, Minnema K, Trocki O, Alexander JW, Fischer JE. Burn trauma induces anorexia and aberrations in CNS amine neurotransmitters. J Trauma. 1985;25:501–7. https://doi.org/10.1097/00005373-198506000-00005.

74.Wang Z, Chen L, Rong X, Wang X. Upregulation of MAOA in the hippocampus results in delayed depressive-like behaviors in burn mice. Burns. 2017;S0305-4179(17):30165–1.

75.Purohit M, Goldstein R, Nadler D, Mathews K, Slocum C, Gerrard P, et al. Cognition in patients with burn injury in the inpatient rehabilitation population. Arch Phys Med Rehabil. 2014;95:1342–9. https://doi.org/10.1016/j.apmr.2014.01.029.

76.Kim JJ, Diamond DM. The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci. 2002;3:453–62. https://doi.org/10.1038/nrn849.

77.Mohseni Moallem Kolaei N, Ayatollahi H, Elyasi F. Delirium in burn patients: developing a mobile application for assessment and diagnosis. Journal of Burn Care & Research. 2020;42:87–92. https://doi.org/10.1093/jbcr/iraa122.

78.Wilson JE, Mart MF, Cunningham C, Shehabi Y, Girard TD, MacLullich A, et al. Delirium. Nature Reviews Disease Primers. 2020;6:90. https://doi.org/10.1038/s41572-020-00223-4.

79.Agarwal V, O'Neill PJ, Cotton BA, Pun BT, Haney S, Thompson J, et al. Prevalence and risk factors for development of delirium in burn intensive care unit patients. Journal of Burn Care & Research. 2010;31:706–15. https://doi.org/10.1097/BCR.0b013e3181eebee9.

80.MacLullich AMJ, Beaglehole A, Hall RJ, Meagher DJ. Delirium and long-term cognitive impairment. International Review of Psychiatry. 2009;21:30–42. https://doi.org/10.1080/09540260802675031.

81.Wu ZS, Wu SH, Lee SS, Lin CH, Chang CH, Lo JJ, et al. Dose-dependent effect of hyperbaric oxygen treatment on burn-induced neuropathic pain in rats. Int J Mol Sci. 2019;20(8):1951.

82.Wu ZS, Lo JJ, Wu SH, Wang CZ, Chen RF, Lee SS, et al. Early hyperbaric oxygen treatment attenuates burn-induced neuroinflammation by inhibiting the galectin-3-dependent toll-like receptor-4 pathway in a rat model. Int J Mol Sci. 2018;19(8):2195.

83.Kang DW, Choi JG, Kim J, Park JB, Lee JH, Kim HW. Bee venom reduces burn-induced pain via the suppression of peripheral and central substance P expression in mice. J Vet Sci. 2021;22:e9. https://doi.org/10.4142/jvs.2021.22.e9.

84.Lin CH, Wu SH, Lee SS, Lin YN, Kuo YR, Chai CY, et al. Autologous adipose-derived stem cells reduce burn-induced neuropathic pain in a rat model. Int J Mol Sci. 2017;19(1):34.

85.Wu SH, Huang SH, Lo YC, Chai CY, Lee SS, Chang KP, et al. Autologous adipose-derived stem cells attenuate muscular atrophy and protect spinal cord ventral horn motor neurons in an animal model of burn injury. Cytotherapy. 2015;17:1066–75. https://doi.org/10.1016/j.jcyt.2015.03.687.

86.Yin Q, Wang JF, Xu XH, Xie H. Effect of lycopene on pain facilitation and the SIRT1/mTOR pathway in the dorsal horn of burn injury rats. Eur J Pharmacol. 2020;889:173365.

87.Khan A, Shal B, Naveed M, Nasir B, Irshad N, Ali H, et al. Matrine alleviates neurobehavioral alterations via modulation of JNK-mediated caspase-3 and BDNF/VEGF signaling in a mouse model of burn injury. Psychopharmacology. 2020;237:2327–43. https://doi.org/10.1007/s00213-020-05537-5.

88.Zhang T, Zhang R, Xu B, Zhang M, Zhang Q, Li N, et al. Spinal endomorphins attenuate burn-injury pain in male mice by inhibiting p38 MAPK signaling pathway through the mu-opioid receptor. Eur J Pharmacol. 2021;903:174139. https://doi.org/10.1016/j.ejphar.2021.174139.

89.Zhou Y, Leung-Pitt Y, Deng H, Ren Y, You Z, Kem WR, et al. Nonopioid GTS-21 mitigates burn injury pain in rats by decreasing spinal cord inflammatory responses. Anesth Analg. 2021;132:240–52. https://doi.org/10.1213/ANE.0000000000005274.

90.Ji Q, Jia H, Dai H, Li W, Zhang L. Protective effects of pentoxifylline on the brain following remote burn injury. Burns. 2010;36:1300–8. https://doi.org/10.1016/j.burns.2010.05.010.

91.Zhang Q-H, Chen Q, Kang J-R, Liu C, Dong N, Zhu X-M, et al. Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury. J Neuroinflammation. 2011;8:1–18.

92.Gatson JW, Maass DL, Simpkins JW, Idris AH, Minei JP, Wigginton JG. Estrogen treatment following severe burn injury reduces brain inflammation and apoptotic signaling. J Neuroinflammation. 2009;6:30. https://doi.org/10.1186/1742-2094-6-30.

93.Wu SH, Lu IC, Lee SS, Kwan AL, Chai CY, Huang SH. Erythropoietin attenuates motor neuron programmed cell death in a burn animal model. PloS one. 2018;13(1):e0190039.

94.Torres-Pérez JV, Adamek P, Palecek J, Vizcaychipi M, Nagy I, Varga A. The NA(v)1.7 blocker protoxin II reduces burn injury-induced spinal nociceptive processing. J Mol Med (Berl). 2018;96:75–84. https://doi.org/10.1007/s00109-017-1599-0.

95.Saglam IY, Ozdamar EN, Demiralay E, Sehirli AO, Sener G, Saglam E. The effect of captopril on brain apoptosis after burn injury in rats. Turk Neurosurg. 2013;23:366–71. https://doi.org/10.5137/1019-5149.JTN.7100-12.2.

96.Thibaut A, Ohrtman EA, Morales-Quezada L, Simko LC, Ryan CM, Zafonte R, et al. Distinct behavioral response of primary motor cortex stimulation in itch and pain after burn injury. Neurosci Lett. 2019;690:89–94. https://doi.org/10.1016/j.neulet.2018.10.013.

97.Bermo MS, Zacharias C, Patterson D, Wilson A, Sharar S, Minoshima S, et al. The role of the cerebellum in pain perception: a brain SPECT perfusion study in patients with burn injuries. J Neuroimaging. 2020;30:815–21. https://doi.org/10.1111/jon.12759.

98.Bermo MS, Patterson D, Sharar SR, Hoffman H, Lewis DH. Virtual reality to relieve pain in burn patients undergoing imaging and treatment. Top Magn Reson Imaging. 2020;29(4):203–8.

99.Mott J, Bucolo S, Cuttle L, Mill J, Hilder M, Miller K, et al. The efficacy of an augmented virtual reality system to alleviate pain in children undergoing burns dressing changes: a randomised controlled trial. Burns. 2008;34:803–8. https://doi.org/10.1016/j.burns.2007.10.010.

100.Leung A, Shirvalkar P, Chen R, Kuluva J, Vaninetti M, Bermudes R, et al. Transcranial magnetic stimulation for pain, headache, and comorbid depression: INS-NANS expert consensus panel review and recommendation. Neuromodulation: Technology at the Neural. Interface. 2020;23:267–90. https://doi.org/10.1111/ner.13094.

101.Pacheco-Barrios K, Cardenas-Rojas A, Thibaut A, Costa B, Ferreira I, Caumo W, et al. Methods and strategies of tDCS for the treatment of pain: current status and future directions. Expert review of medical devices. 2020;17:879–98.

102.Lefaucheur J-P, André-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH, et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol. 2014;125:2150–206. https://doi.org/10.1016/j.clinph.2014.05.021.

103.Luber B, Lisanby SH. Enhancement of human cognitive performance using transcranial magnetic stimulation (TMS). NeuroImage. 2014;85:961–70. https://doi.org/10.1016/j.neuroimage.2013.06.007.

104.Seo CH, Jang KU, Lee BC, Choi IG, Kim JH, Chun W, et al. Transcranial magnetic stimulation can diagnose electrical burn-induced myelopathy. Burns. 2011;37:687–91. https://doi.org/10.1016/j.burns.2011.01.025.

105.Whife CJ, Vallence AM, Edgar DW, Wood FM. Decreased neuroplasticity in minor burn injury survivors compared to non-injured adults: a pilot study in burn injury survivors aged 45 years and older. Burns. 2021;47:327–37. https://doi.org/10.1016/j.burns.2020.10.024.

106.Whife CJ, Vallence AM, Edgar DW, Wood FM. No difference observed in short-interval intracortical inhibition in older burn-injury survivors compared to non-injured older adults: a pilot study. Burns. 2019;45:1131–8. https://doi.org/10.1016/j.burns.2019.02.020.

107.Garside T, Wood FM, Vallence A-M. Case series investigating the cortical silent period after burns using transcranial magnetic stimulation. Burns. 2018;44:1195–202.

108.Lefaucheur J-P, Antal A, Ayache SS, Benninger DH, Brunelin J, Cogiamanian F, et al. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clin Neurophysiol. 2017;128:56–92. https://doi.org/10.1016/j.clinph.2016.10.087.

109.Ferrucci R, Cortese F, Priori A. Cerebellar tDCS: how to do it. Cerebellum. 2015;14:27–30. https://doi.org/10.1007/s12311-014-0599-7.

110.Seewoo BJ, Hennessy LA, Jaeschke LA, Mackie LA, Etherington SJ, Dunlop SA, et al. A preclinical study of standard versus accelerated transcranial magnetic stimulation for depression in adolescents. Journal of Child and Adolescent Psychopharmacology. 2022;32:187–93.

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