Mitochondrial dysfunction and mitophagy: crucial players in burn trauma and wound healing
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
1. Department of Biological Sciences
2. National University of Singapore
3. State Key Laboratory of Trauma
4. Southwest Hospital, Third Military Medical University (Army Medical University)
5. Chongqing Key Laboratory for Disease Proteomics
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkad029
CLC：Published：2023，
Published Online：14 July 2023，
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Harshini Sheeja Prabhakaran, Dongxue Hu, Weifeng He, Gaoxing Luo, Yih-Cherng Liou, Mitochondrial dysfunction and mitophagy: crucial players in burn trauma and wound healing, Burns & Trauma, Volume 11, 2023, tkad029, https://doi.org/10.1093/burnst/tkad029
摘要
Abstract
Burn injuries are a significant cause of death worldwide
leading to systemic inflammation
multiple organ failure and sepsis. The progression of burn injury is explicitly correlated with mitochondrial homeostasis
which is disrupted by the hyperinflammation induced by burn injury
leading to mitochondrial dysfunction and cell death. Mitophagy plays a crucial role in maintaining cellular homeostasis by selectively removing damaged mitochondria. A growing body of evidence from various disease models suggest that pharmacological interventions targeting mitophagy could be a promising therapeutic strategy. Recent studies have shown that mitophagy plays a crucial role in wound healing and burn injury. Furthermore
chemicals targeting mitophagy have also been shown to improve wound recovery
highlighting the potential for novel therapeutic strategies based on an in-depth exploration of the molecular mechanisms regulating mitophagy and its association with skin wound healing.
关键词
Keywords
MitophagyMitochondriaWound healingBurn traumaMacroautophagy
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