Targeting neuronal mitophagy in ischemic stroke: an update
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
1. Department of Clinical Pharmacy
2. Zhejiang University School of Medicine
3. Institute of Pharmacology & Toxicology
4. Zhejiang University
5. Jinhua Institute of Zhejiang University
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkad018
CLC：Published：2023，
Published Online：31 May 2023，
扫 描 看 全 文
Jun Li, Jiaying Wu, Xinyu Zhou, Yangyang Lu, Yuyang Ge, Xiangnan Zhang, Targeting neuronal mitophagy in ischemic stroke: an update, Burns & Trauma, Volume 11, 2023, tkad018, https://doi.org/10.1093/burnst/tkad018
摘要
Abstract
Cerebral ischemia is a neurological disorder associated with complex pathological mechanisms
including autophagic degradation of neuronal mitochondria
or termed mitophagy
following ischemic events. Despite being well-documented
the cellular and molecular mechanisms underlying the regulation of neuronal mitophagy remain unknown. So far
the evidence suggests neuronal autophagy and mitophagy are separately regulated in ischemic neurons
the latter being more likely activated by reperfusional injury. Specifically
given the polarized morphology of neurons
mitophagy is regulated by different neuronal compartments
with axonal mitochondria being degraded by autophagy in the cell body following ischemia–reperfusion insult. A variety of molecules have been associated with neuronal adaptation to ischemia
including PTEN-induced kinase 1
Parkin
BCL2 and adenovirus E1B 19-kDa-interacting protein 3 (Bnip3)
Bnip3-like (Bnip3l) and FUN14 domain-containing 1. Moreover
it is still controversial whether mitophagy protects against or instead aggravates ischemic brain injury. Here
we review recent studies on this topic and provide an updated overview of the role and regulation of mitophagy during ischemic events.
关键词
Keywords
MitophagyCerebral ischemiaNeuroprotectionPTEN-induced kinase 1ParkinBCL2 and adenovirus E1B 19-kDa-interacting protein 3Bnip3-likeFUN14 domain-containing 1
references
1.Hossmann KA. Pathophysiological basis of translational stroke research. Folia Neuropathol. 2009;47:213–27.
2.Eltzschig HK, Eckle T. Ischemia and reperfusion--from mechanism to translation. Nat Med. 2011;17:1391–401.
3.George PM, Steinberg GK. Novel stroke therapeutics: Unraveling stroke pathophysiology and its impact on clinical treatments. Neuron. 2015;87:297–309.
4.Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol. 2010;87:779–89.
5.Liu J, Wang Y, Akamatsu Y, Lee CC, Stetler RA, Lawton MT, et al. Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials. Prog Neurobiol. 2014;115:138–56.
6.Chouchani ET, Pell VR, Gaude E, Aksentijevic D, Sundier SY, Robb EL, et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 2014;515:431–5.
7.Rangaraju V, Lewis TL, Jr, Hirabayashi Y, Bergami M, Motori E, Cartoni R, et al. Pleiotropic mitochondria: the influence of mitochondria on neuronal development and disease. J Neurosci. 2019;39:8200–8.
8.Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469:221–5.
9.Kesharwani R, Sarmah D, Kaur H, Mounika L, Verma G, Pabbala V, et al. Interplay between Mitophagy and Inflammasomes in neurological disorders. ACS Chem Neurosci. 2019;10:2195–208.
10.Zhang X, Yan H, Yuan Y, Gao J, Shen Z, Cheng Y, et al. Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy. 2013;9:1321–33.
11.Zuo W, Zhang S, Xia CY, Guo XF, He WB, Chen NH. Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: the role of inhibition of Drp1 in ischemic brain damage. Neuropharmacology. 2014;86:103–15.
12.Shi RY, Zhu SH, Li V, Gibson SB, Xu XS, Kong JM. BNIP3 interacting with LC3 triggers excessive mitophagy in delayed neuronal death in stroke. CNS Neurosci Ther. 2014;20:1045–55.
13.Demyanenko SV, Panchenko SN, Uzdensky AB. Expression of neuronal and signaling proteins in penumbra around a photothrombotic infarction core in rat cerebral cortex. Biochemistry (Mosc). 2015;80:790–9.
14.Wen H, Li L, Zhan L, Zuo Y, Li K, Qiu M, et al. Hypoxic postconditioning promotes mitophagy against transient global cerebral ischemia via PINK1/parkin-induced mitochondrial ubiquitination in adult rats. Cell Death Dis. 2021;12:630.
15.He Q, Li Z, Meng C, Wu J, Zhao Y, Zhao J. Parkin-dependent Mitophagy is required for the inhibition of ATF4 on NLRP3 Inflammasome activation in cerebral ischemia-reperfusion injury in rats. Cell. 2019;8:897–913.
16.Feng J, Chen X, Lu S, Li W, Yang D, Su W, et al. Naringin attenuates cerebral ischemia-reperfusion injury through inhibiting Peroxynitrite-mediated Mitophagy activation. Mol Neurobiol. 2018;55:9029–42.
17.Benavides GA, Liang Q, Dodson M, Darley-Usmar V, Zhang J. Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons. Free Radic Biol Med. 2013;65:1215–28.
18.Zuo W, Yan F, Liu Z, Zhang B. miR-330 regulates Drp-1 mediated mitophagy by targeting PGAM5 in a rat model of permanent focal cerebral ischemia. Eur J Pharmacol. 2020;880:173143.
19.Di Y, He YL, Zhao T, Huang X, Wu KW, Liu SH, et al. Methylene blue reduces acute cerebral ischemic injury via the induction of Mitophagy. Molecular medicine (Cambridge, Mass). 2015;21:420–9.
20.Li S, Sun X, Xu L, Sun R, Ma Z, Deng X, et al. Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK. Eur J Pharmacol. 2017;815:118–26.
21.Li F, Tan J, Zhou F, Hu Z, Yang B. Heat shock protein B8 (HSPB8) reduces oxygen-glucose deprivation/reperfusion injury via the induction of Mitophagy. Cell Physiol Biochem. 2018;48:1492–504.
22.Zhang Z, Yu J. NR4A1 promotes cerebral ischemia reperfusion injury by repressing Mfn2-mediated Mitophagy and inactivating the MAPK-ERK-CREB Signaling pathway. Neurochem Res. 2018;43:1963–77.
23.Shen Z, Zheng Y, Wu J, Chen Y, Wu X, Zhou Y, et al. PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window. Autophagy. 2017;13:473–85.
24.Yuan Y, Zheng Y, Zhang X, Chen Y, Wu X, Wu J, et al. BNIP3L/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2. Autophagy. 2017;13:1754–66.
25.Cai Y, Yang E, Yao X, Zhang X, Wang Q, Wang Y, et al. FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury. Redox Biol. 2021;38:101792.
26.Li Q, Zhang T, Wang J, Zhang Z, Zhai Y, Yang GY, et al. Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke. Biochem Biophys Res Commun. 2014;444:182–8.
27.Pineda-Ramírez N, Alquisiras-Burgos I, Ortiz-Plata A, Ruiz-Tachiquín ME, Espinoza-Rojo M, Aguilera P. Resveratrol activates neuronal autophagy through AMPK in the ischemic brain. Mol Neurobiol. 2020;57:1055–69.
28.Su SH, Wu YF, Lin Q, Wang DP, Hai J. URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion. J Neuroinflammation. 2019;16:260.
29.Wu M, Lu G, Lao YZ, Zhang H, Zheng D, Zheng ZQ, et al. Garciesculenxanthone B induces PINK1-parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice. Acta Pharmacol Sin. 2021;42:199–208.
30.Guo Q, Zhang YC, Wang W, Wang YQ, Liu Y, Yang Z, et al. Deoxyhypusine hydroxylase as a novel pharmacological target for ischemic stroke via inducing a unique post-translational hypusination modification. Pharmacol Res. 2022;176:106046.
31.Wang P, Shao BZ, Deng Z, Chen S, Yue Z, Miao CY. Autophagy in ischemic stroke. Prog Neurobiol. 2018;163–164:98–117.
32.Zhang Y, Cao Y, Liu C. Autophagy and ischemic stroke. Adv Exp Med Biol. 2020;1207:111–34.
33.Tuo QZ, Zhang ST, Lei P. Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications. Med Res Rev. 2022;42:259–305.
34.Shi Q, Cheng Q, Chen C. The role of autophagy in the pathogenesis of ischemic stroke. Curr Neuropharmacol. 2021;19:629–40.
35.Zheng Y, Zhang X, Wu X, Jiang L, Ahsan A, Ma S, et al. Somatic autophagy of axonal mitochondria in ischemic neurons. J Cell Biol. 2019;218:1891–907.
36.Cai Q, Zakaria HM, Simone A, Sheng ZH. Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons. Curr Biol. 2012;22:545–52.
37.Maday S, Wallace KE, Holzbaur EL. Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. J Cell Biol. 2012;196:407–17.
38.Zheng Y, Wu X, Chen Z, Zhang X. Come and eat: mitochondrial transport guides mitophagy in ischemic neuronal axons. Autophagy. 2019;15:1483–4.
39.Barber PA, Davis SM, Infeld B, Baird AE, Donnan GA, Jolley D, et al. Spontaneous reperfusion after ischemic stroke is associated with improved outcome. Stroke. 1998;29:2522–8.
40.Wu X, Zheng Y, Liu M, Li Y, Ma S, Tang W, et al. BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains. Autophagy. 2021;17:1934–46.
41.Hong T, Zhou Y, Peng L, Wu X, Li Y, Li Y, et al. Knocking down Peroxiredoxin 6 aggravates cerebral ischemia-reperfusion injury by enhancing Mitophagy. Neuroscience. 2022;482:30–42.
42.Hwang JA, Shin N, Shin HJ, Yin Y, Kwon HH, Park H, et al. Protective effects of ShcA protein silencing for Photothrombotic cerebral infarction. Transl Stroke Res. 2021;12:866–78.
43.Feng J, Chen X, Guan B, Li C, Qiu J, Shen J. Inhibition of Peroxynitrite-induced Mitophagy activation attenuates cerebral ischemia-reperfusion injury. Mol Neurobiol. 2018;55:6369–86.
44.Wang Y, Nartiss Y, Steipe B, McQuibban GA, Kim PK. ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy. 2012;8:1462–76.
45.Xiao B, Deng X, Lim GGY, Xie S, Zhou ZD, Lim KL, et al. Superoxide drives progression of parkin/PINK1-dependent mitophagy following translocation of parkin to mitochondria. Cell Death Dis. 2017;8:e3097.
46.Chen R, Zhang YY, Lan JN, Liu HM, Li W, Wu Y, et al. Ischemic Postconditioning alleviates intestinal ischemia-reperfusion injury by enhancing autophagy and suppressing oxidative stress through the Akt/GSK-3β/Nrf2 pathway in mice. Oxidative Med Cell Longev. 2020;2020:6954764.
47.Murata H, Takamatsu H, Liu S, Kataoka K, Huh NH, Sakaguchi M. NRF2 regulates PINK1 expression under oxidative stress conditions. PLoS One. 2015;10:e0142438.
48.Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, et al. Mitochondrial stasis reveals p62-mediated ubiquitination in parkin-independent Mitophagy and mitigates nonalcoholic fatty liver disease. Cell Metab. 2018;28:588–604.e585.
49.Li M, Sun M, Cao L, Gu JH, Ge J, Chen J, et al. A TIGAR-regulated metabolic pathway is critical for protection of brain ischemia. J Neurosci. 2014;34:7458–71.
50.Liu M, Zhou X, Li Y, Ma S, Pan L, Zhang X, et al. TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner. Redox Biol. 2022;53:102323.
51.Ulamek-Koziol M, Kocki J, Bogucka-Kocka A, Januszewski S, Bogucki J, Czuczwar SJ, et al. Autophagy, mitophagy and apoptotic gene changes in the hippocampal CA1 area in a rat ischemic model of Alzheimer's disease. Pharmacol Rep. 2017;69:1289–94.
52.Zuo W, Liu Z, Yan F, Mei D, Hu X, Zhang B. Hyperglycemia abolished Drp-1-mediated mitophagy at the early stage of cerebral ischemia. Eur J Pharmacol. 2019;843:34–44.
53.Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol. 2008;183:795–803.
54.Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, et al. PINK1 is selectively stabilized on impaired mitochondria to activate parkin. PLoS Biol. 2010;8:e1000298.
55.Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase parkin. Dev Cell. 2012;22:320–33.
56.Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, et al. Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature. 2014;510:162–6.
57.Uzdensky A, Demyanenko S, Fedorenko G, Lapteva T, Fedorenko A. Protein profile and morphological alterations in penumbra after focal Photothrombotic infarction in the rat cerebral cortex. Mol Neurobiol. 2017;54:4172–88.
58.Tarocco A, Morciano G, Perrone M, Cafolla C, Ferre C, Vacca T, et al. Increase of parkin and ATG5 plasmatic levels following perinatal hypoxic-ischemic encephalopathy. Sci Rep. 2022;12:7795.
59.Zhao Y, Chen F, Chen S, Liu X, Cui M, Dong Q. The Parkinson's disease-associated gene PINK1 protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1. J Neurochem. 2013;127:711–22.
60.Matic I, Cocco S, Ferraina C, Martin-Jimenez R, Florenzano F, Crosby J, et al. Neuroprotective coordination of cell mitophagy by the ATPase inhibitory factor 1. Pharmacol Res. 2016;103:56–68.
61.Li Y, Guo Q, Liu X, Wang C, Song D. PUMA-mediated mitochondrial apoptotic disruption by hypoxic postconditioning. Apoptosis. 2015;20:1026–32.
62.Ozawa K, Komatsubara AT, Nishimura Y, Sawada T, Kawafune H, Tsumoto H, et al. S-nitrosylation regulates mitochondrial quality control via activation of parkin. Sci Rep. 2013;3:2202.
63.Oh CK, Sultan A, Platzer J, Dolatabadi N, Soldner F, McClatchy DB, et al. S-Nitrosylation of PINK1 attenuates PINK1/parkin-dependent Mitophagy in hiPSC-based Parkinson's disease models. Cell Rep. 2017;21:2171–82.
64.Chen Y, Dorn GW, 2nd. PINK1-phosphorylated mitofusin 2 is a parkin receptor for culling damaged mitochondria. Science. 2013;340:471–5.
65.Chen C, Qin H, Tang J, Hu Z, Tan J, Zeng L. USP30 protects against oxygen-glucose deprivation/reperfusion induced mitochondrial fragmentation and ubiquitination and degradation of MFN2. Aging. 2021;13:6194–204.
66.Wojtyniak P, Boratynska-Jasinska A, Serwach K, Gruszczynska-Biegala J, Zablocka B, Jaworski J, et al. Mitofusin 2 integrates mitochondrial network remodelling, Mitophagy and renewal of respiratory chain proteins in neurons after oxygen and glucose deprivation. Mol Neurobiol. 2022;59:6502–18.
67.Matsushima M, Fujiwara T, Takahashi E, Minaguchi T, Eguchi Y, Tsujimoto Y, et al. Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3. Genes Chromosomes Cancer. 1998;21:230–5.
68.Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, et al. Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem. 1999;274:7–10.
69.Novak I, Kirkin V, McEwan DG, Zhang J, Wild P, Rozenknop A, et al. Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep. 2010;11:45–51.
70.Ulamek-Koziol M, Czuczwar SJ, Kocki J, Januszewski S, Bogucki J, Bogucka-Kocka A, et al. Dysregulation of autophagy, Mitophagy, and apoptosis genes in the CA3 region of the hippocampus in the ischemic model of Alzheimer's disease in the rat. Journal of Alzheimer's disease: JAD. 2019;72:1279–86.
71.Su SH, Wu YF, Wang DP, Hai J. Inhibition of excessive autophagy and mitophagy mediates neuroprotective effects of URB597 against chronic cerebral hypoperfusion. Cell Death Dis. 2018;9:733.
72.Imazu T, Shimizu S, Tagami S, Matsushima M, Nakamura Y, Miki T, et al. Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene. 1999;18:4523–9.
73.Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, et al. A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. Cell Death Differ. 1999;6:314–25.
74.Marinkovic M, Sprung M, Novak I. Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery. Autophagy. 2021;17:1232–43.
75.Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 2001;61:6669–73.
76.Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol. 2012;14:177–85.
77.Chen G, Han Z, Feng D, Chen Y, Chen L, Wu H, et al. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Mol Cell. 2014;54:362–77.
78.Li W, Zhang X, Zhuang H, Chen HG, Chen Y, Tian W, et al. MicroRNA-137 is a novel hypoxia-responsive MicroRNA that inhibits Mitophagy via regulation of two Mitophagy receptors FUNDC1 and NIX. J Biol Chem. 2014;289:10691–701.
79.Lampert MA, Orogo AM, Najor RH, Hammerling BC, Leon LJ, Wang BJ, et al. BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation. Autophagy. 2019;15:1182–98.
80.Gao F, Chen D, Si J, Hu Q, Qin Z, Fang M, et al. The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway. Hum Mol Genet. 2015;24:2528–38.
81.Zhang X, Wei M, Fan J, Yan W, Zha X, Song H, et al. Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons. Autophagy. 2021;17:1519–42.
82.Hossain MI, Marcus JM, Lee JH, Garcia PL, Singh V, Shacka JJ, et al. Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective. Autophagy. 2021;17:1330–48.
83.Liu Y, Xue X, Zhang H, Che X, Luo J, Wang P, et al. Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia. Autophagy. 2019;15:493–509.
84.Zhang M, Lu H, Xie X, Shen H, Li X, Zhang Y, et al. TMEM175 mediates lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion. Mol Brain. 2020;13:113.
85.Leiva-Rodríguez T, Romeo-Guitart D, Herrando-Grabulosa M, Muñoz-Guardiola P, Polo M, Bañuls C, et al. GRP78 overexpression triggers PINK1-IP(3)R-mediated neuroprotective Mitophagy. Biomedicine. 2021;9:1039–58.
86.Zhang Z, Yang X, Zhang S, Ma X, Kong J. BNIP3 upregulation and EndoG translocation in delayed neuronal death in stroke and in hypoxia. Stroke. 2007;38:1606–13.
87.Lee Y, Lee HY, Hanna RA, Gustafsson AB. Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of parkin in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2011;301:H1924–31.
88.Yu S, Zheng S, Leng J, Wang S, Zhao T, Liu J. Inhibition of mitochondrial calcium uniporter protects neurocytes from ischemia/reperfusion injury via the inhibition of excessive mitophagy. Neurosci Lett. 2016;628:24–9.
89.Nichols M, Elustondo PA, Warford J, Thirumaran A, Pavlov EV, Robertson GS. Global ablation of the mitochondrial calcium uniporter increases glycolysis in cortical neurons subjected to energetic stressors. J Cereb Blood Flow Metab. 2017;37:3027–41.
90.Dong H, Wang S, Zhang Z, Yu A, Liu Z. The effect of mitochondrial calcium uniporter opener spermine on diazoxide against focal cerebral ischemia--reperfusion injury in rats. Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association. 2014;23:303–9.
91.Zhang K, Yan J, Wang L, Tian X, Zhang T, Guo L, et al. The Pyk2/MCU pathway in the rat middle cerebral artery occlusion model of ischemic stroke. Neurosci Res. 2018;131:52–62.
92.Lu W, Sun J, Yoon JS, Zhang Y, Zheng L, Murphy E, et al. Mitochondrial protein PGAM5 regulates Mitophagic protection against cell necroptosis. PLoS One. 2016;11:e0147792.
93.Chen JL, Wang XX, Chen L, Tang J, Xia YF, Qian K, et al. A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy. Neuropharmacology. 2020;181:108326.
94.Shao Z, Dou S, Zhu J, Wang H, Xu D, Wang C, et al. Apelin-36 protects HT22 cells against oxygen-glucose deprivation/reperfusion-induced oxidative stress and mitochondrial dysfunction by promoting SIRT1-mediated PINK1/parkin-dependent Mitophagy. Neurotox Res. 2021;39:740–53.
95.Han B, Jiang W, Cui P, Zheng K, Dang C, Wang J, et al. Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation. Genome Med. 2021;13:47.
96.Ping F, Zhang C, Wang X, Wang Y, Zhou D, Hu J, et al. Cx32 inhibits the autophagic effect of Nur77 in SH-SY5Y cells and rat brain with ischemic stroke. Aging. 2021;13:22188–207.
97.Tian W, Zhu M, Zhou Y, Mao C, Zou R, Cui Y, et al. Electroacupuncture Pretreatment alleviates cerebral ischemia-reperfusion injury by regulating Mitophagy via mTOR-ULK1/FUNDC1 Axis in rats. Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association. 2022;31:106202.
98.Dou YN, Wu X, Fei X, Fei Z. The neuroprotective effect of increased PINK1 expression following glutamate Excitotoxicity in neuronal cells. Neuroscience. 2022;480:97–107.
99.Huang S, Hong Z, Zhang L, Guo J, Li Y, Li K. CERKL alleviates ischemia reperfusion-induced nervous system injury through modulating the SIRT1/PINK1/parkin pathway and mitophagy induction. Biol Chem. 2022;403:691–701.
100.Xue LX, Chen SF, Xue SX, Liu PD, Liu HB. LncRNA TUG1 compromised neuronal mitophagy in cerebral ischemia/reperfusion injury by targeting sirtuin 1. Cell Biol Toxicol. 2022;38:1121–36.
101.Zhang QQ, Luo L, Liu MX, Wang CJ, Wu Y, Yu KW. Enriched environment-induced neuroprotection against cerebral ischemia-reperfusion injury might be mediated via enhancing autophagy flux and Mitophagy flux. Mediat Inflamm. 2022;2022:2396487.
102.Hu Y, Sun D, Li Y, Wang X, Jiang W, Shi H, et al. Increased PINK1/parkin-mediated mitophagy explains the improved brain protective effects of slow rewarming following hypothermia after cardiac arrest in rats. Exp Neurol. 2020;330:113326.
103.Wen Y, Gu Y, Tang X, Hu Z. PINK1 overexpression protects against cerebral ischemia through parkin regulation. Environ Toxicol. 2020;35:188–93.
104.Zhang X, Yuan Y, Jiang L, Zhang J, Gao J, Shen Z, et al. Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: involvement of PARK2-dependent mitophagy. Autophagy. 2014;10:1801–13.
105.Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, et al. Essential role for nix in autophagic maturation of erythroid cells. Nature. 2008;454:232–5.
106.Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, et al. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A. 2007;104:19500–5.
107.Yamazaki T, Kirchmair A, Sato A, Buque A, Rybstein M, Petroni G, et al. Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy. Nat Immunol. 2020;21:1160–71.
108.Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, et al. Parkin and PINK1 mitigate STING-induced inflammation. Nature. 2018;561:258–62.
109.Xu Y, Tang Y, Lu J, Zhang W, Zhu Y, Zhang S, et al. PINK1-mediated mitophagy protects against hepatic ischemia/reperfusion injury by restraining NLRP3 inflammasome activation. Free Radic Biol Med. 2020;160:871–86.
0
Views
0
下载量
0
CSCD
- L-PDFDownload
- Meta-XMLDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
