Decoding the molecular landscape of keloids: new insights from single-cell transcriptomics

Yijun Xia; Youbin Wang; Mengjie Shan; Yan Hao; Zhengyun Liang

doi:10.1093/burnst/tkad017

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Decoding the molecular landscape of keloids: new insights from single-cell transcriptomics

更新时间：2023-08-29

- Decoding the molecular landscape of keloids: new insights from single-cell transcriptomics
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
  
  1. Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College
  2. Department of Plastic Surgery, Peking Union Medical College Hospital, Damucang Hutong, Xicheng District
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkad017
  CLC：
- Published：2023，
  
  Published Online：6 June 2023，
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Yijun Xia, Youbin Wang, Mengjie Shan, Yan Hao, Zhengyun Liang, Decoding the molecular landscape of keloids: new insights from single-cell transcriptomics, Burns & Trauma, Volume 11, 2023, tkad017, https://doi.org/10.1093/burnst/tkad017
DOI：

Yijun Xia, Youbin Wang, Mengjie Shan, Yan Hao, Zhengyun Liang, Decoding the molecular landscape of keloids: new insights from single-cell transcriptomics, Burns & Trauma, Volume 11, 2023, tkad017, https://doi.org/10.1093/burnst/tkad017 DOI：

摘要

Abstract

Keloids are a fibrotic disease caused by an excessive accumulation of extracellular matrix in the dermis; they have neoplasia-like properties of aggressive growth and high posttreatment recurrence rates. Therefore

it is imperative to gain additional insight into the pathobiology of keloid formation. Single-cell RNA sequencing (scRNA-seq) technology has brought data-driven innovation to understanding the pathogenesis of keloids by breaking the limitations of traditional sequencing technologies to resolve cell composition and to distinguish functional cell subtypes at an unprecedented resolution. The present review aims to cover the application of scRNA-seq technology in keloids and its exploratory findings

including the depiction of the cellular landscape of keloids

fibroblast heterogeneity

the lineage development of Schwann cells and the mesenchymal-activation phenomenon of endothelial cells. Furthermore

scRNA-seq records the transcriptional profiles of fibroblasts and immune cells in a more refined manner

and this gene expression information provides excellent material for inferring intercellular communication networks and lays an important theoretical foundation for future studies.

关键词

Keywords

KeloidscRNA-seqFibroblastSchwann cellImmune cellTranscriptomics

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