A single-stage bilayered skin reconstruction using Glyaderm® as an acellular dermal regeneration template results in improved scar quality: an intra-individual randomized controlled trial

Ignace De Decker; Henk Hoeksema; Jozef Verbelen; Petra De Coninck; Marijn Speeckaert; Sofie De Schepper; Phillip Blondeel; Ali Pirayesh; Stan Monstrey; Karel E Y Claes

doi:10.1093/burnst/tkad015

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A single-stage bilayered skin reconstruction using Glyaderm® as an acellular dermal regeneration template results in improved scar quality: an intra-individual randomized controlled trial

更新时间：2023-08-29

- A single-stage bilayered skin reconstruction using Glyaderm® as an acellular dermal regeneration template results in improved scar quality: an intra-individual randomized controlled trial
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
  
  1. Ghent University Hospital
  2. Plastic surgeon in private practice in Amsterdam
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkad015
  CLC：
- Published：2023，
  
  Published Online：2 May 2023，
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Ignace De Decker, Henk Hoeksema, Jozef Verbelen, Petra De Coninck, Marijn Speeckaert, Sofie De Schepper, Phillip Blondeel, Ali Pirayesh, Stan Monstrey, Karel E Y Claes, A single-stage bilayered skin reconstruction using Glyaderm® as an acellular dermal regeneration template results in improved scar quality: an intra-individual randomized controlled trial, Burns & Trauma, Volume 11, 2023, tkad015, https://doi.org/10.1093/burnst/tkad015
DOI：

Ignace De Decker, Henk Hoeksema, Jozef Verbelen, Petra De Coninck, Marijn Speeckaert, Sofie De Schepper, Phillip Blondeel, Ali Pirayesh, Stan Monstrey, Karel E Y Claes, A single-stage bilayered skin reconstruction using Glyaderm® as an acellular dermal regeneration template results in improved scar quality: an intra-individual randomized controlled trial, Burns & Trauma, Volume 11, 2023, tkad015, https://doi.org/10.1093/burnst/tkad015 DOI：

摘要

Abstract

BackgroundAbsence of almost the entire reticular dermal layer is inherent to the use of autologous split-thickness skin grafting (STSG) to close full-thickness wounds

often resulting in hypertrophic scars and contractures. Many dermal substitutes have been developed

but unfortunately most have varying results in terms of cosmetic and/or functional improvement as well as patient satisfaction

in addition to high costs. Bilayered skin reconstruction using the human-derived glycerolized acellular dermis (Glyaderm®) has been reported to result in significantly improved scar quality using a two-step procedure. Unlike the necessary two-step procedure for most commercially available dermal substitutes

in this study we aimed to investigate the use of Glyaderm® in a more cost-effective single-stage engrafting. This is a method which

if autografts are available

is preferred by the majority of surgeons given the reduction in costs

hospitalization time and infection rate.MethodsA prospective

randomized

controlled

intra-individual

single-blinded study was performed

investigating the simultaneous application of Glyaderm® and STSG vs. STSG alone in full-thickness burns or comparable deep skin defects. During the acute phase

bacterial load

graft take and time to wound closure were assessed and were the primary outcomes. Aesthetic and functional results (secondary outcomes) were evaluated at 3

9 and 12 months follow-up using subjective and objective scar measurement tools. Biopsies for histological analysis were taken at 3 and 12 months.ResultsA total of 66 patients representing 82 wound comparisons were included. Graft take (>95%)

pain management and healing time were comparable in both groups. At 1 year follow-up

the overall Patient and Observer Scar Assessment Scale assessed by the patient was significantly in favour of sites where Glyaderm® was used. Not infrequently

patients attributed this difference to improved skin sensation. Histological analysis showed the presence of a well-formed neodermis

with donor elastin present for up to 12 months.ConclusionsA single-stage bilayered reconstruction with Glyaderm® and STSG results in optimal graft take without loss of Glyaderm® nor the overlaying autografts due to infection. The presence of elastin in the neodermis was demonstrated during long-term follow-up in all but one patient

which is a crucial factor contributing to the significantly improved overall scar quality as evaluated by the blinded patients.Trial registrationThe trial was registered on clinicaltrials.gov and received the following registration code: NCT01033604.

关键词

Keywords

BurnScarskinGlyaderm®Dermal substituteDermal regeneration templateElastin

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