Skin models of cutaneous toxicity, transdermal transport and wound repair

Inês Vilela de Sousa; Miguel J S Ferreira; Luís B Bebiano; Sandra Simões; Ana Filipa Matos; Rúben F Pereira; Pedro L Granja

doi:10.1093/burnst/tkad014

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Skin models of cutaneous toxicity, transdermal transport and wound repair

更新时间：2023-08-29

- Skin models of cutaneous toxicity, transdermal transport and wound repair
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
  
  1. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
  2. INEB - Instituto de Engenharia Biomédica, Universidade do Porto
  3. ICBAS – Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto
  4. FEUP – Faculdade de Engenharia da Universidade do Porto
  5. Department of Mechanical, Aerospace and Civil Engineering, School of Engineering, Faculty of Science and Engineering & Henry Royce Institute, Engineering Building A, The University of Manchester
  6. ISEP - Instituto Superior de Engenharia do Porto, Universidade do Porto
  7. iMed.ULisboa
  8. Universidade de Lisboa
  9. Faculty of Pharmacy, Universidade de Lisboa
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkad014
  CLC：
- Published：2023，
  
  Published Online：28 July 2023，
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Inês Vilela de Sousa, Miguel J S Ferreira, Luís B Bebiano, Sandra Simões, Ana Filipa Matos, Rúben F Pereira, Pedro L Granja, Skin models of cutaneous toxicity, transdermal transport and wound repair, Burns & Trauma, Volume 11, 2023, tkad014, https://doi.org/10.1093/burnst/tkad014
DOI：

Inês Vilela de Sousa, Miguel J S Ferreira, Luís B Bebiano, Sandra Simões, Ana Filipa Matos, Rúben F Pereira, Pedro L Granja, Skin models of cutaneous toxicity, transdermal transport and wound repair, Burns & Trauma, Volume 11, 2023, tkad014, https://doi.org/10.1093/burnst/tkad014 DOI：

摘要

Abstract

Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive molecules. However

the barrier properties of the skin

along with its multilayer structure

impose severe restrictions on drug transport and bioavailability. Thus

bioengineered models aimed at emulating the skin have been developed not only for optimizing the transdermal transport of different drugs and testing the safety and toxicity of substances but also for understanding the biological processes behind skin wounds. Even though in vivo research is often preferred to study biological processes involving the skin

in vitro and ex vivo strategies have been gaining increasing relevance in recent years. Indeed

there is a noticeably increasing adoption of in vitro and ex vivo methods by internationally accepted guidelines. Furthermore

microfluidic organ-on-a-chip devices are nowadays emerging as valuable tools for functional and behavioural skin emulation. Challenges in miniaturization

automation and reliability still need to be addressed in order to create skin models that can predict skin behaviour in a robust

high-throughput manner

while being compliant with regulatory issues

standards and guidelines. In this review

skin models for transdermal transport

wound repair and cutaneous toxicity will be discussed with a focus on high-throughput strategies. Novel microfluidic strategies driven by advancements in microfabrication technologies will also be revised as a way to improve the efficiency of existing models

both in terms of complexity and throughput.

关键词

Keywords

skinIn vitro modelsEx vivo modelsTransdermal transport assaysWound healing assaysToxicity assaysMicrofluidic chipSkin-on-a-chip

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