Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis

Yunquan Gong; Song Li; Jinghui Wu; Tongyi Zhang; Shunzheng Fang; Daibo Feng; Xiaoqing Luo; Jing Yuan; Yaran Wu; Xiaojing Yan; Yan Zhang; Jun Zhu; Jiangyi Wu; Jiqin Lian; Wei Xiang; Zhenhong Ni

doi:10.1093/burnst/tkac060

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Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis

更新时间：2023-05-16

- Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
  
  1. State Key Laboratory of Trauma
  2. Daping Hospital, Army Medical University
  3. Department of Orthopedics, Shanghai Hospital
  4. Department of Wound Repair and Rehabilitation Medicine
  5. Joint Surgery and Sport Medicine Department, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University
  6. Department of General practice, Chinese PLA General Hospital of the Central Theater Command
  7. Department of Biochemistry and Molecular Biology
  8. Army Medical University
  9. Department of Clinical Biochemistry
  10. Department of Pediatrics, People's Hospital Affiliated to Chongqing Three Gorges Medical College
  11. Department of Cardiology, Shanghai Hospital
  12. Department of Sports Medicine and Rehabilitation, Shenzhen Hospital, Peking University
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkac060
  CLC：
- Published：2023，
  
  Published Online：31 January 2023，
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Yunquan Gong, Song Li, Jinghui Wu, Tongyi Zhang, Shunzheng Fang, Daibo Feng, Xiaoqing Luo, Jing Yuan, Yaran Wu, Xiaojing Yan, Yan Zhang, Jun Zhu, Jiangyi Wu, Jiqin Lian, Wei Xiang, Zhenhong Ni, Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis, Burns & Trauma, Volume 11, 2023, tkac060, https://doi.org/10.1093/burnst/tkac060
DOI：

Yunquan Gong, Song Li, Jinghui Wu, Tongyi Zhang, Shunzheng Fang, Daibo Feng, Xiaoqing Luo, Jing Yuan, Yaran Wu, Xiaojing Yan, Yan Zhang, Jun Zhu, Jiangyi Wu, Jiqin Lian, Wei Xiang, Zhenhong Ni, Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis, Burns & Trauma, Volume 11, 2023, tkac060, https://doi.org/10.1093/burnst/tkac060 DOI：

摘要

Abstract

Autophagy

as a fundamental mechanism for cellular homeostasis

is generally involved in the occurrence and progression of various diseases. Osteoarthritis (OA) is the most common musculoskeletal disease that often leads to pain

disability and economic loss in patients. Post-traumatic OA (PTOA) is a subtype of OA

accounting for >12% of the overall burden of OA. PTOA is often caused by joint injuries including anterior cruciate ligament rupture

meniscus tear and intra-articular fracture. Although a variety of methods have been developed to treat acute joint injury

the current measures have limited success in effectively reducing the incidence and delaying the progression of PTOA. Therefore

the pathogenesis and intervention strategy of PTOA need further study. In the past decade

the roles and mechanisms of autophagy in PTOA have aroused great interest in the field. It was revealed that autophagy could maintain the homeostasis of chondrocytes

reduce joint inflammatory level

prevent chondrocyte death and matrix degradation

which accordingly improved joint symptoms and delayed the progression of PTOA. Moreover

many strategies that target PTOA have been revealed to promote autophagy. In this review

we summarize the roles and mechanisms of autophagy in PTOA and the current strategies for PTOA treatment that depend on autophagy regulation

which may be beneficial for PTOA patients in the future.

关键词

Keywords

AutophagyPost-traumatic osteoarthritismTORNoncoding RNAs

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