Autophagy in acute kidney injury and maladaptive kidney repair
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
1. Department of Nephrology
2. The Second Xiangya Hospital at Central South University
3. Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkac059
CLC：Published：2023，
Published Online：22 January 2023，
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Yu Xiang, Ying Fu, Wenwen Wu, Chengyuan Tang, Zheng Dong, Autophagy in acute kidney injury and maladaptive kidney repair, Burns & Trauma, Volume 11, 2023, tkac059, https://doi.org/10.1093/burnst/tkac059
摘要
Abstract
Acute kidney injury (AKI) is a major renal disease characterized by a sudden decrease in kidney function. After AKI
the kidney has the ability to repair
but if the initial injury is severe the repair may be incomplete or maladaptive and result in chronic kidney problems. Autophagy is a highly conserved pathway to deliver intracellular contents to lysosomes for degradation. Autophagy plays an important role in maintaining renal function and is involved in the pathogenesis of renal diseases. Autophagy is activated in various forms of AKI and acts as a defense mechanism against kidney cell injury and death. After AKI
autophagy is maintained at a relatively high level in kidney tubule cells during maladaptive kidney repair but the role of autophagy in maladaptive kidney repair has been controversial. Nonetheless
recent studies have demonstrated that autophagy may contribute to maladaptive kidney repair after AKI by inducing tubular degeneration and promoting a profibrotic phenotype in renal tubule cells. In this review
we analyze the role and regulation of autophagy in kidney injury and repair and discuss the therapeutic strategies by targeting autophagy.
关键词
Keywords
AutophagyAcute kidney injuryMaladaptive repairFibrosisChronic kidney disease
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