Polymeric biomaterials-based tissue engineering for wound healing: a systemic review
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
1. School of Bioscience and Engineering, Jadavpur University
2. Sustainability Cluster, University of Petroleum and Energy Studies
3. Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkac058
CLC：Published：2023，
Published Online：7 February 2023，
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Pratik Das, Suvendu Manna, Shivam Roy, Samit K Nandi, Piyali Basak, Polymeric biomaterials-based tissue engineering for wound healing: a systemic review, Burns & Trauma, Volume 11, 2023, tkac058, https://doi.org/10.1093/burnst/tkac058
摘要
Abstract
BackgroundBiomaterials are vital products used in clinical sectors as alternatives to several biological macromolecules for tissue engineering techniques owing to their numerous beneficial properties
including wound healing. The healing pattern generally depends upon the type of wounds
and restoration of the skin on damaged areas is greatly dependent on the depth and severity of the injury. The rate of wound healing relies on the type of biomaterials being incorporated for the fabrication of skin substitutes and their stability in in vivo conditions. In this review
a systematic literature search was performed on several databases to identify the most frequently used biomaterials for the development of successful wound healing agents against skin damage
along with their mechanisms of action.MethodThe relevant research articles of the last 5 years were identified
analysed and reviewed in this paper. The meta-analysis was carried out using PRISMA and the search was conducted in major scientific databases. The research of the most recent 5 years
from 2017–2021 was taken into consideration. The collected research papers were inspected thoroughly for further analysis. Recent advances in the utilization of natural and synthetic biomaterials (alone/in combination) to speed up the regeneration rate of injured cells in skin wounds were summarised. Finally
23 papers were critically reviewed and discussed.ResultsIn total
2022 scholarly articles were retrieved from databases utilizing the aforementioned input methods. After eliminating duplicates and articles published before 2017
~520 articles remained that were relevant to the topic at hand (biomaterials for wound healing) and could be evaluated for quality. Following different procedures
23 publications were selected as best fitting for data extraction. Preferred Reporting Items for Systematic Reviews and Meta-Analyses for this review illustrates the selection criteria
such as exclusion and inclusion parameters. The 23 recent publications pointed to the use of both natural and synthetic polymers in wound healing applications. Information related to wound type and the mechanism of action has also been reviewed carefully. The selected publication showed that composites of natural and synthetic polymers were used extensively for both surgical and burn wounds. Extensive research revealed the effects of polymer-based biomaterials in wound healing and their recent advancement.ConclusionsThe effects of biomaterials in wound healing are critically examined in this review. Different biomaterials have been tried to speed up the healing process
however
their success varies with the severity of the wound. However
some of the biomaterials raise questions when applied on a wide scale because of their scarcity
high transportation costs and processing challenges. Therefore
even if a biomaterial has good wound healing qualities
it may be technically unsuitable for use in actual medical scenarios. All of these restrictions have been examined closely in this review.
关键词
Keywords
Wound healingBiomaterialsTissue engineeringSkin regenerationPolymers
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