Epigenetic regulation of macrophage polarization in wound healing
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
1. State Key Laboratory of Trauma
2. Southwest Hospital, Third Military Medical University (Army Medical University)
3. Chongqing Key Laboratory for Disease Proteomics
4. No. Hospital of Joint Logistic Support Force of PLA,906
5. Academy of Biological Engineering
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkac057
CLC：Published：2023，
Published Online：17 January 2023，
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Cheng Chen, Tengfei Liu, Yuanyang Tang, Gaoxing Luo, Guangping Liang, Weifeng He, Epigenetic regulation of macrophage polarization in wound healing, Burns & Trauma, Volume 11, 2023, tkac057, https://doi.org/10.1093/burnst/tkac057
摘要
Abstract
The immune microenvironment plays a critical role in regulating skin wound healing. Macrophages
the main component of infiltrating inflammatory cells
play a pivotal role in shaping the immune microenvironment in the process of skin wound healing. Macrophages comprise the classic proinflammatory M1 subtype and anti-inflammatory M2 population. In the early inflammatory phase of skin wound closure
M1-like macrophages initiate and amplify the local inflammatory response to disinfect the injured tissue. In the late tissue-repairing phase
M2 macrophages are predominant in wound tissue and limit local inflammation to promote tissue repair. The biological function of macrophages is tightly linked with epigenomic organization. Transcription factors are essential for macrophage polarization. Epigenetic modification of transcription factors determines the heterogeneity of macrophages. In contrast
transcription factors also regulate the expression of epigenetic enzymes. Both transcription factors and epigenetic enzymes form a complex network that regulates the plasticity of macrophages. Here
we describe the latest knowledge concerning the potential epigenetic mechanisms that precisely regulate the biological function of macrophages and their effects on skin wound healing.
关键词
Keywords
EpigeneticsMacrophage polarizationWound healingImmune microenvironmentSignaling pathways
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