Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing

Zhengzhe Han; Lili Deng; Shiyan Chen; Huaping Wang; Yinjun Huang

doi:10.1093/burnst/tkac048

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Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing

更新时间：2023-05-16

- Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing
- Burns & Trauma Vol. 11, Issue 1, (2023)
- 作者机构：
  
  1. and Shanghai Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital
  2. Donghua University
  3. Shanghai Jiao Tong University School of Medicine
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkac048
  CLC：
- Published：2023，
  
  Published Online：3 February 2023，
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Zhengzhe Han, Lili Deng, Shiyan Chen, Huaping Wang, Yinjun Huang, Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing, Burns & Trauma, Volume 11, 2023, tkac048, https://doi.org/10.1093/burnst/tkac048
DOI：

Zhengzhe Han, Lili Deng, Shiyan Chen, Huaping Wang, Yinjun Huang, Zn2+-Loaded adhesive bacterial cellulose hydrogel with angiogenic and antibacterial abilities for accelerating wound healing, Burns & Trauma, Volume 11, 2023, tkac048, https://doi.org/10.1093/burnst/tkac048 DOI：

摘要

Abstract

BackgroundWound healing is a process that requires angiogenesis and antibacterial activities and it remains a challenge for both experimental and clinical research worldwide. Zn2+ has been reported to be widely involved in angiogenesis and exerts antibacterial effects

making it suitable as a treatment to promote wound healing. Therefore Zn2+-loaded adhesive bacterial cellulose hydrogel was designed to observe its angiogenic and antibacterial abilities in the wound healing process.MethodsThe characterization

tensile strength

swelling behaviors and antibacterial activity of bacterial cellulose/polydopamine/zeolitic imidazolate framework-8 (BC/PDA/ZIF8) hydrogels were tested. Cell-Counting-Kit-8 (CCK8)

transwell

tube formation and real time qunantitative PCR (qRT-PCR) assays were performed to evaluate the cell compatibility of BC/PDA/ZIF8 hydrogels in vitro. A full-thickness defect wound model and histological assays were used to evaluate the BC/PDA/ZIF8 hydrogels in vivo.ResultsThe prepared BC/PDA/ZIF8 hydrogels exhibited suitable mechanical strength

excellent swelling properties

good tissue adhesion

efficient angiogenic and antibacterial effects and good performance as a physical barrier. In vivo experiments showed that the BC/PDA/ZIF8 hydrogels accelerated wound healing in a full-thickness defect wound model by stimulating angiogenesis.ConclusionsThis study proved that BC/PDA/ZIF8 hydrogels possess great potential for promoting satisfactory wound healing in full-thickness wound defects through antibacterial effects and improved cell proliferation

tissue formation

remodeling and re-epithelialization.

关键词

Keywords

HydrogelMechanical propertiesBiocompatibilityAngiogenic effectsWound healing

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