Skin cell-derived extracellular vesicles: a promising therapeutic strategy for cutaneous injury
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
1. Jiangsu University
2. The Affiliated Yixing Hospital of Jiangsu University
3. Aoyang Institute of Cancer
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkac037
CLC：Published：2022，
Published Online：18 October 2022，
扫 描 看 全 文
Min Wang, Peipei Wu, Jin Huang, Wenhui Liu, Hui Qian, Yaoxiang Sun, Hui Shi, Skin cell-derived extracellular vesicles: a promising therapeutic strategy for cutaneous injury, Burns & Trauma, Volume 10, 2022, tkac037, https://doi.org/10.1093/burnst/tkac037
摘要
Abstract
Wound healing refers to the healing process that occurs after the skin and other tissues are separated or damaged by internal or external forces. It is a complex combination of tissue regeneration
granulation tissue hyperplasia
and scar formation
and shows the synergistic effects of these processes. After skin damage
the environment around the wound and the cells at site of the damage respond immediately
and a range of cytokines and growth factors are released. In cutaneous injury
extracellular vesicle (EV) signaling plays a vital role in the healing process via paracrine and endocrine mechanisms. EVs are natural intercellular and inter-organ communication tools that carry various bioactive substances for message exchange. Stem cells and stem cell EVs facilitate tissue repair
showing promising potential in regenerative medicine. Nevertheless
EVs derived from specific skin tissue cells
such as epidermal cells
fibroblasts
vascular endothelial cells and inflammatory cells
also play important roles in cutaneous tissue repair. Here
we describe the characteristics of wound healing
concentrating on the production and functions of EVs derived from specific skin cells
and provide new ideas for wound therapy using EVs.
关键词
Keywords
Extracellular vesiclesSpecific skin tissue cellCutaneous injuryWound healing
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