Skin biomechanics: a potential therapeutic intervention target to reduce scarring
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
1. Centre for Biomedical Technologies
2. Queensland University of Technology
3. Herston Biofabrication Institute, Metro North Hospital and Health Service
4. Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service
5. The University of Queensland Diamantina Institute, Translational Research Institute, The University of Queensland
6. Centre for Dermatology Research
7. University of Manchester
8. MRC-SA Wound Healing Unit
9. University of Cape Town
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkac036
CLC：Published：2022，
Published Online：23 August 2022，
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Motaharesadat Hosseini, Jason Brown, Kiarash Khosrotehrani, Ardeshir Bayat, Abbas Shafiee, Skin biomechanics: a potential therapeutic intervention target to reduce scarring, Burns & Trauma, Volume 10, 2022, tkac036, https://doi.org/10.1093/burnst/tkac036
摘要
Abstract
Pathological scarring imposes a major clinical and social burden worldwide. Human cutaneous wounds are responsive to mechanical forces and convert mechanical cues to biochemical signals that eventually promote scarring. To understand the mechanotransduction pathways in cutaneous scarring and develop new mechanotherapy approaches to achieve optimal scarring
the current study highlights the mechanical behavior of unwounded and scarred skin as well as intra- and extracellular mechanisms behind keloid and hypertrophic scars. Additionally
the therapeutic interventions that promote optimal scar healing by mechanical means at the molecular
cellular or tissue level are extensively reviewed. The current literature highlights the significant role of fibroblasts in wound contraction and scar formation via differentiation into myofibroblasts. Thus
understanding myofibroblasts and their responses to mechanical loading allows the development of new scar therapeutics. A review of the current clinical and preclinical studies suggests that existing treatment strategies only reduce scarring on a small scale after wound closure and result in poor functional and aesthetic outcomes. Therefore
the perspective of mechanotherapies needs to consider the application of both mechanical forces and biochemical cues to achieve optimal scarring. Moreover
early intervention is critical in wound management; thus
mechanoregulation should be conducted during the healing process to avoid scar maturation. Future studies should either consider combining mechanical loading (pressure) therapies with tension offloading approaches for scar management or developing more effective early therapies based on contraction-blocking biomaterials for the prevention of pathological scarring.
关键词
Keywords
Dermal fibrosisMechanotransductionPressure therapyTension therapyWound healingSkin biomechanics
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