Strategies for improving adipose-derived stem cells for tissue regeneration
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
2. Department of Plastic and Burn Surgery, West China Hospital, Sichuan University
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkac028
CLC：Published：2022，
Published Online：16 August 2022，
扫 描 看 全 文
Xin Yuan, Li Li, Haofan Liu, Jing Luo, Yongchao Zhao, Cheng Pan, Xue Zhang, Yuwen Chen, Maling Gou, Strategies for improving adipose-derived stem cells for tissue regeneration, Burns & Trauma, Volume 10, 2022, tkac028, https://doi.org/10.1093/burnst/tkac028
摘要
Abstract
Adipose-derived stem cells (ADSCs) have promising applications in tissue regeneration. Currently
there are only a few ADSC products that have been approved for clinical use. The clinical application of ADSCs still faces many challenges. Here
we review emerging strategies to improve the therapeutic efficacy of ADSCs in tissue regeneration. First
a great quantity of cells is often needed for the stem cell therapies
which requires the advanced cell expansion technologies. In addition cell-derived products are also required for the development of ‘cell-free’ therapies to overcome the drawbacks of cell-based therapies. Second
it is necessary to strengthen the regenerative functions of ADSCs
including viability
differentiation and paracrine ability
for the tissue repair and regeneration required for different physiological and pathophysiological conditions. Third
poor delivery efficiency also restricts the therapeutic effect of ADSCs. Effective methods to improve cell delivery include alleviating harsh microenvironments
enhancing targeting ability and prolonging cell retention. Moreover
we also point out some critical issues about the sources
effectiveness and safety of ADSCs. With these advanced strategies to improve the therapeutic efficacy of ADSCs
ADSC-based treatment holds great promise for clinical applications in tissue regeneration.
关键词
Keywords
Adipose-derived stem cellsTissue regenerationStem cell therapy
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