Advances in the pathogenesis and clinical application prospects of tumor biomolecules in keloid

Yijun Xia; Youbin Wang; Mengjie Shan; Yan Hao; Hao Liu; Qiao Chen; Zhengyun Liang

doi:10.1093/burnst/tkac025

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Advances in the pathogenesis and clinical application prospects of tumor biomolecules in keloid

更新时间：2023-09-05

- Advances in the pathogenesis and clinical application prospects of tumor biomolecules in keloid
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
  
  1. Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College
  2. Department of Plastic Surgery, Peking Union Medical College Hospital
- 作者简介：
- 基金信息：
- DOI：10.1093/burnst/tkac025
  CLC：
- Published：2022，
  
  Published Online：25 June 2022，
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Yijun Xia, Youbin Wang, Mengjie Shan, Yan Hao, Hao Liu, Qiao Chen, Zhengyun Liang, Advances in the pathogenesis and clinical application prospects of tumor biomolecules in keloid, Burns & Trauma, Volume 10, 2022, tkac025, https://doi.org/10.1093/burnst/tkac025
DOI：

Yijun Xia, Youbin Wang, Mengjie Shan, Yan Hao, Hao Liu, Qiao Chen, Zhengyun Liang, Advances in the pathogenesis and clinical application prospects of tumor biomolecules in keloid, Burns & Trauma, Volume 10, 2022, tkac025, https://doi.org/10.1093/burnst/tkac025 DOI：

摘要

Abstract

Keloid scarring is a kind of pathological healing manifestation after skin injury and possesses various tumor properties

such as the Warburg effect

epithelial–mesenchymal transition (EMT)

expression imbalances of apoptosis-related genes and the presence of stem cells. Abnormal expression of tumor signatures is critical to the initiation and operation of these effects. Although previous experimental studies have recognized the potential value of a single or several tumor biomolecules in keloids

a comprehensive evaluation system for multiple tumor signatures in keloid scarring is still lacking. This paper aims to summarize tumor biomolecules in keloids from the perspectives of liquid biopsy

genetics

proteomics and epigenetics and to investigate their mechanisms of action and feasibility from bench to bedside. Liquid biopsy is suitable for the early screening of people with keloids due to its noninvasive and accurate performance. Epigenetic biomarkers do not require changes in the gene sequence and their reversibility and tissue specificity make them ideal therapeutic targets. Nonetheless

given the ethnic specificity and genetic predisposition of keloids

more large-sample multicenter studies are indispensable for determining the prevalence of these signatures and for establishing diagnostic criteria and therapeutic efficacy estimations based on these molecules.

关键词

Keywords

Tumor signaturesKeloidProteomeEpigeneticsExosomesTumor biomoleculesBiomarkers

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