Commercial wound dressings for the treatment of exuding wounds: an in-depth physico-chemical comparative study
- Burns & Trauma Vol. 10, Issue 1, (2022)
- 作者机构：
1. Polymer Chemistry & Biomaterials Research Group, Centre of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University
2. Smart Polymeric Biomaterials Research Group, Biomaterials and Tissue Engineering (SIEM) @ Campus Group T Leuven
- 作者简介：
- 基金信息：
DOI：10.1093/burnst/tkac024
CLC：Published：2022，
Published Online：21 June 2022，
扫 描 看 全 文
Manon Minsart, Sandra Van Vlierberghe, Peter Dubruel, Arn Mignon, Commercial wound dressings for the treatment of exuding wounds: an in-depth physico-chemical comparative study, Burns & Trauma, Volume 10, 2022, tkac024, https://doi.org/10.1093/burnst/tkac024
摘要
Abstract
BackgroundNowadays
a wide range of wound dressings is already commercially available. The selection of the dressing is of paramount importance as inappropriate wound management and dressing selection can delay the wound healing process. Not only can this be distressing for the patient
but it can also contribute to complications such as maceration and subsequent infection. Many researchers are targeting the design of dressings with superior properties over existing commercial dressings. However
reported results in the state-of-the-art are rarely benchmarked against commercial dressings. The aim of this study was to determine several characteristics of a large variety of the most frequently used commercial wound dressings
providing an overview for both practitioners and researchers.MethodsFor this comparative study
11 frequently used commercial wound dressings were selected
representing the different types. The morphology was studied using scanning electron microscopy. The dressings were characterized in terms of swelling capacity (water
phosphate buffered saline and simulated wound fluid)
moisture vapour transmission rate (MVTR) and moisture uptake capacity (via dynamic vapour sorption) as well as mechanical properties using tensile testing and texturometry.ResultsThe selected dressings showed distinctive morphological differences (fibrous
porous and/or gel) which was reflected in the different properties. Indeed
the swelling capacities ranged between 1.5 and 23.2 g/g (water)
2.1 and 17.6 g/g (phosphate buffered saline) or 2.9 and 20.8 g/g (simulated wound fluid). The swelling capacity of the dressings in water increased even further upon freeze-drying
due to the formation of pores. The MVTR values varied between 40 and 930 g/m2/24 h. The maximal moisture uptake capacity varied between 5.8% and 105.7% at 95% relative humidity. Some commercial dressings exhibited a superior mechanical strength
due to either being hydrophobic or multi-layered.ConclusionsThe present work not only offers insight into a valuable toolbox of suitable wound dressing characterization techniques
but also provides an extensive landscaping of commercial dressings along with their physico-chemical properties
obtained through reproducible experimental protocols. Furthermore
it ensures appropriate benchmark values for commercial dressings in all forthcoming studies and could aid researchers with the development of novel modern wound dressings. The tested dressings either exhibited a high strength or a high swelling capacity
suggesting that there is still a strong potential in the wound dressings market for dressings that possess both.
关键词
Keywords
Wound dressingsBurnsExuding woundsWound healingExudate managementPhysico-chemical
references
1.Boateng J, Catanzano O. Advanced therapeutic dressings for effective wound healing - a review. J Pharm Sci. 2015;104:3653–80.
2.Sen CK. Human wounds and its burden: an updated compendium of estimates. Adv Wound Care. 2019;8:39–48.
3.Ye H, De S. Thermal injury of skin and subcutaneous tissues: a review of experimental approaches and numerical models. Burns. 2017;43:909–32.
4.Kolarsick PAJ, Kolarsick MA, Goodwin C. Anatomy and physiology of the skin. J Dermatol Nurses Assoc. 2011;3:203–13.
5.Mescher AL. Junqueira’s Basic Histology Text and Atlas: Fourteenth edition. Weitz M, Kearns B (eds).USA: McGraw Hill Education, 2016.
6.Dhivya S, Padma VV, Santhini E. Wound dressings - a review. Biomed. 2015;5:24–8.
7.Rieger KA, Birch NP, Schiffman JD. Designing electrospun nanofiber Mats to promote wound healing- a review. J Mater Chem B. 2013;1:4531–41.
8.Powers JG, Higham C, Broussard K, Phillips TJ. Wound healing and treating wounds: chronic wound care and management. J Am Acad Dermatol. 2016;74:607–25.
9.Varaprasad K, Jayaramudu T, Kanikireddy V, Toro C, Sadiku ER. Alginate-based composite materials for wound dressing application: a mini review. Carbohydr Polym. 2020;236:116025. https://doi.org/10.1016/j.carbpol.2020.116025.
10.Mir M, Ali MN, Barakullah A, Gulzar A, Arshad M, Fatima S, et al. Synthetic polymeric biomaterials for wound healing: a review. Prog Biomater. 2018;7:1–21.
11.Mele E. Electrospinning of natural polymers for advanced wound care: towards responsive and adaptive dressings. J Mater Chem B. 2016;4:4801–12.
12.Jones V, Grey JE, Harding KG. ABC of wound healing: wound dressings. Br Med J. 2006;332:777–80.
13.Deǧim Z. Use of microparticulate systems to accelerate skin wound healing. J Drug Target. 2008;16:437–48.
14.Uzun M, Anand SC, Shah T. In vitro characterisation and evaluation of different types of wound dressing materials. J Biomed Eng Technol. 2013;1:1–7.
15.Vowden K, Vowden P. Wound dressings: principles and practice. Surg. 2014;32:462–7.
16.Boateng JS, Matthews KH, Stevens HNE, Eccleston GM. Wound healing dressings and drug delivery systems: a review. J Pharm Sci. 2008;97:2892–923.
17.Falanga V, Brem H, Ennis WJ, Wolcott R, Gould LJ, Ayello EA. Maintenance debridement in the treatment of difficult-to-heal chronic wounds. Recommendations of an expert panel. Ostomy Wound Manage. 2008;Suppl:2–13.
18.Agarwal A, McAnulty JF, Schurr MJ, Murphy CJ, Abbott NL. Advanced Wound Repair Therapies. Farrar D (ed.).Woodhead Publishing Limited, Elsevier Inc, 2011, Ch 8.
19.Verbelen J, Hoeksema H, Heyneman A, Pirayesh A, Monstrey S. Aquacel® ag dressing versus Acticoat® dressing in partial thickness burns: a prospective, randomized, controlled study in 100 patients. Part 1: burn wound healing. Burns. 2014;40:416–27.
20.Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: a review of patents and commercial products. Eur Polym J. 2015;65:252–67.
21.Mogoşanu GD, Grumezescu AM. Natural and synthetic polymers for wounds and burns dressing. Int J Pharm. 2014;463:127–36.
22.Higgins L, Wasiak J, Spinks A, Cleland H. Split-thickness skin graft donor site management: a randomized controlled trial comparing polyurethane with calcium alginate dressings. Int Wound J. 2012;9:126–31.
23.Leaper DJ, Schultz G, Carville K, Fletcher J, Swanson T, Drake R. Extending the TIME concept: what have we learned in the past 10 years? Int Wound J. 2012;9:1–19.
24.Dong R, Guo B. Smart wound dressings for wound healing. Nano Today. 2021;41:101290. https://doi.org/10.1016/j.nantod.2021.101290.
25.Simoska O, Duay J, Stevenson KJ. Electrochemical detection of Multianalyte biomarkers in wound healing efficacy. ACS Sensors. 2020;5:3547–57.
26.Mostafalu P, Tamayol A, Rahimi R, Ochoa M, Khalilpour A, Kiaee G, et al. Smart bandage for monitoring and treatment of chronic wounds. Small. 2018;14:1–9.
27.Mariani F, Serafini M, Gualandi I, Arcangeli D, Decataldo F, Possanzini L, et al. Advanced wound dressing for real-time pH monitoring. ACS Sensors. 2021;6:2366–77.
28.Tessarolo M, Possanzini L, Gualandi I, Mariani F, Torchia LD, Arcangeli D, et al. Wireless textile moisture sensor for wound care. Front Phys. 2021;9:1–9.
29.C. Inc. ConvaTec. https://www.convatec.com/wound-skin, accessed: January, 2021.
30.M.H.C. AB. Mölnlycke. https://www.molnlycke.com/products-solutions, accessed: January, 2021.
31.Paul Hartmann. Hartmann. https://www.hartmann.info/en-au/products/wound-management, accessed: January, 2021.
32.Smith & Nephew. https://www.smith-nephew.com/professional/products/advanced-wound-management/, accessed: January, 2021.
33.Akhmetova A, Saliev T, Allan IU, Illsley MJ, Nurgozhin T, Mikhalovsky S. Comprehensive review of topical odor-controlling treatment options for chronic wounds. J Wound, Ostomy Cont Nurs. 2016;43:598–609.
34.Illsley MJ, Akhmetova A, Bowyer C, Nurgozhin T, Mikhalovsky SV, Farrer J, et al. Activated carbon-plasticised agarose composite films for the adsorption of thiol as a model of wound malodour. J Mater Sci Mater Med. 2017;28:(10)154. https://doi.org/10.1007/s10856-017-5964-x.
35.Bradshaw CE. An in vitro comparison of the antimicrobial activity of honey, iodine and silver wound dressings. Biosci Horizons. 2011;4:61–70.
36.Parikh DV, Fink T, Delucca AJ, Parikh AD. Absorption and swelling characteristics of silver (I) antimicrobial wound dressings. Text Res J. 2011;81:494–503.
37.Minsart M, Mignon A, Arslan A, Allan IU, Van Vlierberghe S, Dubruel P. Activated carbon containing PEG-based hydrogels as novel candidate dressings for the treatment of malodorous wounds. Macromol Mater Eng. 2021;306:1–12.
38.Grenier J, Duval H, Barou F, Lv P, David B, Letourneur D. Mechanisms of pore formation in hydrogel scaffolds textured by freeze-drying. Acta Biomater. 2019;94:195–203.
39.Johnson BD, Beebe DJ, Crone WC. Effects of swelling on the mechanical properties of a pH-sensitive hydrogel for use in microfluidic devices. Mater Sci Eng C. 2004;24:575–81.
40.Chen H, Xing X, Tan H, Jia Y, Zhou T, Chen Y, et al. Covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing. Mater Sci Eng C. 2017;70:287–95.
41.Zahedi P, Rezaeian I, Ranaei-Siadat SO, Jafari SH, Supaphol P. A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polym Adv Technol. 2010;21:77–95.
42.Chiu CT, Lee JS, Chu CS, Chang YP, Wang YJ. Development of two alginate-based wound dressings. J Mater Sci Mater Med. 2008;19:2503–13.
43.Liu L, Li X, Nagao M, Elias AL, Narain R, Chung HJ. A pH-indicating colorimetric tough hydrogel patch towards applications in a substrate for smart wound dressings. Polymers (Basel). 2017;9(11):558. https://doi.org/10.3390/polym9110558.
44.Xu R, Xia H, He W, Li Z, Zhao J, Liu B, et al. Controlled water vapor transmission rate promotes wound-healing via wound re-epithelialization and contraction enhancement. Sci Rep. 2016;6:1–12.
45.Wlaschin KF, Ninkovic J, Griesgraber GW, Colak Atan S, Young AJ, Pereira JM, et al. The impact of first-aid dressing design on healing of porcine partial thickness wounds. Wound Repair Regen. 2019;27:622–33.
46.Urtasun N, Mignon A, Martínez-Alvarez LM, Baieli MF, Hirsch DB, Cascone O, et al. Synthesis and characterization of chitosan mini-spheres with immobilized dye as affinity ligand for the purification of lactoperoxidase and lactoferrin from dairy whey. Sep Purif Technol. 2021;255:117700. https://doi.org/10.1016/j.seppur.2020.117700.
0
Views
0
下载量
0
CSCD
- Meta-XMLDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
